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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/11/05 23:37:56」(JST)

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Blastocystis is a genus of single-celled protozoan parasites belonging to a group of organisms known as the Stramenopiles (also called Heterokonts) that includes algae, diatoms, and water molds. Blastocystis consists of several species, living in the gastrointestinal tracts of species as diverse as humans, farm animals, birds, rodents, reptiles, amphibians, fish, and cockroaches.^[2] Blastocystis exhibits low host specificity, and many different species of Blastocystis can infect humans^[3] and by current convention, any of these species would be identified as Blastocystis hominis.

Blastocystis is one of the most common human parasites in the world and has a global distribution.^[4]^[5]^[6]^[7] It is the most common parasitic infection in the United States, where it infected approximately 23% of the total population during year 2000.^[6]^[7] In less developed areas, infection rates as high as 100% have been observed.^[4]^[5] High rates of infection are found in individuals in developed countries who work with animals.^[5]^[8] Although the role of Blastocystis hominis in human disease is often referred to as controversial, a systematic survey of research studies conducted by 11 infectious disease specialists from nine countries, found that over 95% of papers published in the last 10 years identified it as causing illness in immunocompetent individuals.^[7] The paper attributed confusion over pathogenicity to the existence of asymptomatic carriers, a phenomenon the study noted is common to all gastrointestinal protozoa.^[7]

Classification

The appropriate classification of Blastocystis has only recently been resolved. The original description of Blastocystis was as a yeast due to its yeast-like glistening appearance in fresh wet mounts and the absence of pseudopodia and locomotion.^[9] This was then contradicted by Zierdt,^[10] who reclassified it under subphylum Sporozoa (and later in Sarcodina), based on some distinctive protistan features of the Blastocystis cell, such as the presence of nuclei, smooth and rough endoplasmic reticulum, Golgi complex, and mitochondrion-like organelles. Its sensitivity to antiprotozoal drugs and its inability to grow on fungal media further indicated that it was a protozoan.

However, major revisions were made to its classification. An analysis of gene sequences was performed in 1996, which placed it into the group Stramenopiles.^[11]^[12] Other Stramenopiles include brown algae, mildew, diatoms, the organism that caused the Irish potato famine, and the organism responsible for Sudden oak death disease. However, the position of Blastocystis within the stramenopiles remains enigmatic.^[13]

Signs and symptoms

Most published studies have reported that between 50% and 80% of individuals mono-infected with Blastocystis will show symptoms.^[14]^[15] Factors influencing presentation of symptoms have been listed as the patient's age, with younger patients less likely to show symptoms, as well genetic changes that influence the production of cytokines.^[16] Some studies have suggested that pathogenicity may be linked to specific subtypes of Blastocystis^[17] and experimental infection of animals has reported varying degrees of illness depending on the subtype used.^[18] While some subtypes appear to be less likely to result in symptomatic infection, those subtypes are also found in symptomatic individuals who have no other infection found.^[16] Symptoms associated with the infection are diarrhea,constipation, nausea, abdominal cramps, bloating, excessive gas, and anal itching.^[19] Most cases of the infection appear to become diagnosed as irritable bowel syndrome, according to studies from Denmark,^[20] Pakistan, the United Kingdom, and Italy.^[7] The timescale of infection with the parasite can range from weeks to years.^[21] In the early 2000s, Egyptian physicians identified 84 patients with diarrhea and enteritis apparently caused by Blastocystis hominis. After three days of nitazoxanide treatment, symptoms cleared and no fecal organisms were detectable in 36 (86%) of 42 treated patients and in 16 (38%) of 42 people who received placebo (P < .0001). the investigators concluded that either B hominis is pathogenic and can often be effectively treated with nitazoxanide, or that nitazoxanide (a drug approved by the FDA for the treatment of giardia and cryptosporidia) eradicated an unidentifiable organism.^[22]

Taxonomy

For many years, scientists believed one species of Blastocystis infected humans, while different species of Blastocystis infected other animals. So they called Blastocystis from humans Blastocystis hominis and gave different species names to Blastocystis from other animals, for example Blastocystis ratti from rats. In recent years, various genetic analysis have shown that Blastocystis hominis as a unique entity does not exist, i.e. there is no single species of Blastocystis that infects humans.^[3]

In fact, a number of distinct genetic types of Blastocystis can infect humans, including those previously called Blastocystis ratti^[23] and the differences are so great that they could be considered separate species. Because of this, in 2007 scientists proposed discontinuing the use of the term Blastocystis hominis. Their proposal was to refer to Blastocystis from humans and animals as Blastocystis sp. subtype nn where nn is a number assigned to each group according to the degree of genetic identity of the Blastocystis organisms, based on gene sequences, rather than the host that was infected.^[24] At that time nine subtypes were known to infect mammals and birds, all of which had been found in humans.

