| Edinger–Westphal nucleus |
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Section through superior colliculus (unlabeled) showing path of oculomotor nerve. ("Edinger–Westphal nucleus" is not on diagram, but would be near oculomotor nuclei.)
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Figure showing the different groups of cells, which constitute, according to Perlia, the nucleus of origin of the oculomotor nerve.
1. Posterior dorsal nucleus.
1’. Posterior ventral nucleus.
2. Anterior dorsal nucleus.
2’. Anterior ventral nucleus.
3. Central nucleus.
4. Nucleus of Edinger and Westphal.
5. Antero-internal nucleus.
6. Antero-external nucleus.
8. Crossed fibers.
9. Trochlear nerve, with 9’, its nucleus of origin, and 9", its decussation.
10. Third ventricle.
M, M. Median line. |
| Details |
| Latin |
nuclei accessorii nervi oculomotorii |
| Components |
Provides input to Parasympathetic root of ciliary ganglion |
| Identifiers |
| NeuroNames |
hier-489 |
| NeuroLex ID |
Parvocellular oculomotor nucleus |
Dorlands
/Elsevier |
n_11/12580082 |
| Anatomical terms of neuroanatomy |
The Edinger–Westphal nucleus (accessory oculomotor nucleus) are the parasympathetic pre-ganglionic neurons that originate the oculomotor nerve. It supplies the iris sphincter muscle and the ciliary muscle.
Alternatively, the Edinger–Westphal nucleus is a term often used to refer to the adjacent population of non-preganglionic neurons that do not project to the ciliary ganglion, but rather project to the spinal cord, dorsal raphe nucleus, and lateral septal nuclei.[1]
Unlike the classical preganglionic Edinger–Westphal neurons that contain choline acetyltransferase, neurons of the non-preganglionic Edinger–Westphal nucleus contain various neuropeptides, such as Urocortin and cocaine- and amphetamine-regulated transcript.[2]
Previously, it had been proposed to rename this group of non-preganglionic, neuropeptide-containing neurons to perioculomotor subgriseal neuronal stream, abbreviated pIIISG.[3]
However, more recently, a final nomenclature has been determined. Preganglionic oculomotor neurons within the Edinger–Westphal nucleus shall be referred to as the EWpg, and the neuropeptide-containing neurons shall be known as the centrally-projecting Edinger Westphal nucleus, or EWcp.[1]
Contents
- 1 Location
- 2 Function
- 3 Eponym
- 4 Additional images
- 5 References
- 6 External links
Location
The paired nuclei are posterior to the main motor nucleus (oculomotor nucleus) and anterolateral to the cerebral aqueduct in the rostral midbrain at the level of the superior colliculus.
It is the most rostral of the parasympathetic nuclei in the brain stem.
Function
The Edinger–Westphal nucleus supplies preganglionic parasympathetic fibers to the eye, constricting the pupil, accommodating the lens, and convergence of the eyes.[4]
It has also been implicated in the mirroring of pupil size in sad facial expressions. When seeing a sad face, participants' pupils dilated or constricted to mirror the face they saw, which predicted both how sad they perceived the face to be, as well as activity within this region.[5][6]
Eponym
The nucleus is named for both Ludwig Edinger, from Frankfurt, who demonstrated it in the fetus in 1885, and for Karl Friedrich Otto Westphal, from Berlin, who demonstrated it in the adult in 1887.[7]
Additional images
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The cranial nerve nuclei schematically represented; dorsal view. Motor nuclei in red; sensory in blue.
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Nuclei of origin of cranial motor nerves schematically represented; lateral view.
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Primary terminal nuclei of the afferent (sensory) cranial nerves schematically represented; lateral view.
References
- ^ a b Kozicz T, Bittencourt JC, May PJ, Reiner A, Gamlin PD, Palkovits M, Horn AK, Toledo CA, Ryabinin AE (2011). "The Edinger–Westphal nucleus: A historical, structural and functional perspective on a dichotomous terminology". J. Comp. Neurol. In press. 519 (8): 1413–34. doi:10.1002/cne.22580. PMID 21452224.
- ^ Kozicz, T. (2003). "Neurons colocalizing urocortin and cocaine and amphetamine-regulated transcript immunoreactivities are induced by acute lipopolysaccharide stress in the Edinger–Westphal nucleus in the rat". Neuroscience 116 (2): 315–20. doi:10.1016/S0306-4522(02)00772-8. PMID 12559087.
