Arias-Stella reaction, also Arias-Stella phenomenon, is a benign change in the endometrium associated with the presence of chorionic tissue.[1]
Arias-Stella reaction is due to progesterone primarily.
Cytologically, it looks like a malignancy and, historically, it was diagnosed as endometrial cancer.[1]
Contents
1Significance
2Diagnosis
3History
4See also
5References
Significance
It is significant only because it can be misdiagnosed as a cancer. It may be seen in a completely normal pregnancy.
Diagnosis
It is characterized by nuclear enlargement and may also have any of the following: an irregular nuclear membrane, granular chromatin, centronuclear vacuolization, and pseudonuclear inclusions.[1]
Five subtypes are recognized:[1]
Minimal atypia.
Early secretory pattern.
Secretory or hypersecretory pattern.
Regenerative, proliferative or nonsecretory pattern.
Monstrous cell pattern.
History
It was first described by Javier Arias Stella, a Peruvian pathologist in 1954.[2]
See also
Choriocarcinoma
Chorioangioma
Herpes
Nuclear atypia
Nuclear pleomorphism
References
^ abcdArias-Stella, J. (Jan 2002). "The Arias-Stella reaction: facts and fancies four decades after". Adv Anat Pathol. 9 (1): 12–23. doi:10.1097/00125480-200201000-00003. PMID 11756756.
^Arias-Stella, J. (Aug 1954). "Atypical endometrial changes associated with the presence of chorionic tissue". Arch Pathol. 58 (2): 112–28. PMID 13170908.
Bibliography
Textbook of Obstetrics by D.C. Dutta Page no. 180. ISBN 81-7381-142-3
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… possible to minimize the impact of the reaction. This topic describes our approach to determining the nature of a suspected acute reaction (ie, the type of reaction and likely causes) following transfusion …
…after two weeks of treatment. If the reaction has not improved or has worsened, patients are treated in the same way as those with grade 3 rash . For grade 2 reaction that does not respond to treatment …
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English Journal
Use of Immunohistochemical Markers (HNF-1β, Napsin A, ER, CTH, and ASS1) to Distinguish Endometrial Clear Cell Carcinoma From Its Morphologic Mimics Including Arias-Stella Reaction.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 2019 May;().
The diagnosis of clear cell (CC) carcinoma of the endometrium can be challenging, especially when endometrioid (EC) and serous (SC) endometrial cancers exhibit nonspecific clear cell changes, in carcinomas with mixed histology and in the setting of Arias-Stella reaction (ASR). In this study, classic
Napsin A, Hepatocyte Nuclear Factor-1-Beta (HNF-1β), Estrogen and Progesterone Receptors Expression in Arias-Stella Reaction.
Ip PPC, Wang SY, Wong OGW, Chow KL, Lee HH, Cheung ANY, Tse KY.
The American journal of surgical pathology. 2019 Mar;43(3)325-333.
The Arias-Stella reaction (ASR) can mimic endometrial clear cell carcinoma (ECCC) in small biopsies, especially when drug or pregnancy history is unknown. A panel of immunohistochemical markers comprising napsin A, hepatocyte nuclear factor-1-beta (HNF-1β), estrogen and progesterone receptors (ER,
Benign endometrial proliferations mimicking malignancies: a review of problematic entities in small biopsy specimens.
, I I, P P, P P, .
Virchows Archiv : an international journal of pathology. 2018 Jun;472(6)907-917.
Benign proliferations that mimic malignancies are commonly encountered during the course of assessment of small and fragmented endometrial samples. Although benign, endometrial epithelial metaplasias often coexist with premalignant or malignant lesions causing diagnostic confusion. The difficulty wi
Pseudoneoplastic glandular response of the female genital tract, first described by Javier Arias-Stella in 1954 as atypical endometrial changes associated with the presence of chorionic tissue Characterized by enlarged glands with ...
Conclusions: Recognition of Arias-Stella reaction in extra-uterine sites, especially in young women, is critical to avoid misdiagnosis of this innocuous lesion as clear cell adenocarcinoma. Attention to cellular and nuclear ...
General Benign atypical endometrial changes associated with chorionic tissue. May be seen in a normal pregnancy, hydatidiform moles, others. Historically it was diagnosed as endometrial cancer. Usually in premenopausal women - pregnant ...