WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

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1. 虚血後の急性尿細管壊死の発症機序および病因 pathogenesis and etiology of postischemic acute tubular necrosis
2. 結核の免疫学 immunology of tuberculosis
3. サルコイドーシスの臨床症状および診断 clinical manifestations and diagnosis of sarcoidosis
4. 移植免疫 transplantation immunobiology
5. ヘルパーT細胞サブセット：疾患における分化および役割 t helper subsets differentiation and role in disease

Overexpression of the monocyte chemokine CCL2 in dorsal root ganglion neurons causes a conditioning-like increase in neurite outgrowth and does so via a STAT3 dependent mechanism.

Niemi JP1, DeFrancesco-Lisowitz A1, Cregg JM1, Howarth M1, Zigmond RE2.
Experimental neurology.Exp Neurol.2016 Jan;275 Pt 1:25-37. doi: 10.1016/j.expneurol.2015.09.018. Epub 2015 Nov 2.
Neuroinflammation plays a critical role in the regeneration of peripheral nerves following axotomy. An injury to the sciatic nerve leads to significant macrophage accumulation in the L5 DRG, an effect not seen when the dorsal root is injured. We recently demonstrated that this accumulation around ax
PMID 26431741

CX3CR1hi Monocytes Support Bacterial Survival and Experimental Infection-driven Bone Resorption.

Steinmetz O1, Hoch S1, Avniel-Polak S1, Gavish K1, Eli-Berchoer L1, Wilensky A2, Nussbaum G1.
The Journal of infectious diseases.J Infect Dis.2015 Dec 23. pii: jiv763. [Epub ahead of print]
Porphyromonas gingivalis, an anaerobic bacterium strongly linked to infection-driven inflammatory bone erosion, thrives within a highly inflamed milieu, and disseminates to distant sites such as atherosclerotic plaque. We examined the role of monocyte/macrophages in determining the outcome of infect
PMID 26704610

Heme oxygenase-1 suppresses a pro-inflammatory phenotype in monocytes and determines endothelial function and arterial hypertension in mice and humans.

Wenzel P1, Rossmann H2, Müller C3, Kossmann S4, Oelze M5, Schulz A5, Arnold N5, Simsek C5, Lagrange J6, Klemz R7, Schönfelder T6, Brandt M5, Karbach SH5, Knorr M5, Finger S6, Neukirch C2, Häuser F2, Beutel ME8, Kröller-Schön S5, Schulz E5, Schnabel RB3, Lackner K2, Wild PS9, Zeller T3, Daiber A5, Blankenberg S3, Münzel T10.
European heart journal.Eur Heart J.2015 Dec 21;36(48):3437-46. doi: 10.1093/eurheartj/ehv544. Epub 2015 Oct 29.
AIMS: Heme oxygenase-1 (HO-1) confers protection to the vasculature and suppresses inflammatory properties of monocytes and macrophages. It is unclear how HO-1 determines the extent of vascular dysfunction in mice and humans.METHODS AND RESULTS: Decreased HO-1 activity and expression was paralleled
PMID 26516175

A Novel C–C Chemokine Receptor 2 Antagonist Prevents Progression of Albuminuria and Atherosclerosis in Mouse Models

Okamoto Masayuki,Fuchigami Masahiro,Suzuki Takeshi [他],Watanabe Nobuhide
Biological and Pharmaceutical Bulletin 35(11), 2069-2074, 2012
… C–C chemokine ligand 2 (CCL2)/its receptor (CCR2) axis is considered as an important signaling pathway in inflammatory diseases. … TLK-19705 is a novel CCR2 antagonist, (1-(1,3-dimethyl-1-H-pyrazolo[3,4-b]pyridine-5-carbonyl)-3-(4-fluoro-3-(trifluoromethyl)phenyl)urea), and the inhibitory activity was antagonized by the third extracellular loop peptide of CCR2. …
NAID 130001872265

Ablation of the Ccr2 gene exacerbates polyarthritis in interleukin-1 receptor antagonist-deficient mice

Fujii Hiroshi,Baba Tomohisa,Ishida Yuko,Kondo Toshikazu,Yamagishi Masakazu,Kawano Mitsuhiro,Mukaida Naofumi
Arthritis and Rheumatism 63(1), 96-106, 2011-01-00
… Given the role of intraarticular macrophage infiltration in RA, this study was undertaken to address the pathogenic role of CCR2, a chemokine receptor that is abundantly expressed by macrophages, in Il1rn-deficient mice, a mouse model of RA. … Methods Il1rn-deficient and Il1rn and Ccr2-double-deficient mice were subjected to clinical assessment of arthritis and histologic examination. …
NAID 120002754103