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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/27 12:32:49」(JST)

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Chemokine (C-C motif) ligand 24 (CCL24) also known as myeloid progenitor inhibitory factor 2 (MPIF-2) or eosinophil chemotactic protein 2 (eotaxin-2) is a protein that in humans is encoded by the CCL24 gene.^[1] This gene is located on human chromosome 7.^[2]

Function

CCL24 is a small cytokine belonging to the CC chemokine family. CCL24 interacts with chemokine receptor CCR3 to induce chemotaxis in eosinophils.^[3] This chemokine is also strongly chemotactic for resting T lymphocytes and slightly chemotactic for neutrophils.^[1]

Clinical significance

Elevated levels of eotaxin-2 has been seen in patients with aspirin-exacerbated respiratory disease (AERD), such as asthma. People with lower plasma levels of eotaxin-2 have not been showing tendency to develop aspirin inducible asthma.^[4]

References

^ ^a ^b Patel VP, Kreider BL, Li Y, Li H, Leung K, Salcedo T, Nardelli B, Pippalla V, Gentz S, Thotakura R, Parmelee D, Gentz R, Garotta G (April 1997). "Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors". J. Exp. Med. 185 (7): 1163–72. doi:10.1084/jem.185.7.1163. PMC 2196270. PMID 9104803.
^ Hillier LW, Fulton RS, Fulton LA, et al. (July 2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
^ White JR, Imburgia C, Dul E, Appelbaum E, O'Donnell K, O'Shannessy DJ, Brawner M, Fornwald J, Adamou J, Elshourbagy NA, Kaiser K, Foley JJ, Schmidt DB, Johanson K, Macphee C, Moores K, McNulty D, Scott GF, Schleimer RP, Sarau HM (November 1997). "Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils". J. Leukoc. Biol. 62 (5): 667–75. PMID 9365122.
^ Palikhe NS, Kim SH, Cho BY, Ye YM, Choi GS, Park HS (October 2009). "Genetic variability in CRTH2 polymorphism increases eotaxin-2 levels in patients with aspirin exacerbated respiratory disease". Allergy 65 (3): 338–346. doi:10.1111/j.1398-9995.2009.02158.x. PMID 19796209.

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UpToDate Contents

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1. 胸水中の好酸球増加 pleural fluid eosinophilia

English Journal

Comparative study of various growth factors and cytokines on type I collagen and hyaluronan production in human dermal fibroblasts.

Kim MS1, Song HJ, Lee SH, Lee CK.Author information 1R&D Center, LG Household & Healthcare Ltd., Daejeon, Korea.AbstractBACKGROUND: Dermal fibroblast is a primary cell type responsible for synthesis and remodeling of extracellular matrix in human skin. Type I collagen and hyaluronan are main components that have roles in skin fibrosis, wound healing, tissue remodeling as well as skin aging. Several studies have reported cytokine-dependent changes in collagen expression or hyaluronan production; however, the cytokines' effect was controversial in human dermal fibroblasts.
Journal of cosmetic dermatology.J Cosmet Dermatol.2014 Mar;13(1):44-51. doi: 10.1111/jocd.12073.
BACKGROUND: Dermal fibroblast is a primary cell type responsible for synthesis and remodeling of extracellular matrix in human skin. Type I collagen and hyaluronan are main components that have roles in skin fibrosis, wound healing, tissue remodeling as well as skin aging. Several studies have repor
PMID 24641605

Distinctive cytokine, chemokine, and antibody responses in Echinococcus multilocularis-infected patients with cured, stable, or progressive disease.