A tenth group was reported in China in 2007,^[25] but a full analysis of its relationships has not yet been performed and it is not yet clear whether it is a group within a described subtype or a new subtype. A definite tenth subtype was then found in a variety of other mammals, including primates, but it has not as yet been found in humans.^[26]

There are now at least 13 genetically distinct small subunit ribosomal RNA lineages.^[27] These additional subtypes were found in a variety of mammalian hosts (including elephants and giraffes) and it is very likely that more subtypes will be found as more hosts are surveyed.

Epidemiology

Blastocystis spp. prevalence in humans often exceeds 5% in industrialized countries.^[28] In the United States, it infected approximately 23% of the total population during year 2000.^[6]^[7] In less developed areas, infection rates with one or more subtypes are as high as 100%.^[4]^[5]

Transmission

Fecal-oral transmission is the most accepted pathway, and recent studies have shown that transmission involves only the cyst form of the parasite.^[29] The extent to which human-human, human-animal, and animal-human transmission occurs is still unknown. Genomic studies provide evidence for all three routes, though experimental studies have yet to provide conclusive proof for the existence of either.^[30]

Reservoir

Conclusively stating that Blastocystis has an animal reservoir depends upon unraveling the true nature of its transmission. If, as Noël et al. deem likely based upon their own molecular work and a review of the literature, animal-to-human transmission is possible, then animals such as pigs and dogs could in fact be acting as a large reservoir capable of human infection.^[31] Epidemiological studies finding that infection is more common in people living in proximity to farm animals or pets^[21] further supports this notion.

Morphology

Blastocystis has various morphological forms.

Four commonly described forms are the vacuolar (otherwise known as central body), granular, amoeboid, and cyst forms. The appearance of the organism is largely dependent upon environmental conditions as it is extremely sensitive to oxygen. Whether all of these forms exist in the host intestine is unclear.

Vacuolar form

The vacuolar form is the typical cell form of Blastocystis seen in culture and is often used for the identification of the organism. These vacuolar forms vary greatly in size, with diameters ranging between 2 µm and 200 µm. The vacuolar form is otherwise known as central body form because it has a large central vacuole surrounded by a thin band of peripheral cytoplasm which contains other organelles. Flocculent material has been described as being scattered unevenly throughout the vacuole. The function of the vacuole is still unclear, however, it has been suggested that, like for many eukaryotic cells, it is for storage purposes. Other functions, such as cell division during reproduction and the deposition of apoptotic bodies, have been proposed, although more tests need to be done to validate these roles.

Four common forms of Blastocystis hominis. Clockwise from top left: vacuolar, granular, amoeboid, and cyst forms.

Granular form

The granular form is somewhat morphologically similar to the vacuolar forms except that distinct granules are observed in the central vacuole and / or cytoplasm. Within the central vacuole, these granules appear in different forms too. Three types were suggested – metabolic, lipid, and reproductive granules. Metabolic granules play a role in chemical processes that are necessary for the maintenance of life in the organism. It was also put forward that reproductive granules were involved in the development of progeny cells. These hypotheses were made based on microscopy alone, which may be deemed misleading, hence more need to be done before making a definite conclusion. It has also been suggested that the granules may be an indication that the cell is dying.

