関: B. bronchiseptica

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/16 17:56:09」(JST)

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気管支敗血症菌（Bordetella bronchiseptica、ボルデテラ・ブロンキセプティカ）とはボルデテラ属(Bordetella)に属する細菌であり、感染性気管支炎の原因となる^[1]。気管支敗血症菌は長期間生活環境で持続することができ^[2]、ヒトに固有の百日咳を引き起こす百日咳菌(Bordetella pertussis)と近縁である^[3]。

病原性

B. pertussisやB. parapertussisとは異なり、B. bronchisepticaはヒトへは感染せず、ネコ、イヌ、ウサギなどの小型の哺乳類の気道に感染する^[3]。

B. bronchisepticaはB. pertussisの特徴である百日咳毒素(en:pertussis toxin)を発現しないが、遺伝子によると両者は非常に近縁である。^[4]^,^[5]

動物における病原性

獣医学において、B. bronchisepticaは複数種の動物を宿主として病原性を示す。B. bronchisepticaとPasteurella multocidaの混合感染は発育阻害や鼻甲介の変形を引き起こす豚萎縮性鼻炎の原因となる^[6]。B. bronchiseptica はイヌやウサギにおける急性気管気管支炎の原因となる^[7]。B. bronchisepticaは鼻道においてよく見つけられる。B. bronchisepticaはスナッフルとして知られている無症状様感染症の原因と誤解されるが、実際はPseudomonas multocidaとB. bronchisepticaが同時に鼻腔に混合感染することを原因とする^[8]。

脚注

^ Ryan KJ; Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed. ed.). McGraw Hill. ISBN 0-8385-8529-9.
^ Coote JG (2001). “Environmental sensing mechanisms in Bordetella”. Adv Microb Physiol 44: 141-81. PMID 11407112.
^ ^a ^b Finger H, von Koenig CHW (1996). Bordetella. In: Barron's Medical Microbiology (Barron S et al, eds.) (4th ed. ed.). Univ of Texas Medical Branch. (via NCBI Bookshelf) ISBN 0-9631172-1-1.
^ Mattoo S, Foreman-Wykert AK, Cotter PA, Miller JF (2001). “Mechanisms of Bordetella pathogenesis”. Front Biosci 6: E168-86. doi:10.2741/Mattoo. PMID 11689354.
^ Diavatopoulos DA, Cummings CA, Schouls LM, Brinig MM, Relman DA, Mooi FR (2005). “Bordetella pertussis, the Causative Agent of Whooping Cough, Evolved from a Distinct, Human-Associated Lineage of B. bronchiseptica”. PLoS Pathog 1 (4): e45. doi:10.1371/journal.ppat.0010045. PMID 16389302.
^ Lawhorn, Bruce. “Atrophic Rhinitis (PDF)”. Texas Agricultural Extension Service. 2006年11月23日閲覧。
^ Wagener, J. S., R. Sobonya, L. Minnich and L. M. Taussig (1984). Role of canine parainfluenza virus and Bordetella bronchiseptica in kennel cough. Am J Vet Res 45(9): 1862-6.
^ Burns, E. H., Jr., J. M. Norman, M. D. Hatcher and D. A. Bemis (1993). Fimbriae and determination of host species specificity of Bordetella bronchiseptica. J Clin Microbiol 31(7): 1838-44

wiki en

[Wiki en表示]

Bordetella bronchiseptica is a small, Gram-negative, rod-shaped bacterium of the genus Bordetella.^[1] It can cause infectious bronchitis in dogs and other animals, ^[2] but rarely infects humans.^[3] Closely related to B. pertussis^[4]—the obligate human pathogen that causes pertussis (whooping cough); B. bronchiseptica can persist in the environment for extended periods.^[5]

Pathogenesis

Humans are not natural carriers of B. bronchiseptica, which typically infects the respiratory tracts of smaller mammals (cats, dogs, rabbits, etc.).^[4] People are more likely to be infected by B. pertussis or B. parapertussis. Unlike B. pertussis, B. bronchiseptica is generally resistant to macrolide antibiotics. It is also generally resistant to cephalosporins. Some human cases have been successfully treated with trimethoprim/sulfamethoxazole and fluoroquinolones.

