English Journal
- Identification and characterization of novel human glucose-6-phosphate dehydrogenase inhibitors.
- Preuss J, Richardson AD, Pinkerton A, Hedrick M, Sergienko E, Rahlfs S, Becker K, Bode L.Source1University of California, San Diego, CA, USA.
- Journal of biomolecular screening.J Biomol Screen.2013 Mar;18(3):286-97. doi: 10.1177/1087057112462131. Epub 2012 Sep 27.
- Glucose-6-phosphate dehydrogenase (G6PD) is the key enzyme of the pentose phosphate pathway, converting glucose-6-phosphate to 6-phosphoglucono-δ-lactone with parallel reduction of NADP(+). Several human diseases, including cancer, are associated with increased G6PD activity. To date, only a few G6
- PMID 23023104
- 2-Deoxy-D-glucose and 6-aminonicotinamide-mediated Nrf2 down regulation leads to radiosensitization of malignant cells via abrogation of GSH-mediated defense.
- Sharma PK, Varshney R.SourceInstitute of Nuclear Medicine and Allied Sciences, Defence Research & Development Organization, Delhi, India.
- Free radical research.Free Radic Res.2012 Dec;46(12):1446-57. doi: 10.3109/10715762.2012.724771. Epub 2012 Oct 1.
- Enhanced level of nuclear erythroid-related factor-2 (Nrf2) has been associated with cancer chemo/radioresistance. Therefore, the role of Nrf2 in radiosensitization of malignant cells induced by a combination of 2-deoxy-D-Glucose (2-DG) and 6-aminonicotinamide (6-AN) was investigated. Two establishe
- PMID 22946929
- Radiosensitization by 2-deoxy-D-glucose and 6-aminonicotinamide involves activation of redox sensitive ASK1-JNK/p38MAPK signaling in head and neck cancer cells.
- Sharma PK, Dwarakanath BS, Varshney R.SourceInstitute of Nuclear Medicine and Allied Sciences, DRDO, Brig. S K Mazumdar Road, Delhi-110 054, India.
- Free radical biology & medicine.Free Radic Biol Med.2012 Oct 1;53(7):1500-13. doi: 10.1016/j.freeradbiomed.2012.07.001. Epub 2012 Jul 21.
- Our previous studies on simultaneous inhibition of glycolysis by 2-deoxy-D-glucose (2-DG) and pentose phosphate activity by 6-aminonicotinamide (6-AN) have been shown to induce oxidative stress mediated selective radiosensitization in wide range of human malignant cells. However, the mechanism of ra
- PMID 22824861
Japanese Journal
- Congenital Hydrocephalus and Associated Hydromyelia : A Pathological Study in Experimental Rat Model
- BABAPOUR Babak,OI Shizuo,KLEKAMP Jorg,BOOZARI Bita,HUSSEIN Sami,SAMII Madjid
- 小児の脳神経 27(3), 243-249, 2002-06-30
- NAID 50000570616
- Metallothionein 1+2 protect the CNS during neuroglial degeneration induced by 6-aminonicotinamide
- PENKOWA M
- J. Comp. Neurol. 444, 174-189, 2002
- NAID 30002181548
- Investigation of 6-aminonicotinamide-induced anomalies and their critical periods in rats
- Horie N.,Higuchi H.,Kawamura S.,Kamita Y.,Seki T.
- Congenital anomalies 41(3), 265, 2001-09
- NAID 110002785915
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- 6-Aminonicotinamide (6-AN) is a well-established inhibitor of the NADP +-dependent enzyme, 6-phosphogluconate dehydrogenase (K i = 0.46 μM). 1 Through this action, 6-AN interferes with glycolysis, resulting in ATP depletion and ...
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★リンクテーブル★
| リンク元 | 「6-アミノニコチンアミド」 |
「6-アミノニコチンアミド」
- 英
- 6-aminonicotinamide, 6-AN
- ペントースリン酸経路の最初の反応を規定する律速酵素である、グルコース6-リン酸デヒドロゲナーゼ G6PDを阻害することが知られている。
- G6PD阻害物質の1つ：ヒドロエピアンドロステロン(DHEA)と6-アミノニコチンアミド(6AN)がしられている。