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WordNet
- a solid formed by the solidification of a chemical and having a highly regular atomic structure
- a protective cover that protects the face of a watch (同)watch crystal, watch_glass
- a crystalline element used as a component in various electronic devices
- glassware made of quartz
- a rock formed by the solidification of a substance; has regularly repeating internal structure; external plane faces (同)crystallization
- French neurologist who tried to use hypnotism to cure hysteria (1825-1893) (同)Jean Martin Charcot
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- 〈U〉『水晶』 / 〈C〉『水晶製品』,水晶玉 / 〈U〉クリスタルグラス(透明度の高い鉛ガラス);《集合的に》クリスタルグラス製食器類(特にコップ類) / 〈C〉『結晶[体]』 / 〈C〉《米》(時計の)ガラスぶた / 『水晶[製]の』;クリスタルグラス製の;透き通った
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/07/12 17:08:30」(JST)
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Charcot–Leyden crystals and eosinophil granulocytes in allergic sinusitis.
Charcot–Leyden crystals are microscopic crystals found in people who have allergic diseases such as asthma or parasitic infections such as parasitic pneumonia or ascariasis.
The Charcot-Leyden crystal protein interacts with eosinophil lysophospholipases.[1]
Contents
- 1 Appearance
- 2 Clinical significance
- 3 History
- 4 See also
- 5 References
- 6 External links
Appearance
They vary in size and may be as large as 50 µm in length. Charcot–Leyden crystals are slender and pointed at both ends, consisting of a pair of hexagonal pyramids joined at their bases. Normally colorless, they are stained purplish-red by trichrome. They consist of lysophospholipase (galectin-10), an enzyme synthesized by eosinophils, and are produced from the breakdown of these cells.[1]
Clinical significance
They are indicative of a disease involving eosinophilic inflammation or proliferation, such as is found in allergic reactions and parasitic infections like Entamoeba histolytica.
Charcot–Leyden crystals are often seen pathologically in patients with bronchial asthma.
History
Friedrich Albert von Zenker was the first to notice these crystals, doing so in 1851, after which they were described jointly by Jean-Martin Charcot and Charles-Philippe Robin in 1853,[2] then in 1872 by Ernst Viktor von Leyden.[3]
See also
References
- ^ a b Ackerman SJ, Liu L, Kwatia MA, et al. (April 2002). "Charcot-Leyden crystal protein (galectin-10) is not a dual function galectin with lysophospholipase activity but binds a lysophospholipase inhibitor in a novel structural fashion". J. Biol. Chem. 277 (17): 14859–68. PMID 11834744. doi:10.1074/jbc.M200221200.
- ^ J. M. Charcot, C. P. Robin: Observation de leucocythémie. Comptes rendus de la Société de biologie, Paris, 1853, 44.
- ^ Ernst Victor von Leyden: Zur Kenntnis des Asthma bronchiale. [Virchows] Archiv für pathologische Anatomie und Physiologie, und für klinische Medizin, Berlin, 1872, 54: 324-344; 346-352.
External links
- Tulane Lung pathology
- Charcot Leyden crystals at UDEL
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Symptoms and signs relating to the respiratory system (R04–R07, 786)
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Medical examination and history taking
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| Auscultation |
- Stethoscope
- Respiratory sounds
- Stridor
- Wheeze
- Crackles
- Rhonchi
- Stertor
- Squawk
- Pleural friction rub
- Fremitus
- Bronchophony
- Terminal secretions
- Elicited findings
- Percussion
- Pectoriloquy
- Whispered pectoriloquy
- Egophony
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| Breathing |
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Rate
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- Apnea
- Dyspnea
- Hyperventilation
- Hypoventilation
- Hyperpnea
- Tachypnea
- Hypopnea
- Bradypnea
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Pattern
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- Agonal respiration
- Biot's respiration
- Cheyne–Stokes respiration
- Kussmaul breathing
- Ataxic respiration
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Other
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- Respiratory distress
- Respiratory arrest
- Orthopnea/Platypnea
- Trepopnea
- Aerophagia
- Asphyxia
- Breath holding
- Mouth breathing
- Snoring
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| Other |