- ^ May PJ, Reiner AJ, Ryabinin AE (March 2008). "Comparison of the Distributions of Urocortin Containing and Cholinergic Neurons in the Perioculomotor Midbrain of the Cat and Macaque". J. Comp. Neurol. 507 (3): 1300–16. doi:10.1002/cne.21514. PMC 2863095. PMID 18186029.
- ^ Kaufman, Paul L.; Levin, Leonard A.; Alm, Albert (2011). Adler's Physiology of the Eye. Elsevier Health Sciences. p. 508. ISBN 0-323-05714-4.
- ^ Harrison, NA; Wilson, CE; Critchley, HD (2007). "Processing of observed pupil size modulates perception of sadness and predicts empathy". Emotion (Washington, D.C.) 7 (4): 724–9. doi:10.1037/1528-3542.7.4.724. PMID 18039039.
- ^ Harrison, NA; Singer, T; Rotshtein, P; Dolan, RJ; Critchley, HD (2006). "Pupillary contagion: central mechanisms engaged in sadness processing". Social cognitive and affective neuroscience 1 (1): 5–17. doi:10.1093/scan/nsl006. PMC 1716019. PMID 17186063.
- ^ synd/893 at Who Named It?
External links
- -248184792 at GPnotebook
- Diagram at Columbia
- Stained brain slice images which include the "Edinger–Westphal nucleus" at the BrainMaps project
- MedEd at Loyola Neuro/frames/nlBSs/nl18fr.htm
- Cranial Nerves at Yale 3-12
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Anatomy of the midbrain
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Tectum
(Dorsal) |
| Surface |
- Corpora quadrigemina:
- Inferior colliculus
- Superior colliculus
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| Grey matter |
|
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| White: Sensory/ascending |
- Spinotectal tract
- Central tegmental tract
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| White: Motor/descending |
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Peduncle
(Ventral) |
| Tegmentum |
| White: Sensory/ascending |
- Lemnisci
- Ascending MLF
- Vestibulo-oculomotor fibers
- Spinothalamic tract
- Anterior trigeminothalamic tract
- Dentatothalamic tract
|
|
| White: Motor/descending |
- Rubrospinal tract
- Rubro-olivary tract
- Descending MLF
|
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| Grey: cranial nuclei |
- GSA
- Mesencephalic- GSE
- Oculomotor nucleus, Trochlear nucleus- GVE
- Edinger–Westphal nucleus
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| Grey: other |
- Periaqueductal gray
- Raphe nuclei
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- Ventral tegmental area
- Pedunculopontine nucleus
- Red nucleus
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- Rostral interstitial nucleus of medial longitudinal fasciculus
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| Ventricular system |
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| Base |
| White: Motor/descending |
- Cerebral crus: Corticospinal tract
- Corticobulbar tract
- Corticopontine tract/Frontopontine fibers/Temporopontine fibers
|
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| Grey: Substantia nigra |
- Pars compacta
- Pars reticulata
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| Surface |
- Superior cerebellar peduncle
- Interpeduncular fossa
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Index of the central nervous system
|
|
| Description |
- Anatomy
- meninges
- cortex
- association fibers
- commissural fibers
- lateral ventricles
- basal ganglia
- diencephalon
- mesencephalon
- fourth ventricle
- pons
- cerebellum
- medulla
- spinal cord
- Physiology
- Development
|
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| Disease |
- Meningitis
- Demyelinating diseases
- Seizures and epilepsy
- Headache
- Stroke
- Sleep
- Congenital
- Injury
- Neoplasms and cancer
- Other
- Symptoms and signs
- head and neck
- eponymous
- lesions
|
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| Treatment |
- Procedures
- Drugs
- general anesthetics
- analgesics
- addiction
- epilepsy
- cholinergics
- migraine
- Parkinson's
- vertigo
- other
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The cranial nerves
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| terminal (SN->0) |
|
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| olfactory (AON->I) |
- olfactory bulb
- olfactory tract
|
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| optic (LGN->II) |
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oculomotor
(ON, EWN->III) |
- superior branch
- parasympathetic root of ciliary ganglion/ciliary ganglion
- inferior branch
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| trochlear (TN->IV) |
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trigeminal
(PSN, TSN, MN, TMN->V) |
- trigeminal ganglion
- ophthalmic
- maxillary
- mandibular
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| abducens (AN->VI) |
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| facial (FMN, SN, SSN->VII) |
| near origin |
- nervus intermedius
- geniculate
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inside
facial canal |
- greater petrosal
- nerve to the stapedius