Amoeboid form

The other form that exists is the amoeboid form. The amoeboid form of Blastocystis is non-motile and strongly adhesive. A research study has reported that amoeboid forms are produced only in cultures taken from symptomatic individuals, with asymptomatic individuals producing exclusively vacuolar forms. The study suggested this method could be used for diagnosing symptomatic infection. Additionally, it suggested the symptoms could be due to the accumulation of the strongly adhesive amoeboid forms on the host's intestinal wall. A detailed ultra-structural study of amoeboid forms was published in 2007.^[32]

Cyst form

The Blastocystis cyst form is a more recent discovery and has helped in the advancement of understanding the way the infection is transmitted. As compared to the other forms, it is generally smaller in size and has a thick multilayered cyst wall. It lacks a central vacuole and few nuclei, multiple vacuoles and food storage deposits were observed. The cyst form is the most resistant form of this parasite and is able to survive in harsh conditions because of its thick multilayered cyst wall. Experiments have been carried out to show its ability to withstand acidic gastric juices. Besides, the cysts did not lyse when placed in distilled water and could survive well at room temperature for up to 19 days, indicating its strong resistance.^[33]^[34]

Life cycle

The supposed life cycle begins with ingestion of the cyst form. After ingestion, the cyst develops into other forms which may in turn re-develop into cyst forms. Through human feces, the cyst forms enter the external environment and are transmitted to humans and other animals via the fecal–oral route, repeating the entire cycle.

Life cycle of Blastocystis proposed by Tan^[35]

Obtaining and culturing Blastocystis

The ATCC maintains a collection of Blastocystis isolates. Some records show whether the isolates were obtained from symptomatic or asymptomatic carriers. As yet, no publication has identified the subtypes of most of the ATCC isolates, which are mostly axenic. Researchers have reported that patients with Irritable bowel syndrome may provide a reliable source for xenic Blastocystis isolates. Some researchers have reported being able to culture Blastocystis from 46% of IBS patients.^[36] Researchers have described different culture mechanisms for growing Blastocystis. Colony growth on solid medium colonies on solid culture medium using a synthetic medium with added supplements have both been described.^[37]^[38] However, most cultivation is performed in liquid media of various types.

