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1. 全身化学療法に対する輸注反応 infusion reactions to systemic chemotherapy
2. 転移性乳癌の全身治療：単剤化学療法 systemic treatment for metastatic breast cancer single agent chemotherapy
3. アナフィラキシーの病態生理 pathophysiology of anaphylaxis
4. タキサン誘発性肺毒性 taxane induced pulmonary toxicity
5. 抗腫瘍療法関連肺毒性：細胞傷害性薬物 pulmonary toxicity associated with antineoplastic therapy cytotoxic agents

Sirolimus solid self-microemulsifying pellets: Formulation development, characterization and bioavailability evaluation.

Hu X, Lin C, Chen D, Zhang J, Liu Z, Wu W, Song H.SourceDepartment of Pharmacy, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China; School of Pharmacy, Fudan University, Shanghai 201203,China.
International journal of pharmaceutics.Int J Pharm.2012 Nov 15;438(1-2):123-33. doi: 10.1016/j.ijpharm.2012.07.055. Epub 2012 Jul 28.
To enhance the dissolution and oral absorption of water insoluble drug sirolimus (SRL), self-microemulsifying pellets of SRL were developed and evaluated. Solubility test, self-emulsifying grading test, ternary phase diagrams and central composite design were adopted to screen and optimize the compo
PMID 22850296

Application of Langmuir-Blodgett film technology on studying the formulation of self-microemulsifying drug delivery system (SMEDDS).

Yang X, Ge M, Wang T, Quan D.SourceBeijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850, China.
International journal of pharmaceutics.Int J Pharm.2012 Nov 1;437(1-2):100-2. doi: 10.1016/j.ijpharm.2012.07.044. Epub 2012 Jul 31.
The polarity of oleic acid, medium-chain triglyceride and their mixtures with different ratios was determined by LB film technology. Then the particle diameter after emulsifying in water when these different oils were mixed with Cremophor EL-35 respectively was assayed. Then three formulations of SM
PMID 22868235

Miyamoto Ken-ichi,Shimada Tsutomu,Sawamoto Kazuki,Sai Yoshimichi,Yonemura Yutaka
Gastroenterology Research and Practice (2012), 963403, 2012
… They are administered as micellar preparations, Taxol and Taxotere, which consist of paclitaxel in Cremophor EL (crEL) and docetaxel in Polysorbate-80 (PS-80), respectively. …
NAID 120004419377

Surfactants influence the distribution of taxanes in peritoneal dissemination tumor-bearing rats.

Kamijo Yukio,Ito Chie,Nomura Masaaki,Sai Yoshimichi,Miyamoto Kenichi
Cancer Letter 287(2), 182-186, 2010-01-28
… The in vitro uptake of paclitaxel by AH130 cells was inhibited by Cremophor EL and Polysorbate-80. …
NAID 120001871357