WordNet
- (genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
- informal term for information; "give me the gen on your new line of computers"
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- 1. 慢性粘膜皮膚カンジダ症 chronic mucocutaneous candidiasis
- 2. 自己免疫の概要 overview of autoimmunity
- 3. 原発性副腎不全（アジソン病）の原因 causes of primary adrenal insufficiency addisons disease
- 4. 副甲状腺機能低下症 hypoparathyroidism
- 5. 1型糖尿病の病因 pathogenesis of type 1 diabetes mellitus
English Journal
- Extensive RNA editing and splicing increase immune self-representation diversity in medullary thymic epithelial cells.
- Danan-Gotthold M1, Guyon C2, Giraud M2, Levanon EY3, Abramson J4.
- Genome biology.Genome Biol.2016 Oct 24;17(1):219.
- BACKGROUND: In order to become functionally competent but harmless mediators of the immune system, T cells undergo a strict educational program in the thymus, where they learn to discriminate between self and non-self. This educational program is, to a large extent, mediated by medullary thymic epit
- PMID 27776542
- Expression And Prognostic Significance Of The Autoimmune Regulator Gene In Breast Cancer Cells.
- Bianchi F1,2, Sommariva M1,2, De Cecco L3, Triulzi T2, Romero-Cordoba S4, Tagliabue E2, Sfondrini L1, Balsari A1,2.
- Cell cycle (Georgetown, Tex.).Cell Cycle.2016 Oct 18:0. [Epub ahead of print]
- The autoimmune regulator gene (AIRE) plays a fundamental role in tolerance by promoting the expression of tissue-specific antigens in medullary thymic epithelial cells (mTECs). Recently, AIRE expression was detected also in human keratinocytes and in tumors originating in stratified epithelia. Here,
- PMID 27753538
- The dual role of autoimmune regulator in maintaining normal expression level of tissue-restricted autoantigen in the thymus: A modeling investigation.
- Mitre TM1, Khadra A2, Pietropaolo M3.
- Mathematical biosciences.Math Biosci.2016 Oct 17. pii: S0025-5564(16)30241-3. doi: 10.1016/j.mbs.2016.10.002. [Epub ahead of print]
- The expression level of tissue-restricted autoantigens (TSA) in the thymus is crucial for the negative selection of autoreactive T cells during central tolerance. The autoimmune regulator factor (AIRE) plays an important role in the positive regulation of these TSA in medullary thymic epithelial cel
- PMID 27765528
Related Links
- Summary. This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus.
- AIRE (Autoimmune Regulator) is a Protein Coding gene. Diseases associated with AIRE include Autoimmune Polyendocrine Syndrome, Type I, With Or Without Reversible Metaphyseal Dysplasia and Autoimmune Polyendocrine Syndrome Type 1 . Gene Ontology (GO) annotations related to this gene include identical protein binding and transcription cis ...
- The AIRE gene provides instructions for making a protein called the autoimmune regulator. This protein is active primarily in the thymus, which is an organ located behind the breastbone that plays an important role in immune system function. The thymus prepares immune cells called T cells for their role in fighting infection; this process is ...
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- 5-aminoimidazole ribotide