References

^ Alexeieff A (1911). "Sur la nature des formations dites "kystes de Trichomonas intestinalis"". CR Soc Biol. 71: 296–298.
^ Yoshikawa H, Wu Z, Howe J, Hashimoto T, Geok-Choo N, Tan KS (2007). "Ultrastructural and phylogenetic studies on Blastocystis isolates from cockroaches". The Journal of Eukaryotic Microbiology. 54 (1): 33–7. doi:10.1111/j.1550-7408.2006.00141.x. PMID 17300516.
^ ^a ^b Noël C, Dufernez F, Gerbod D, et al. (January 2005). "Molecular Phylogenies of Blastocystis Isolates from Different Hosts: Implications for Genetic Diversity, Identification of Species, and Zoonosis". Journal of Clinical Microbiology (in Chinese). 43 (1): 348–55. doi:10.1128/JCM.43.1.348-355.2005. PMC 540115. PMID 15634993.
^ ^a ^b ^c El Safadi D, Gaayeb L, Meloni D, Cian A, Poirier P, Wawrzyniak I, Delbac F, Dabboussi F, Delhaes L, Seck M, Hamze M, Riveau G, Viscogliosi E (March 2014). "Children of Senegal River Basin show the highest prevalence of Blastocystis sp. ever observed worldwide". BMC Infect. Dis. 14: 164. doi:10.1186/1471-2334-14-164. PMC 3987649. PMID 24666632.
^ ^a ^b ^c ^d Roberts T, Stark D, Harkness J, Ellis J (May 2014). "Update on the pathogenic potential and treatment options for Blastocystis sp". Gut Pathog. 6: 17. doi:10.1186/1757-4749-6-17. PMC 4039988. PMID 24883113. Blastocystis is one of the most common intestinal protists of humans. ... A recent study showed that 100% of people from low socio-economic villages in Senegal were infected with Blastocystis sp. suggesting that transmission was increased due to poor hygiene sanitation, close contact with domestic animals and livestock, and water supply directly from well and river [10]. ...
Table 2: Summary of treatments and efficacy for Blastocystis infection
^ ^a ^b ^c Amin OM (2002). "Seasonal prevalence of intestinal parasites in the United States during 2000" (PDF). Am. J. Trop. Med. Hyg. 66 (6): 799–803. PMID 12224595. Retrieved 3 January 2016. Parasitologic investigations of large patient populations are rarely conducted in the United States, where the illusion of freedom from parasitic infections still predominates. Such investigations are considerably more common in third-world countries where endemic parasitoses are more readily documented.¹ In an attempt to address this problem we reported the results of routine examination of fecal specimens for parasites from 644 patients in the United States during the summer of 1996. ...
Prevalence. Nine hundred sixteen (32%) of 2,896 tested patients were infected with 18 species of intestinal parasites in the year 2000 (Table 1) in 48 states and the District of Columbia as follows ... Blastocystis hominis was the most frequently detected parasite in single and multiple infections, with Cryptosporidium parvum and Entamoeba histolytica/E. dispar ranking second and third, respectively.
^ ^a ^b ^c ^d ^e ^f Boorom KF, Smith H, Nimri L, Viscogliosi E, Spanakos G, Parkar U, Li LH, Zhou XN, Ok UZ, Leelayoova S, Jones MS (2008). "Oh my aching gut: irritable bowel syndrome, Blastocystis, and asymptomatic infection". Parasit Vectors. 1 (1): 40. doi:10.1186/1756-3305-1-40. PMC 2627840. PMID 18937874. Blastocystis is now by far the most prevalent mono-infection in symptomatic patients in the United States [14] and was found 28.5 times more often than Giardia lamblia as a mono-infection in symptomatic patients in a 2000 study [14].
Figure 4: Prevalence of IBS and Blastocystosis by country
^ Parkar U, Traub RJ, Vitali S, et al. (April 2010). "Molecular characterization of Blastocystis isolates from zoo animals and their animal-keepers". Vet. Parasitol. 169 (1–2): 8–17. doi:10.1016/j.vetpar.2009.12.032. PMID 20089360.
^ Brumpt E (1912). "Blastocystis hominis n. sp. et formes voisines". Bulletin of the Exotic Pathology Society. 5: 725–30.
^ Perez-Cordon, G. et al. Finding of Blastocystis sp. in bivalves of the genus Donax. Rev. peru biol. 2007, vol. 14, n.2, pp. 301-302.
^ Stechmann A, Hamblin K, Pérez-Brocal V, et al. (April 2008). "Organelles in Blastocystis that Blur the Distinction between Mitochondria and Hydrogenosomes". Current Biology. 18 (8): 580–5. doi:10.1016/j.cub.2008.03.037. PMC 2428068. PMID 18403202.
^ Silberman JD, Sogin ML, Leipe DD, Clark CG (1996). "Human parasite finds taxonomic home". Nature. 380 (6573): 398. doi:10.1038/380398a0. PMID 8602239.
^ Baldauf, Sandra L. (2008). "An overview of the phylogeny and diversity of eukaryotes" (PDF). Journal of Systematics and Evolution. 46 (3): 263–73. doi:10.3724/SP.J.1002.2008.08060.
^ Yoshikawa H, Wu Z, Kimata I, et al. (January 2004). "Polymerase chain reaction-based genotype classification among human Blastocystis hominis populations isolated from different countries". Parasitol. Res. 92 (1): 22–9. doi:10.1007/s00436-003-0995-2. PMID 14598169.
^ _Amin OM (June 2002). "Seasonal prevalence of intestinal parasites in the United States during 2000". Am. J. Trop. Med. Hyg. 66 (6): 799–803. PMID 12224595.