Huang X1, Grüner B, Lechner CJ, Kern P, Soboslay PT.Author information 1Institute for Tropical Medicine, University of Tübingen, Wilhelmstraße 27, 72074, Tübingen, Germany.AbstractMetacestode larvae of the tapeworm Echinococcus multilocularis can cause alveolar echinococcosis (AE), a severe parasitic disease in man, which, if it remains untreated, may cause organ failure and death. Spontaneous and parasite antigen-induced cellular responses were studied in patients with cured, stable, and progressive AE to differentiate the response profiles between the distinct states of infection. Antibody reactivity was evaluated in AE patients with cured, stable, and progressive disease. The spontaneous cellular release of pro-inflammatory IL-31 and IL-33 was clearly depressed in all AE patients, while regulatory IL-27, anti-inflammatory SDF-1/CXCL12, and eosinophil granulocyte attracting Eotaxin-1, Eotaxin-2, and Eotaxin-3 (CCL11, CCL24, CCL26) were enhanced with disease progression. Such distinctive response profiles could be applied for monitoring of AE disease progression or regression. E. multilocularis metacestode (Em) antigens (entire metacestode EmAg as well as EmVesicles) stimulated in vitro IL-31, IL-33, Eotaxin-1, Eotaxin-3, and CXCL12 cytokine and chemokine responses, which were similarly present in all AE patient groups, while regulatory IL-27 was suppressed and pro-inflammatory Eotaxin-2 was enhanced. E. multilocularis metacestode-specific IgG1, IgG3, and IgE responses progressively diminished with regression from active to stable and cured AE. IgG2 and IgG4 reactivity remained similarly high in stable and progressive cases, and lessened only with cured AE. Antibody reactivity against E. multilocularis vesicle antigen distinctively separated between cured, stable, or progressive AE, with the exception of IgG4. In sum, the combined and longitudinal study of several cytokines and chemokines, together with the evaluation of E. multilocularis vesicle-specific antibody responses, should provide a better understanding of the immune response during progression and regression of AE, and may help to improve the staging of AE patients.
Medical microbiology and immunology.Med Microbiol Immunol.2014 Feb 9. [Epub ahead of print]
Metacestode larvae of the tapeworm Echinococcus multilocularis can cause alveolar echinococcosis (AE), a severe parasitic disease in man, which, if it remains untreated, may cause organ failure and death. Spontaneous and parasite antigen-induced cellular responses were studied in patients with cured
PMID 24509604

Japanese Journal

Eosinophils facilitate antigen-specific T-cell proliferation and aggravate antigen-induced arthritis.

Saika Taro
Kawasaki medical journal 40(1), 13-22, 2014
… We also analyzed the gene expression of pro-inflammatory cytokines (IL-1β, IL-6, TNFα , and IL-17 ), Th1/Th2 cytokine (IFNγ and IL-13 ), and mediators that increase eosinophils (IL-5, IL-33, GM-CSF, CCL11, CCL24, CCL26, and RANTES ) in the synovium of the knee joints. …
NAID 110009807868

A Novel CC-Chemokine Receptor 3 Antagonist, Ki19003, Inhibits Airway Eosinophilia and Subepithelial/Peribronchial Fibrosis Induced by Repeated Antigen Challenge in Mice

, , [他], , , , , , , , , ,
Journal of pharmacological sciences 112(2), 203-213, 2010-02-20
… CC-chemokine receptor 3 (CCR3) is a chemokine receptor for which major ligands, CC-chemokine ligand (CCL) 11, CCL24, and CCL26, are known to be involved in chemotaxis for eosinophils. …
NAID 10029888930

イヌのアトピー性皮膚炎病変部および非病変部におけるCCL27およびCCL28 mRNAの発現解析(内科学)

前田貞俊,土田宏美,柴田早苗 [他],川上哲司,津久井利広,大場恵典,深田恒夫,北川均
The journal of veterinary medical science 70(1), 51-55, 2008-01-25
ケモカインはアレルギー炎症部への炎症細胞の選択的遊走の制御に重要な役割を果たしている.イヌのアトピー性皮膚炎(AD)はヒトADと多くの臨床的特徴を共有していることから,イヌにおけるケモカイン産生パターンはヒトのものに類似している可能性がある.本研究では,イヌおよびヒトADのケモカイン産生に関する類似性を明らかにすることを目的とし,イヌAD病変部におけるCCL27およびCCL28 mRNAの発現を評 …
NAID 110006546637

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★リンクテーブル★

リンク元	「Eotaxin 2」
関連記事	「CCL」

「Eotaxin 2」

chemokine (C-C motif) ligand 24
Identifiers
Symbol	CCL24
Alt. symbols	SCYA24, Ckb-6, MPIF-2, eotaxin-2
Entrez	6369
HUGO	10623
OMIM	602495
PDB	1EIG (RCSB PDB PDBe PDBj)
RefSeq	NM_002991
UniProt	O00175
Other data
Locus	Chr. 7 q11.23