Blastomyces

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1. genus of pathogenic yeastlike fungi (同)genus Blastomyces

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/05/02 17:19:59」(JST)

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Blastomyces
Blastomyces dermatitidis
Scientific classification
Kingdom:	Fungi
Phylum:	Ascomycota
Class:	Ascomycetes
Subclass:	Incertae sedis
Order:	Incertae sedis
Family:	Incertae sedis
Genus:	Blastomyces

Blastomyces is a fungal genus responsible for the medical condition blastomycosis.

The most well known species of the genus is Blastomyces dermatitidis. B. dermatitidis is a dimorphic fungal pathogen, found primarily in the Mid-West and Northern United States and Canada. It exists in the soil in a filamentous form that produces spores directly upon the wall of the hyphae, lacking any kind of fruiting body to aid in aerosolization/dissemination of the spores. The natural reservoir of this organism in the environment is not clearly defined, but it seems to be associated with rivers and lakes. Blastomyces is endemic to the Mississippi and Ohio river valleys and the vicinity of the Great Lakes. Outbreaks of blastomycosis are often associated with disruptions of the soil that might lead to the artificial elevation of spore and/or hyphal fragments in the air. These agents infect human and animal hosts when they are inhaled. At the elevated temperature of 37°C in a host, the fungus undergoes a phase transition to the pathogenic yeast form. Yeast form cells multiply in the lung and may cause disease in immuno-competent hosts, sometimes disseminating to the skin, central nervous system and bones. Blastomycosis is more commonly diagnosed in pets than in humans, especially dogs.

References

Klein, B. S., Vergeront, J. M., Weeks, R. J. (1986) "Isolation of Blastomyces dermatitidis in soil associated with a large outbreak of blastomycosis in Wisconsin". N. Engl. J. Med. 314, 529-534.

Disalvo, A.F. (1992) "Ecology of Blastomyces dermatitidis" in: Blastomycosis (Al-Doory, Y. and Disalvo, A. F., eds), 43-73, Plenum Publishing Corp.

External links

• MeSH Blastomyces
• http://www.mycology.adelaide.edu.au/Fungal_Descriptions/Dimorphic_Pathogens/Blastomyces/
• http://pathmicro.med.sc.edu/mycology/mycology-6.htm

UpToDate Contents

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• 1. ブラストミセス症の臨床症状および診断 clinical manifestations and diagnosis of blastomycosis
• 2. ブラストミセス症の治療 treatment of blastomycosis
• 3. ブラストミセス症の菌学、病因、および疫学 mycology pathogenesis and epidemiology of blastomycosis
• 4. 血液悪性腫瘍を有する成人における侵襲性真菌感染症予防 prophylaxis of invasive fungal infections in adults with hematologic malignancies
• 5. 成人造血細胞移植レシピエントにおける侵襲性真菌感染症予防 prophylaxis of invasive fungal infections in adult hematopoietic cell transplant recipients

English Journal

• CLINICAL PROBLEM-SOLVING. On the Nose.

• Abdalla M, Sax PE, Mostaghimi A, Miller AL, Loscalzo J.
• The New England journal of medicine.N Engl J Med.2015 Sep 3;373(10):955-61. doi: 10.1056/NEJMcps1315433.
• PMID 26332551

• Blastomyces antigen detection for the diagnosis and management of blastomycosis.

• Frost HM1, Novicki TJ2.
• Journal of clinical microbiology.J Clin Microbiol.2015 Sep 2. pii: JCM.02352-15. [Epub ahead of print]
• Blastomyces spp. antigen testing was evaluated over a 10 year period in an area endemic for blastomycosis. Antigen testing was less sensitive than previously reported, but serial urine testing was useful in monitoring disease resolution or progression. Culture and cytopathology remain the gold stand
• PMID 26338856

• Fungal dimorphism: the switch from hyphae to yeast is a specialized morphogenetic adaptation allowing colonization of a host.

• Boyce KJ1, Andrianopoulos A2.
• FEMS microbiology reviews.FEMS Microbiol Rev.2015 Aug 6. pii: fuv035. [Epub ahead of print]
• The ability of pathogenic fungi to switch between a multicellular hyphal and unicellular yeast growth form is a tightly regulated process known as dimorphic switching. Dimorphic switching requires the fungus to sense and respond to the host environment and is essential for pathogenicity. This review
• PMID 26253139

Japanese Journal

• The Solution of Artificial Antimicrobial Peptides Having Potential Application to Preventing the Oral Infection in Denture Stomatitis in vitro

• LI Yin
• 日本補綴歯科学会雑誌. 特別号, 日本補綴歯科学会学術大会抄録集 = Proceedings of the ... conference, the Japan Prosthodontic Society 52(117), 279, 2008-06-06
• NAID 10024185319

• The Solution of Artificial Antimicrobial Peptides Having Potential Application to Preventing the Oral Infection in Denture Stomatitis in vitro

• YIN Li
• 日本補綴歯科学会雑誌. 特別号, 日本補綴歯科学会学術大会抄録集 = Proceedings of the ... conference, the Japan Prosthodontic Society 51(116), 272, 2007-05-18
• NAID 10024184801

Related Links

• ブラストミセス属 (Blastomyces)：抗菌薬インターネットブック

Blastomyces dermatitidis ブラストミセス・デルマチチジス 系統 抗菌薬 感受性 標準菌株 標準菌のMIC 臨床分離菌のMIC80 臨床分離菌のMIC60 備考 抗真菌剤 Amphotericin B (Liposomal) 0.125 抗真菌剤 Itraconazole 0.04 ※ ...

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★リンクテーブル★

リンク元	「ブラストミセス」「ブラストミセス属」
拡張検索	「Blastomyces dermatitidis」「Blastomyces属」

「ブラストミセス」

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Blastomyces

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ブラストミセス・デルマティティディス、ブラストミセス属、Blastomyces属

「ブラストミセス属」

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Blastomyces

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ブラストミセス、Blastomyces属

「Blastomyces dermatitidis」

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ブラストミセス・デルマティティディス

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B. dermatitidis、Blastomyces

「Blastomyces属」

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Blastomyces

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ブラストミセス、ブラストミセス属