- chorda tympani
- lingual nerve
- submandibular ganglion
|
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at stylomastoid
foramen |
- posterior auricular
- suprahyoid
- parotid plexus
- temporal
- zygomatic
- buccal
- mandibular
- cervical
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vestibulocochlear
(VN, CN->VIII) |
- cochlear
- striae medullares
- lateral lemniscus
- vestibular
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glossopharyngeal
(NA, ISN, SN->IX) |
| before jugular fossa |
|
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| after jugular fossa |
- tympanic
- tympanic plexus
- lesser petrosal
- otic ganglion
- stylopharyngeal branch
- pharyngeal branches
- tonsillar branches
- lingual branches
- carotid sinus
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vagus
(NA, DNVN, SN->X) |
| before jugular fossa |
|
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| after jugular fossa |
- meningeal branch
- auricular branch
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| neck |
- pharyngeal branch
- superior laryngeal
- recurrent laryngeal (inferior)
- superior cervical cardiac
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| thorax |
- inferior cardiac
- pulmonary
- vagal trunks
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| abdomen |
- celiac
- renal
- hepatic
- anterior gastric
- posterior gastric
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| accessory (NA, SAN->XI) |
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| hypoglossal (HN->XII) |
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Index of the peripheral nervous system
|
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| Description |
- Anatomy
- Nerves
- cranial
- trigeminal
- cervical
- brachial
- lumbosacral plexus
- somatosensory
- spinal
- autonomic
- Physiology
- reflexes
- proteins
- neurotransmitters
- transporters
- Development
|
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| Disease |
- Autonomic
- Congenital
- Injury
- Neoplasms and cancer
- Other
- Symptoms and signs
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| Treatment |
- Procedures
- Local anesthetics
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Sensory system: Visual system and eye movement pathways
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| Visual perception |
- 1° (Retina bipolar cell) → 2° (Ganglionic cell) → 3° (Optic nerve → Optic chiasm → Optic tract → LGN of Thalamus) → 4° (Optic radiation → Cuneus and Lingual gyrus of Visual cortex → Blobs → Globs)
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| Muscles of orbit |
| Tracking |
| Smooth pursuit: |
- Parietal lobe
- Occipital lobe
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| Saccade: |
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- Nystagmus → Fixation reflex → PPRF
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| Horizontal gaze |
- PPRF → Abducens nucleus → MLF → Oculomotor nucleus → Medial rectus muscle
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| Vertical gaze |
- Rostral interstitial nucleus → Oculomotor nucleus, Trochlear nucleus → Muscles of orbit
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| Vestibulo–ocular reflex |
- Semicircular canal → Vestibulocochlear nerve → Vestibular nuclei → Abducens nucleus → MLF (Vestibulo-oculomotor fibers) → Oculomotor nucleus → Medial rectus muscle
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| Pupillary reflex |
| Pupillary response |
- 1° (Posterior hypothalamus → Ciliospinal center) → 2° (Superior cervical ganglion) → 3° (Sympathetic root of ciliary ganglion → Nasociliary nerve → Long ciliary nerves → Iris dilator muscle)
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Pupillary light reflex
(constriction) |
- 1° (Retina → Optic nerve → Optic chiasm → Optic tract → Pretectal nucleus) → 2° (Edinger–Westphal nucleus) → 3° (Oculomotor nerve → Parasympathetic root of ciliary ganglion → Ciliary ganglion) → (4° Short ciliary nerves → Iris sphincter muscle)
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Accommodation
vergence |
- 1° (Retina → Optic nerve → Optic chiasm → Optic tract → Visual cortex → Brodmann area 19 → Pretectal area) → 2° (Edinger–Westphal nucleus) → 3° (Short ciliary nerves → Ciliary ganglion → Ciliary muscle)
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| Circadian rhythm |
- Retina → Retinohypothalamic tract → Hypothalamus (Suprachiasmatic nucleus)
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| Description |
- Anatomy
- bones
- muscles
- organs
- neural pathways
- Physiology
- Development
|
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| Disease |
- Congenital
- Corneal dystrophy
- Neoplasms and cancer
- Other
- Symptoms and signs
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| Treatment |
- Procedures
- Drugs
- infection
- glaucoma and miosis
- mydriatics
- vascular
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