B. bronchiseptica does not express pertussis toxin, which is one of the characteristic virulence factors of B. pertussis, but it has the genes to do so, highlighting the close evolutionary relationship between the two species.^[6]^,^[7]

Veterinary pathogenesis

A scanning electron micrograph depicted a number of Gram-negative Bordetella bronchiseptica bacteria

In veterinary medicine, B. bronchiseptica leads to a range of pathologies in different hosts. It is a serious disease of dogs, pigs, and rabbits, and has been seen in cats, horses, and seals. A PCR test for the pathogen exists.^[8]

In pigs, B. bronchiseptica and Pasteurella multocida act synergistically to cause atrophic rhinitis, a disease resulting in arrested growth and distortion of the turbinates in the nasal terminus (snout).^[9]

In dogs, B. bronchiseptica causes acute tracheobronchitis,^[10] which typically has a harsh, honking cough. Kennel cough can also be caused by canine adenovirus-2 or canine parainfluenza virus or a combination of pathogens.^[8]

In rabbits, B. bronchiseptica is often found in the nasal tract. It is often assumed to cause a nearly asymptomatic infection known as snuffles, but the causative agent for that disease is Pasteurella multocida; B. bronchiseptica often co-infects the nasal passage at the same time.^[11]

Cats infected with B. bronchiseptica have been seen with tracheobronchitis, conjunctivitis, and rhinitis (upper respiratory tract infection - URI), mandibular lymphadenopathy, and pneumonia. However, URI in cats can also be caused by herpesvirus, calicivirus, Mycoplasma species, or Chlamydia psittaci.^[8] An intranasal vaccine exists for cats.^[12]

References

^ Hewlett, EL (1995). "Bordetella species." In: Principles and Practice of Infectious Diseases (Mandel, GL, Bennett, JE, Dolin, R, eds.). Churchill Livingston, Inc., New York, NY. pp. 2078–2084.
^ Pedro-Pons, Agustín (1968). Patología y Clínica Médicas (in Spanish) 6 (3rd ed.). Barcelona: Salvat. p. 613. ISBN 84-345-1106-1.
^ Ryan KJ; Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. ISBN 0-8385-8529-9.
^ ^a ^b Finger H, von Koenig CHW (1996). Bordetella. In: Barron's Medical Microbiology (Barron S et al., eds.) (4th ed.). Univ of Texas Medical Branch. (via NCBI Bookshelf) ISBN 0-9631172-1-1.
^ Coote JG (2001). "Environmental sensing mechanisms in Bordetella". Adv Microb Physiol 44: 141–81. doi:10.1016/S0065-2911(01)44013-6. PMID 11407112.
^ Mattoo S, Foreman-Wykert AK, Cotter PA, Miller JF (2001). "Mechanisms of Bordetella pathogenesis". Front Biosci 6: E168–86. doi:10.2741/Mattoo. PMID 11689354.
^ Diavatopoulos DA, Cummings CA, Schouls LM, Brinig MM, Relman DA, Mooi FR (2005). "Bordetella pertussis, the Causative Agent of Whooping Cough, Evolved from a Distinct, Human-Associated Lineage of B. bronchiseptica". PLoS Pathog 1 (4): e45. doi:10.1371/journal.ppat.0010045. PMC 1323478. PMID 16389302.
^ ^a ^b ^c "Bordetella data sheet". Zoologix. Retrieved 2009-03-08.
^ Lawhorn, Bruce. "Atrophic Rhinitis" (PDF). Texas Agricultural Extension Service. Retrieved 2006-11-23. ^{[dead link]}
^ Wagener, J. S., R. Sobonya, L. Minnich and L. M. Taussig (1984). Role of canine parainfluenza virus and Bordetella bronchiseptica in kennel cough. Am J Vet Res 45(9): 1862-6.
^ Burns, E. H., Jr., J. M. Norman, M. D. Hatcher and D. A. Bemis (1993). Fimbriae and determination of host species specificity of Bordetella bronchiseptica. J Clin Microbiol 31(7): 1838-44
^ "Prevention and control of Bordetella bronchiseptica infection in cats". Intervet/Schering-Plough Animal Health. Retrieved 2009-03-08.

External links

Material Safety Data Sheet (MSDS) for Bordetella bronchiseptica (Public Health Agency of Canada)
Genetic sequences of the Bordetella bronchiseptica complex (Sanger Institute)

UpToDate Contents

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1. 犬からの人畜共通感染症 zoonoses from dogs
2. 百日咳菌感染症：疫学、微生物学、および病因 bordetella pertussis infection epidemiology microbiology and pathogenesis
3. 猫からの人畜共通感染症 zoonoses from cats
4. 思春期および成人における百日咳菌感染症：臨床症状および診断 bordetella pertussis infection in adolescents and adults clinical manifestations and diagnosis
5. 犬および猫以外のペットからの人畜共通感染症 zoonoses from pets other than dogs and cats

English Journal

Susceptibility of canine and feline bacterial pathogens to pradofloxacin and comparison with other fluoroquinolones approved for companion animals.

