Effects of quercetin on Aroclor 1254-induced expression of CYP and cytokines in pregnant rats.
Xu L, Guo X, Li N, Pan Q, Ma YZ.
Journal of immunotoxicology. 2019 Dec;16(1)140-148.
The present study aimed to investigate the protective effect of quercetin on polychlorinated biphenyls (PCB)-induced liver and embryo damage in pregnant Sprague-Dawley rats. Pregnant rats were divided into five groups, and then were orally gavaged daily with peanut oil (vehicle) or a commercial PCB
Age-associated changes of cytochrome P450 and related phase-2 gene/proteins in livers of rats.
Xu SF, Hu AL, Xie L, Liu JJ, Wu Q, Liu J.
PeerJ. 2019 ;7()e7429.
Cytochrome P450s (CYPs) are phase-I metabolic enzymes playing important roles in drug metabolism, dietary chemicals and endogenous molecules. Age is a key factor influencing P450s expression. Thus, age-related changes of CYP 1-4 families and bile acid homeostasis-related CYPs, the corresponding nucl
Enhanced Platelet Response to Clopidogrel in Zucker Diabetic Fatty Rats due to Impaired Clopidogrel Inactivation by Carboxylesterase 1 and Increased Exposure to Active Metabolite.
Yao H, Bai R, Ren T, Wang Y, Gu J, Guo Y.
Drug metabolism and disposition: the biological fate of chemicals. 2019 Aug;47(8)794-801.
Clopidogrel (Clop), a thienopyridine antiplatelet prodrug, is metabolized by cytochrome P450s (CYPs) to an active metabolite, Clop-AM, and hydrolyzed by carboxylesterase (CES)1 to the inactive Clop-acid. Patients with type 2 diabetes (T2DM) tend to have a poor response to Clop due to reduced generat
Journal of Veterinary Medical Science advpub(0), 1109270637, 2011
… This study examined which prenatal DES treatment influenced hepatic microsomal enzymes, CYP3A1, CYP2B1/2, CYP2C11, UGT2B1 (UDP-glucuronosyltransferase 2B1), and IGF-1 (insulin-like growth factor-1), in male offspring. … DES treatment decreased the mRNA expression levels of CYP3A1 and CYP2B1/2, but did not alter the expression of CYP2C11. …
The Journal of Toxicological Sciences 36(5), 613-623, 2011
… The induction of liver hypertrophy and hepatic cytochrome P450 (CYP) isoforms (CYP2B1/2B2 for PB and CYP4A1 for CF) by PB and CF were clearly observed at all the treatment periods examined. …
Evaluation of liver and thyroid toxicity in Sprague-Dawley rats after exposure to polybrominated diphenyl ether BDE-209
LEE Ena,KIM Tae Hyung,CHOI Jae Seok,NABANATA Patra,KIM Na Young,AHN Mee Young,JUNG Ki Kyung,KANG Il Hyun,KIM Tae Sung,KWACK Seung Jun,PARK Kui Lea,KIM Seung Hee,KANG Tae Seok,LEE Jaewon,LEE Byung Mu,KIM Hyung Sik
Journal of toxicological sciences 35(4), 535-545, 2010-08-01
… BDE-209 significantly induced the expression of cytochrome P450 (CYP1A2, CYP3A1, and CYP2B1) enzymes in the liver. …
CYP2B1/2B2 Antibody (9.14) is a mouse monoclonal IgG 1 provided at 200 µg/ml raised against liver cytochrome P4502B1 and 2B2 of rat origin recommended for detection of CYP2B1 and CYP2B2 of mouse and rat origin by WB and ...
Buy CYP2B1 antibody / CYP2B1 antibodies from Santa Cruz Biotechnology. Monoclonal and polyclonal antibodies are available to most protein immunogen targets. ... Primary Antibodies: Mammalian リン酸化型特異的抗体 Antibodies for IHC (Paraffin) Staining ...