COL4A3 gene

WordNet

1. (genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
2. informal term for information; "give me the gen on your new line of computers"

PrepTutorEJDIC

1. 遺伝子

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• 1. 遺伝性腎炎（アルポート症候群）の臨床症状、診断および治療 clinical manifestations diagnosis and treatment of hereditary nephritis alport syndrome
• 2. 爪膝蓋骨症候群 nail patella syndrome
• 3. 遺伝性腎炎（アルポート症候群）の遺伝学、病因、および病理 genetics pathogenesis and pathology of hereditary nephritis alport syndrome
• 4. 抗GBM抗体（グッドパスチャー）病の病因および診断 pathogenesis and diagnosis of anti gbm antibody goodpastures disease
• 5. 菲薄基底膜腎症（良性家族性血尿） thin basement membrane nephropathy benign familial hematuria

English Journal

• Characterization of the intrarenal renin-angiotensin system in experimental alport syndrome.

• Bae EH1, Konvalinka A2, Fang F3, Zhou X3, Williams V3, Maksimowski N3, Song X4, Zhang SL5, John R6, Oudit GY7, Pei Y4, Scholey JW8.
• The American journal of pathology.Am J Pathol.2015 May;185(5):1423-35. doi: 10.1016/j.ajpath.2015.01.021. Epub 2015 Mar 14.
• Blockade of the renin-angiotensin system attenuates the progression of experimental and clinical Alport syndrome (AS); however, the underlying mechanism(s) remains largely unknown. We evaluated the renin-angiotensin system in 4- and 7-week-old homozygous for collagen, type IV, α3 gene (Col4A3(-/-))
• PMID 25777062

• Extracellular vesicles derived from renal cancer stem cells induce a pro-tumorigenic phenotype in mesenchymal stromal cells.

• Lindoso RS1,2, Collino F1,3, Camussi G1.
• Oncotarget.Oncotarget.2015 Apr 10;6(10):7959-69.
• Renal carcinomas have been shown to contain a population of cancer stem cells (CSCs) that present self-renewing capacity and support tumor growth and metastasis. CSCs were shown to secrete large amount of extracellular vesicles (EVs) that can transfer several molecules (proteins, lipids and nucleic
• PMID 25797265

Japanese Journal

• 常染色体性 Alport 症候群

• 岡 政史,野津 寛大,飯島 一誠,松尾 雅文
• 日本小児腎臓病学会雑誌 = Japanese journal of pediatric nephrology 23(1), 8-12, 2010-04-15
• 　Alport症候群 (AS) は感音性難聴を伴う遺伝性進行性腎疾患である。高頻度に末期腎不全に至るとされ臨床的に重要な疾患であるが，その臨床像，自然予後は十分には解明されていない。今回，分子遺伝学的特徴および近年報告された家族性良性血尿症候群との関連について，常染色体性Alport症候群を中心に概要をまとめる。
• NAID 10026412082

Related Links

• COL4A3 - collagen, type IV, alpha 3 (Goodpasture antigen ...

More than 40 mutations in the COL4A3 gene have been found to cause Alport syndrome. Most of these mutations change single protein building blocks (amino acids) in a region where the alpha3(IV) collagen ...