- Chest pain
- In children
- Precordial catch syndrome
- Pleurisy
- Clubbing/Hippocratic fingers (Schamroth's window test)
- Cyanosis
- Cough
- Sputum
- Hemoptysis
- Epistaxis
- Silhouette sign
- Post-nasal drip
- Hiccup
- COPD
- asthma
- Curschmann's spirals
- Charcot–Leyden crystals
- chronic bronchitis
- sarcoidosis
- pulmonary embolism
- Hampton hump
- Westermark sign
- pulmonary edema
- Hamman's sign
- Golden S sign
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UpToDate Contents
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- 1. 好酸球性胃腸炎eosinophilic gastroenteritis [show details]
…testing. In addition, stool examination in patients with a parasitic infection may reveal Charcot-Leyden crystals, which are the product of eosinophil granules. Malignancy – Lymphoma, gastric cancer,…
- 2. 肺好酸球増多症の概要overview of pulmonary eosinophilia [show details]
…breathing. Dyspnea, wheezing, fever, and blood-tinged sputum containing eosinophil-derived Charcot-Leyden crystals may also be present The chest radiograph may show round or oval opacities ranging in size…
- 3. 回虫症ascariasis [show details]
…is masked by administration of steroids. Sputum analysis may demonstrate eosinophils and Charcot-Leyden crystals . These crystals are also observed in other eosinophilic parasitic lung infections. Serum…
- 4. 食物蛋白誘発胃腸炎（新生児-乳児消化管アレルギー）（FPIES）food protein induced enterocolitis syndrome fpies [show details]
…examination were nonspecific, showing occult blood, polymorphonuclear neutrophils, eosinophils, Charcot-Leyden crystals, and reducing substances . Stool contained frank or occult blood, mucus, sheets of leukocytes…
- 5. アレルギー性気管支肺アスペルギルス症の臨床症状および診断clinical manifestations and diagnosis of allergic bronchopulmonary aspergillosis [show details]
…variety of processes . Expectorated sputum may contain "plugs" with eosinophils, Charcot-Leyden crystals, and may grow Aspergillus in culture . Central bronchiectasis is a frequent feature of ABPA…
English Journal
- Allergic Fungal Sinusitis.
- Correll DP1, Luzi SA2, Nelson BL2.
- Head and neck pathology.Head Neck Pathol.2015 Dec;9(4):488-91. doi: 10.1007/s12105-014-0598-5. Epub 2014 Dec 24.
- A 42 year old male presents with worsening pain and an increase in thick chronic drainage of the left sinus. Image studies show complete opacification of the left frontal sinus, left sphenoid sinus, and the left maxillary sinus. The patient was taken to the operating room and tissue for microscopic
- PMID 25537829
- A Single Aspiration of Rod-like Carbon Nanotubes Induces Asbestos-like Pulmonary Inflammation Mediated in Part by the IL-1 Receptor.
- Rydman EM1, Ilves M1, Vanhala E1, Vippola M2, Lehto M1, Kinaret PA1, Pylkkänen L1, Happo M3, Hirvonen MR3, Greco D1, Savolainen K1, Wolff H1, Alenius H4.
- Toxicological sciences : an official journal of the Society of Toxicology.Toxicol Sci.2015 Sep;147(1):140-55. doi: 10.1093/toxsci/kfv112. Epub 2015 Jun 5.
- Carbon nanotubes (CNT) have been eagerly studied because of their multiple applications in product development and potential risks on health. We investigated the difference of two different CNT and asbestos in inducing proinflammatory reactions in C57BL/6 mice after single pharyngeal aspiration expo
- PMID 26048651
- Charcot-Leyden crystals in acute myeloid leukemia.
- van de Kerkhof D1, Scharnhorst V2, Huysentruyt CJ3, Brands-Nijenhuis AV4, Ermens AA5.
- International journal of laboratory hematology.Int J Lab Hematol.2015 Aug;37(4):e100-2. doi: 10.1111/ijlh.12336. Epub 2015 Mar 9.
- PMID 25754678
Japanese Journal
- 症例報告 喀痰のグラム染色所見とコロニーの染色所見よりSchizophyllum commune(スエヒロタケ)感染症によるアレルギー性気管支肺真菌症(allergic bronchopulumonary mycosis, ABPM)が、最も疑われた1症例
- 気管支肺胞洗浄液細胞診が有用であったアレルギー性気管支肺アスペルギルス症の 1 例
- Acute Myeloid Leukemia-associated Charcot-Leyden Crystals in the Bone Marrow
Related Links
- Charcot-Leyden crystals are microscopic crystals found in people who have allergic diseases such as asthma or parasitic infections such as parasitic ... The Charcot-Leyden crystal protein interacts with eosinophil lysophospholipases.
- Charcot-Leyden crystals are formed from the breakdown of eosinophils and may be seen in the stool or sputum of patients with parasitic diseases. The crystals are slender and pointed and stain purplish-red in the trichrome stain, as shown in ...
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