^ ^a ^b Dogruman-Al F, Kustimur S, Yoshikawa H, et al. (August 2009). "Blastocystis subtypes in irritable bowel syndrome and inflammatory bowel disease in Ankara, Turkey". Mem. Inst. Oswaldo Cruz. 104 (5): 724–7. doi:10.1590/S0074-02762009000500011. PMID 19820833.
^ Tan TC, Suresh KG (February 2006). "Predominance of amoeboid forms of Blastocystis hominis in isolates from symptomatic patients". Parasitol. Res. 98 (3): 189–93. doi:10.1007/s00436-005-0033-7. PMID 16323025.
^ Hussein EM, Hussein AM, Eida MM, Atwa MM (April 2008). "Pathophysiological variability of different genotypes of human Blastocystis hominis Egyptian isolates in experimentally infected rats". Parasitol. Res. 102 (5): 853–60. doi:10.1007/s00436-007-0833-z. PMID 18193282.
^ "Division of Parasitic Diseases - Blastocystis hominis Infection Fact Sheet". Cdc.gov. 2008-06-06. Retrieved 2010-04-04.
^ Stensvold CR, Lewis HC, Hammerum AM, et al. (November 2009). "Blastocystis: unravelling potential risk factors and clinical significance of a common but neglected parasite". Epidemiol. Infect. 137 (11): 1655–63. doi:10.1017/S0950268809002672. PMID 19393117.
^ ^a ^b Doyle PW, Helgason MM, Mathias RG, Proctor EM (January 1990). "Epidemiology and pathogenicity of Blastocystis hominis". Journal of Clinical Microbiology. 28 (1): 116–21. PMC 269548. PMID 2298869.
^ Rossignol JF, Kabil SM, Said M, Samir H, Younis AM (2005). "Effect of nitazoxanide in persistent diarrhea and enteritis associated with Blastocystis hominis". Clin. Gastroenterol. Hepatol. 3 (10): 987–91. doi:10.1016/S1542-3565(05)00427-1. PMID 16234044.
^ Puthia MK, Sio SW, Lu J, Tan KS (July 2006). "Blastocystis ratti Induces Contact-Independent Apoptosis, F-Actin Rearrangement, and Barrier Function Disruption in IEC-6 Cells". Infection and Immunity. 74 (7): 4114–23. doi:10.1128/IAI.00328-06. PMC 1489721. PMID 16790785.
^ Stensvold CR, Suresh GK, Tan KS, et al. (March 2007). "Terminology for Blastocystis subtypes--a consensus". Trends in Parasitology. 23 (3): 93–6. doi:10.1016/j.pt.2007.01.004. PMID 17241816.
^ Li LH, Zhang XP, Lv S, et al. (December 2007). "Cross-sectional surveys and subtype classification of human Blastocystis isolates from four epidemiological settings in China". Parasitology Research. 102 (1): 83–90. doi:10.1007/s00436-007-0727-0. PMID 17912552.
^ Stensvold CR, Alfellani MA, Nørskov-Lauritsen S, et al. (March 2009). "Subtype distribution of Blastocystis isolates from synanthropic and zoo animals and identification of a new subtype". International Journal for Parasitology. 39 (4): 473–9. doi:10.1016/j.ijpara.2008.07.006. PMID 18755193.
^ Parkar U, Traub RJ, Vitali S, et al. (2010). "Molecular characterization of Blastocystis isolates from zoo animals and their animal-keepers.". Veterinary Parasitology. 169 (1-2): 8–17. doi:10.1016/j.vetpar.2009.12.032. PMID 20089360.
^ Tan KS (2008) New insights on classification, identification, and clinical relevance of Blastocystis spp. Clin Microbiol Rev 21: 639–665
^ Yoshikawa H, Yoshida K, Nakajima A, Yamanari K, Iwatani S, Kimata I (December 2004). "Fecal-oral transmission of the cyst form of Blastocystis hominis in rats". Parasitology Research. 94 (6): 391–6. doi:10.1007/s00436-004-1230-5. PMID 15480786.
^ Yoshikawa H, Abe N, Iwasawa M, et al. (April 2000). "Genomic Analysis of Blastocystis hominis Strains Isolated from Two Long-Term Health Care Facilities". Journal of Clinical Microbiology. 38 (4): 1324–30. PMC 86440. PMID 10747102.
^ Noël C, Peyronnet C, Gerbod D, et al. (January 2003). "Phylogenetic analysis of Blastocystis isolates from different hosts based on the comparison of small-subunit rRNA gene sequences". Molecular and Biochemical Parasitology. 126 (1): 119–23. doi:10.1016/S0166-6851(02)00246-3. PMID 12554093.
^ Tan TC, Suresh KG (November 2006). "Amoeboid form of Blastocystis hominis - a detailed ultrastructural insight". Parasitology Research. 99 (6): 737–42. doi:10.1007/s00436-006-0214-z. PMID 16816959.
^ Zaman V, Howe J, Ng M (1995). "Ultrastructure of Blastocystis hominis cysts". Parasitology Research. 81 (6): 465–9. doi:10.1007/BF00931787. PMID 7567903.
^ Moe KT, Singh M, Howe J, et al. (1996). "Observations on the ultrastructure and viability of the cystic stage of Blastocystis hominis from human feces". Parasitology Research. 82 (5): 439–44. doi:10.1007/s004360050142. PMID 8738284.
^ Tan KS (December 2004). "Blastocystis in humans and animals: new insights using modern methodologies". Veterinary Parasitology. 126 (1–2): 121–44. doi:10.1016/j.vetpar.2004.09.017. PMID 15567582.
^ Yakoob J, Jafri W, Jafri N, et al. (April 2004). "Irritable bowel syndrome: in search of an etiology: role of Blastocystis hominis". The American Journal of Tropical Medicine and Hygiene. 70 (4): 383–5. PMID 15100450.
^ Tan SW, Singh M, Yap EH, et al. (1996). "Colony formation of Blastocystis hominis in soft agar". Parasitology Research. 82 (4): 375–7. doi:10.1007/s004360050130. PMID 8740557.
^ Tan SW, Singh M, Thong KT, et al. (1996). "Clonal growth of Blastocystis hominis in soft agar with sodium thioglycollate". Parasitology Research. 82 (8): 737–9. doi:10.1007/s004360050194. PMID 8897510.