Schink AK, Kadlec K, Hauschild T, Brenner Michael G, Dörner JC, Ludwig C, Werckenthin C, Hehnen HR, Stephan B, Schwarz S.SourceInstitute of Farm Animal Genetics, Friedrich-Loeffler-Institut (FLI), Neustadt-Mariensee, Germany.
Veterinary microbiology.Vet Microbiol.2013 Feb 22;162(1):119-26. doi: 10.1016/j.vetmic.2012.08.001. Epub 2012 Aug 8.
In this study, 908 bacterial pathogens from defined infections of dogs and cats were tested for their susceptibility to the novel fluoroquinolone pradofloxacin, which was approved in 2011 for use in cats and dogs. Most of the bacteria tested (Staphylococcus aureus, Staphylococcus pseudintermedius, E
PMID 22939523

An improved RIVET-like reporter system reveals differential cyaA gene activation in Bordetella species.

Byrd MS, Mason E, Henderson MW, Scheller EV, Cotter PA.SourceDepartment of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599.
Infection and immunity.Infect Immun.2013 Feb 4. [Epub ahead of print]
Bordetella pertussis and Bordetella bronchiseptica rely on the global two-component regulatory system BvgAS to control expression of distinct phenotypic phases. In the Bvg(-) phase, expression of vrg genes, including those required for motility in B. bronchiseptica, is activated and genes encoding v
PMID 23381998

aroA deleted Bordetella bronchiseptica inspiring robust mucosal immune response and provide full protection against intranasal challenge.

Zhang Q, Hu R, Hu J, He H, Tang X, Jin M, Chen H, Wu B.SourceDivision of Animal Infectious Diseases, State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Research in veterinary science.Res Vet Sci.2013 Feb;94(1):55-61. doi: 10.1016/j.rvsc.2012.07.019. Epub 2012 Aug 11.
Bordetella bronchiseptica is a Gram-negative respiratory pathogen responsible for atrophic rhinitis and bronchopneumonia in swine. Several vaccines aimed at preventing B. bronchiseptica have been used, but a safe and efficient live vaccine for use in piglets remains elusive. In this study, we constr
PMID 22892249

Japanese Journal

国内における犬呼吸器感染症の病原学的調査

勢籏剛,若月章,増渕勝夫,高橋拓男,国分輝秋
日本獣医師会雑誌 = Journal of the Japan Veterinary Medical Association 63(7), 538-542, 2010-07-20
NAID 10026516954

Antimicrobial Susceptibility of Bordetella bronchisetica Isolates from Pigs with Respiratory Diseases on Farms in China

ZHAO Zhanqin,XUE Yun,WANG Chen,DING Ke,WU Bin,HE Qigai,CHENG Xiangchao,CHEN Huanchun
Journal of Veterinary Medical Science advpub(0), 1008120311, 2010
… One hundred and sixty-three Bordetella bronchiseptica isolates from pigs, consisting of 65 isolated in 2003 and 98 isolated in 2007, were tested for antimicrobial susceptibility to 17 antimicrobial agents by the disk diffusion method. … bronchiseptica isolates were sensitive to polymyxin B and cefoperazone/sulbactam; …
NAID 40018701690

Immune-Enhancing Effect of Fermented Maesil (Prunus mume Siebold & Zucc.) with probiotics against Bordetella bronchiseptica in Mice

JUNG Bock-Gie,KO Jae-Hyung,CHO Sun-Ju,KOH Hong-Bum,YOON So-Rah,HAN Dong-Un,LEE Bong-Joo
Journal of Veterinary Medical Science advpub(0), 1004210223, 2010
… The present study evaluated the immune enhancing effects of fermented Msesil with probiotics (Saccharomyces cerevisiae, Bacillus subtilis and Lactobacillus acidophilus) in mice, especially against Bordetella bronchiseptica, as an initial step towards the development of feed supplements for the promotion of immune activity and prevention of disease, especially in pigs. … bronchiseptica significantly increased in the mice fed fermented Maesil compared with the control group. …
NAID 130000264219

Related Pictures

★リンクテーブル★

リンク元	「ボルデテラ・ブロンキセプチカ」「気管支敗血症菌」「B. bronchiseptica」
関連記事	「bronchiseptica」

「ボルデテラ・ブロンキセプチカ」

Bordetella bronchiseptica
Classification and external resources
ICD-10	A37.8
ICD-9-CM	033.8
	[edit on Wikidata]

Bordetella bronchiseptica
	Scanning electron micrograph of B. bronchiseptica
Scientific classification
Kingdom:	Bacteria
Phylum:	Proteobacteria
Class:	Beta Proteobacteria
Order:	Burkholderiales
Family:	Alcaligenaceae
Genus:	Bordetella
Species:	B. bronchiseptica
Binomial name
	Bordetella bronchiseptica; (Ferry 1912); Moreno-López 1952

気管支敗血症菌
	B. bronchisepticaの電子顕微鏡写真
分類
学名
	Bordetella bronchiseptica; (Ferry 1912) Moreno-López 1952

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ラ: Bordetella bronchiseptica、B. bronchiseptica
関: 気管支敗血症菌

「気管支敗血症菌」

　　[★]

ラ: Bordetella bronchiseptica
関: ボルデテラ・ブロンキセプチカ

「B. bronchiseptica」

　　[★]

ボルデテラ・ブロンキセプチカ

関: Bordetella bronchiseptica

「bronchiseptica」

　　[★]

Bordetella bronchiseptica

[Sherris-1] Ryan KJ; Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed. ed.). McGraw Hill. ISBN 0-8385-8529-9.

