WordNet

any of a large variety of proteins normally present in the body or produced in response to an antigen which it neutralizes, thus producing an immune response

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Humoral response to EBV is associated with cortical atrophy and lesion burden in patients with MS.

Zivadinov R1, Cerza N1, Hagemeier J1, Carl E1, Badgett D1, Ramasamy DP1, Weinstock-Guttman B1, Ramanathan M1.
Neurology® neuroimmunology & neuroinflammation.Neurol Neuroimmunol Neuroinflamm.2016 Jan 7;3(1):e190. doi: 10.1212/NXI.0000000000000190. eCollection 2016.
OBJECTIVE: Because dysregulated Epstein-Barr virus (EBV)-infected B cells may induce meningeal inflammation, which contributes to cortical pathology in multiple sclerosis (MS), we investigated associations between antibody responses to EBV and development of cortical pathology in MS.METHODS: We incl
PMID 26770996

Application of synthetic peptides for detection of anti-citrullinated peptide antibodies.

Trier NH1, Holm BE1, Slot O2, Locht H3, Lindegaard H4, Svendsen A5, Nielsen CT6, Jacobsen S6, Theander E7, Houen G8.
Peptides.Peptides.2016 Feb;76:87-95. doi: 10.1016/j.peptides.2016.01.005. Epub 2016 Jan 12.
Anti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis (RA) and represent an important tool for the serological diagnosis of RA. In this study, we describe ACPA reactivity to overlapping citrullinated Epstein-Barr virus nuclear antigen-1 (EBNA-1)-derived peptides and an
PMID 26796582

Genetic loci for Epstein-Barr virus nuclear antigen-1 are associated with risk of multiple sclerosis.

Zhou Y1, Zhu G2, Charlesworth JC1, Simpson S Jr1, Rubicz R3, Göring HH4, Patsopoulos NA5, Laverty C6, Wu F1, Henders A2, Ellis JJ2, van der Mei I1, Montgomery GW2, Blangero J4, Curran JE4, Johnson MP4, Martin NG2, Nyholt DR7, Taylor BV8; ANZgene consortium.
Multiple sclerosis (Houndmills, Basingstoke, England).Mult Scler.2016 Jan 27. pii: 1352458515626598. [Epub ahead of print]
BACKGROUND: Infection with the Epstein-Barr virus (EBV) is associated with an increased risk of multiple sclerosis (MS).OBJECTIVE: We sought genetic loci influencing EBV nuclear antigen-1 (EBNA-1) IgG titers and hypothesized that they may play a role in MS risk.METHODS: We performed a genome-wide as
PMID 26819262