External links

CDC description of Blastocystis hominis
Blastocystis Research Foundation
Dientamoeba Fragilis and Blastocystis Hominis
Blastocystis Blog by CR Stensvold

UpToDate Contents

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1. ブラストシスチス種 blastocystis species
2. 先進国の成人における慢性下痢に対するアプローチ approach to the adult with chronic diarrhea in developed countries
3. メトロニダゾール：概要 metronidazole an overview
4. 非病原性腸内原虫 nonpathogenic enteric protozoa
5. 開発途上国の小児における持続性下痢 persistent diarrhea in children in developing countries

English Journal

The prevalence of intestinal parasites in hemodialysis patients in Bushehr, Iran.

Barazesh A1, Fouladvand M, Tahmasebi R, Heydari A, Fallahi J.
Hemodialysis international. International Symposium on Home Hemodialysis.Hemodial Int.2015 Feb 3. doi: 10.1111/hdi.12272. [Epub ahead of print]
Hemodialysis patients, due to a dysfunction of the immune response, are prone to a variety of opportunistic infections. Studies of intestinal parasitic infections in these patients are limited. Therefore, the present study was performed to determine the prevalence of these infections in patients on
PMID 25643728

Seropositivity for ascariosis and toxocariosis and cytokine expression among the indigenous people in the venezuelan delta region.

Araujo Z1, Brandes S2, Pinelli E2, A Bochichio M1, Palacios A1, Wide A3, Rivas-Santiago B4, Jiménez JC5.
Revista do Instituto de Medicina Tropical de São Paulo.Rev Inst Med Trop Sao Paulo.2015 Feb;57(1):47-55. doi: 10.1590/S0036-46652015000100007.
The present study aimed at measuring seropositivities for infection by Ascaris suum and Toxocara canis using the excretory/secretory (E/S) antigens from Ascaris suum (AES) and Toxocara canis (TES) within an indigenous population. In addition, quantification of cytokine expressions in peripheral bloo
PMID 25651326

Japanese Journal

Infectivity of different genotypes of human Blastocystis hominis isolates in chickens and rats

IGUCHI Aya,EBISU Akiko,NAGATA Satiko,SAITOU Yumie,YOSHIKAWA Hisao,IWATANI Satoru,KIMATA Isao
Parasitology international : official journal of the Japanese Society of Parasitology 57(2), 107-112, 2008-06-01
NAID 10020150538

Infectivity of different genotypes of human Blastocystis hominis isolates in chickens and rats

IGUCHI Aya,EBISU Akiko,NAGATA Satiko,SAITOU Yumie,YOSHIKAWA Hisao,IWATANI Satoru,KIMATA Isao
Parasitology international : official journal of the Japanese Society of Parasitology 56(2), 107-112, 2007-06-01
NAID 10027668356

Related Pictures

★リンクテーブル★

リンク元	「ヒトブラストシスチス」「ブラストシスチス・ホミニス」
関連記事	「Blastocystis」「hominis」

「ヒトブラストシスチス」

Blastocystis
	Blastocystis sp.
Scientific classification
Domain:	Eukaryota
(unranked):	SAR
Superphylum:	Heterokonta
Class:	Blastocystae
Order:	Blastocystida
Family:	Blastocystidae
Genus:	Blastocystis; (Alexieff 1911) Brumpt 1912

　　[★]

ラ: Blastocystis hominis
関: ブラストシスチス・ホミニス

「ブラストシスチス・ホミニス」

　　[★]

ラ: Blastocystis hominis
関: ヒトブラストシスチス

「Blastocystis」

　　[★]

ブラストシスチス、ラストシスチス属、Blastocystis属

関: Blastocystina

「hominis」

　　[★]

Mycoplasma hominis、Blastocystis hominis

[1] Alexeieff A (1911). "Sur la nature des formations dites "kystes de Trichomonas intestinalis"". CR Soc Biol. 71: 296–298.