[2] Coote JG (2001). “Environmental sensing mechanisms in Bordetella”. Adv Microb Physiol 44: 141-81. PMID 11407112.

[Barron_1996-3] Finger H, von Koenig CHW (1996). Bordetella. In: Barron's Medical Microbiology (Barron S et al, eds.) (4th ed. ed.). Univ of Texas Medical Branch. (via NCBI Bookshelf) ISBN 0-9631172-1-1.

[4] Mattoo S, Foreman-Wykert AK, Cotter PA, Miller JF (2001). “Mechanisms of Bordetella pathogenesis”. Front Biosci 6: E168-86. doi:10.2741/Mattoo. PMID 11689354.

[5] Diavatopoulos DA, Cummings CA, Schouls LM, Brinig MM, Relman DA, Mooi FR (2005). “Bordetella pertussis, the Causative Agent of Whooping Cough, Evolved from a Distinct, Human-Associated Lineage of B. bronchiseptica”. PLoS Pathog 1 (4): e45. doi:10.1371/journal.ppat.0010045. PMID 16389302.

[6] Lawhorn, Bruce. “Atrophic Rhinitis (PDF)”. Texas Agricultural Extension Service. 2006年11月23日閲覧。

[7] Wagener, J. S., R. Sobonya, L. Minnich and L. M. Taussig (1984). Role of canine parainfluenza virus and Bordetella bronchiseptica in kennel cough. Am J Vet Res 45(9): 1862-6.

[8] Burns, E. H., Jr., J. M. Norman, M. D. Hatcher and D. A. Bemis (1993). Fimbriae and determination of host species specificity of Bordetella bronchiseptica. J Clin Microbiol 31(7): 1838-44

[Mandel_1995-1] Hewlett, EL (1995). "Bordetella species." In: Principles and Practice of Infectious Diseases (Mandel, GL, Bennett, JE, Dolin, R, eds.). Churchill Livingston, Inc., New York, NY. pp. 2078–2084.

[2] Pedro-Pons, Agustín (1968). Patología y Clínica Médicas (in Spanish) 6 (3rd ed.). Barcelona: Salvat. p. 613. ISBN 84-345-1106-1.

[Sherris-3] Ryan KJ; Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. ISBN 0-8385-8529-9.

[Barron_1996-4] Finger H, von Koenig CHW (1996). Bordetella. In: Barron's Medical Microbiology (Barron S et al., eds.) (4th ed.). Univ of Texas Medical Branch. (via NCBI Bookshelf) ISBN 0-9631172-1-1.

[5] Coote JG (2001). "Environmental sensing mechanisms in Bordetella". Adv Microb Physiol 44: 141–81. doi:10.1016/S0065-2911(01)44013-6. PMID 11407112.

[6] Mattoo S, Foreman-Wykert AK, Cotter PA, Miller JF (2001). "Mechanisms of Bordetella pathogenesis". Front Biosci 6: E168–86. doi:10.2741/Mattoo. PMID 11689354.

[7] Diavatopoulos DA, Cummings CA, Schouls LM, Brinig MM, Relman DA, Mooi FR (2005). "Bordetella pertussis, the Causative Agent of Whooping Cough, Evolved from a Distinct, Human-Associated Lineage of B. bronchiseptica". PLoS Pathog 1 (4): e45. doi:10.1371/journal.ppat.0010045. PMC 1323478. PMID 16389302.

[Zoologix-8] "Bordetella data sheet". Zoologix. Retrieved 2009-03-08.

[9] Lawhorn, Bruce. "Atrophic Rhinitis" (PDF). Texas Agricultural Extension Service. Retrieved 2006-11-23. ^{[dead link]}

[10] Wagener, J. S., R. Sobonya, L. Minnich and L. M. Taussig (1984). Role of canine parainfluenza virus and Bordetella bronchiseptica in kennel cough. Am J Vet Res 45(9): 1862-6.

[11] Burns, E. H., Jr., J. M. Norman, M. D. Hatcher and D. A. Bemis (1993). Fimbriae and determination of host species specificity of Bordetella bronchiseptica. J Clin Microbiol 31(7): 1838-44

[Intervet-12] "Prevention and control of Bordetella bronchiseptica infection in cats". Intervet/Schering-Plough Animal Health. Retrieved 2009-03-08.

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Bordetella bronchiseptica