WordNet

(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
informal term for information; "give me the gen on your new line of computers"

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1. 慢性粘膜皮膚カンジダ症 chronic mucocutaneous candidiasis
2. 原発性副腎不全（アジソン病）の原因 causes of primary adrenal insufficiency addisons disease
3. 幼児および小児における低カルシウム血症の病因 etiology of hypocalcemia in infants and children
4. T細胞陰性、B細胞陰性、NK細胞陽性の重度複合型免疫不全 t cell negative b cell negative nk cell positive severe combined immunodeficiency
5. 小児における慢性下痢の原因の概要 overview of the causes of chronic diarrhea in children

Association of rs2075876 polymorphism of AIRE gene with rheumatoid arthritis risk.

Feng ZJ1, Zhang SL2, Wen HF3, Liang Y4.
Human immunology.Hum Immunol.2015 Jan 29. pii: S0198-8859(15)00027-0. doi: 10.1016/j.humimm.2015.01.026. [Epub ahead of print]
BACKGROUND: Autoimmune regulator (AIRE), a protein encoded by AIRE gene, is a transcriptional factor primarily expressed in medullary thymic epithelial cells (mTECs). It has pivotal role in regulation of human immunology. The mutations of AIRE gene or protein level changes would alter the status of
PMID 25637666

Roncalés-Samanes P1, de Arriba Muñoz A2, Lou Francés GM2, Ferrer Lozano M2, Justa Roldán ML3, Labarta Aizpun JI2.
Anales de pediatría (Barcelona, Spain : 2003).An Pediatr (Barc).2015 Jan;82(1):e60-3. doi: 10.1016/j.anpedi.2014.01.012. Epub 2014 Feb 26.
Polyglandular autoimmune syndromes are rare diseases based on autoimmune mechanisms in which endocrine and non-endocrine disorders coexist. In type 1 the characteristic manifestations are chronic mucocutaneous candidiasis, hypoparathyroidism and adrenal insufficiency. A case is presented of a patien
PMID 24582129

Aire-dependent peripheral tissue antigen mRNAs in mTEC cells feature networking refractoriness to microRNA interaction.

Macedo C1, Oliveira EH1, Almeida RS1, Donate PB1, Fornari TA1, Pezzi N1, Sakamoto-Hojo ET2, Donadi EA3, Passos GA4.
Immunobiology.Immunobiology.2015 Jan;220(1):93-102. doi: 10.1016/j.imbio.2014.08.015. Epub 2014 Aug 27.
The downregulation of PTA genes in mTECs is associated with the loss of self-tolerance, and the role of miRNAs in this process is not fully understood. Therefore, we studied the expression of mRNAs and miRNAs in mTECs from autoimmune NOD mice during the period when loss of self-tolerance occurs in p
PMID 25220732