[YOSHIKAWA_2007-2] Yoshikawa H, Wu Z, Howe J, Hashimoto T, Geok-Choo N, Tan KS (2007). "Ultrastructural and phylogenetic studies on Blastocystis isolates from cockroaches". The Journal of Eukaryotic Microbiology. 54 (1): 33–7. doi:10.1111/j.1550-7408.2006.00141.x. PMID 17300516.

[NOEL_2005-3] Noël C, Dufernez F, Gerbod D, et al. (January 2005). "Molecular Phylogenies of Blastocystis Isolates from Different Hosts: Implications for Genetic Diversity, Identification of Species, and Zoonosis". Journal of Clinical Microbiology (in Chinese). 43 (1): 348–55. doi:10.1128/JCM.43.1.348-355.2005. PMC 540115. PMID 15634993.

[Primary:_Blastocystosis_100.25_prevalence-4] El Safadi D, Gaayeb L, Meloni D, Cian A, Poirier P, Wawrzyniak I, Delbac F, Dabboussi F, Delhaes L, Seck M, Hamze M, Riveau G, Viscogliosi E (March 2014). "Children of Senegal River Basin show the highest prevalence of Blastocystis sp. ever observed worldwide". BMC Infect. Dis. 14: 164. doi:10.1186/1471-2334-14-164. PMC 3987649. PMID 24666632.

[Efficacy_against_Blastocystis-5] Roberts T, Stark D, Harkness J, Ellis J (May 2014). "Update on the pathogenic potential and treatment options for Blastocystis sp". Gut Pathog. 6: 17. doi:10.1186/1757-4749-6-17. PMC 4039988. PMID 24883113. Blastocystis is one of the most common intestinal protists of humans. ... A recent study showed that 100% of people from low socio-economic villages in Senegal were infected with Blastocystis sp. suggesting that transmission was increased due to poor hygiene sanitation, close contact with domestic animals and livestock, and water supply directly from well and river [10]. ...
Table 2: Summary of treatments and efficacy for Blastocystis infection

[Parasites_in_representative_sample_of_US_population-6] Amin OM (2002). "Seasonal prevalence of intestinal parasites in the United States during 2000" (PDF). Am. J. Trop. Med. Hyg. 66 (6): 799–803. PMID 12224595. Retrieved 3 January 2016. Parasitologic investigations of large patient populations are rarely conducted in the United States, where the illusion of freedom from parasitic infections still predominates. Such investigations are considerably more common in third-world countries where endemic parasitoses are more readily documented.¹ In an attempt to address this problem we reported the results of routine examination of fecal specimens for parasites from 644 patients in the United States during the summer of 1996. ...
Prevalence. Nine hundred sixteen (32%) of 2,896 tested patients were infected with 18 species of intestinal parasites in the year 2000 (Table 1) in 48 states and the District of Columbia as follows ... Blastocystis hominis was the most frequently detected parasite in single and multiple infections, with Cryptosporidium parvum and Entamoeba histolytica/E. dispar ranking second and third, respectively.

[Blastocystosis_prevalence-7] ^ ^a ^b ^c ^d ^e ^f Boorom KF, Smith H, Nimri L, Viscogliosi E, Spanakos G, Parkar U, Li LH, Zhou XN, Ok UZ, Leelayoova S, Jones MS (2008). "Oh my aching gut: irritable bowel syndrome, Blastocystis, and asymptomatic infection". Parasit Vectors. 1 (1): 40. doi:10.1186/1756-3305-1-40. PMC 2627840. PMID 18937874. Blastocystis is now by far the most prevalent mono-infection in symptomatic patients in the United States [14] and was found 28.5 times more often than Giardia lamblia as a mono-infection in symptomatic patients in a 2000 study [14].
Figure 4: Prevalence of IBS and Blastocystosis by country

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Blastocystis hominis