5-ヒドロペルオキシエイコサテトラエン酸
WordNet
- street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
- any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
- having the characteristics of an acid; "an acid reaction"
PrepTutorEJDIC
- 酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/20 01:12:58」(JST)
[Wiki en表示]
Arachidonic acid 5-hydroperoxide
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| Identifiers |
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CAS Number
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74581-83-2 Y |
| ChemSpider |
4446295 Y |
InChI
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InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-,16-14+ Y
Key: JNUUNUQHXIOFDA-XTDASVJISA-N Y
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InChI=1/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-,16-14+
Key: JNUUNUQHXIOFDA-XTDASVJIBO
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IUPHAR/BPS
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2483 |
| Jmol interactive 3D |
Image |
| MeSH |
Arachidonic+acid+5-hydroperoxide |
| PubChem |
5280778 |
SMILES
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O=C(O)CCCC(OO)/C=C/C=C\C\C=C/C\C=C/CCCCC
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| Properties |
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Chemical formula
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C20H32O4 |
| Molar mass |
336.466 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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| Y verify (what is YN ?) |
| Infobox references |
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Arachidonic acid 5-hydroperoxide (5-hydroperoxyeicosatetraenoic acid, 5-HPETE) is an intermediate in the production of leukotriene A4, 5-Hydroxyicosatetraenoic acid and 5-oxo-eicosatetraenoic acid from arachidonic acid.
It is produced by arachidonate 5-lipoxygenase.
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Eicosanoids
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| Precursor |
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| Prostanoids |
| Prostaglandins (PG) |
| Precursor |
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| Active |
| D/J |
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| E/F |
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| I |
- I2 (Prostacyclin/Epoprostenol):
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| Thromboxanes (TX) |
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| Leukotrienes (LT) |
| Precursor |
- Arachidonic acid 5-hydroperoxide
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| Initial |
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| SRS-A |
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| Eoxins (EX) |
| Precursor |
- Arachidonic acid 15-hydroperoxide
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| Eoxins |
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| Nonclassic |
- Lipoxins (LX) (A4, B4)
- Virodhamine
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| By function |
- vasoconstriction
- vasodilation
- platelets: induce
- inhibit
- leukocytes: induce
- inhibit
- labor stimulation:
- PGE2 (Dinoprostone)
- PGF2α (Dinoprost)
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Index of inborn errors of metabolism
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| Description |
- Metabolism
- Enzymes and pathways: citric acid cycle
- pentose phosphate
- glycoproteins
- glycosaminoglycans
- phospholipid
- cholesterol and steroid
- sphingolipids
- eicosanoids
- amino acid
- urea cycle
- nucleotide
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| Disorders |
- Citric acid cycle and electron transport chain
- Glycoprotein
- Proteoglycan
- Fatty-acid
- Phospholipid
- Cholesterol and steroid
- Eicosanoid
- Amino acid
- Purine-pyrimidine
- Heme metabolism
- Symptoms and signs
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| Treatment |
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Index of biochemical families
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| Carbohydrates |
- Alcohols
- Glycoproteins
- Glycosides
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| Lipids |
- Eicosanoids
- Fatty acids
- Glycerides
- Phospholipids
- Sphingolipids
- Steroids
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| Nucleic acids |
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| Proteins |
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| Other |
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Leukotriene signaling
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Receptor
(ligands) |
| BLT |
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BLT1
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- Agonists: 12-HETE
- 20-Hydroxy-LTB4
- Leukotriene B4
- LY-255283
- Antagonists: 20-Carboxy-LTB4
- Amelubant
- CGS-23131 (LY-223982)
- CGS-25019C
- CP-105696
- CP-195543
- Etalocib
- LY-293111
- Moxilubant
- ONO-4057
- RG-14893
- RP-69698
- SB-209247
- SC-53228
- Ticolubant
- U-75302
- ZK-158252
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BLT2
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- Agonists: 12-HETE
- 12-HHT
- 12-HpETE
- 15-HETE
- 15-HpETE
- 20-Hydroxy-LTB4
- Leukotriene B4
- Antagonists: CP-195543
- LY-255283
- ZK-158252
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| CysLT |
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CysLT1
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- Agonists: Leukotriene C4
- Leukotriene D4
- Leukotriene E4
- Antagonists: Ablukast
- BAYu9773
- BAYu9916
- BAYx7195
- Cinalukast
- FPL-55712
- ICI-198615
- Iralukast
- LY-170680
- Masilukast
- MK-571
- Montelukast
- ONO-1078
- Pobilukast
- Pranlukast
- Ritolukast
- SKF-104353
- SR-2640
- Sulukast
- Tipelukast
- Tomelukast
- Verlukast
- Zafirlukast
- ZD-3523
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CysLT2
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- Agonists: Leukotriene C4
- Leukotriene D4
- Leukotriene E4
- Antagonists: BAYu9773
- BAYu9916
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CysLTE
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Enzyme
(inhibitors) |
| 5-Lipoxygenase |
- 2-TEDC
- Baicalein
- BW-A4C
- BW-B70C
- Caffeic acid
- CDC
- CJ-13610
- Curcumin
- Hyperforin
- Hypericum perforatum (St. John's Wort)
- Meclofenamic acid (meclofenamate)
- Minocycline
- N-Stearoyldopamine
- Timegadine
- Zileuton
- FLAP inhibitors: AM-103
- AM-679
- BAYx1005
- MK-591
- MK-886
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| 12-Lipoxygenase |
- 2-TEDC
- 3-Methoxytropolone
- Baicalein
- CDC
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| 15-Lipoxygenase |
- 2-TEDC
- CDC
- Luteolin
- PD-146176
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| LTA4 hydrolase |
- Captopril
- DG-051
- Fosinoprilat
- JNJ-26993135
- SA-6541
- SC-57461A
- Ubenimex (bestatin)
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| LTB4 ω-hydroxylase |
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| LTC4 synthase |
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| LTC4 hydrolase |
- Acivicin
- Serine-borate complex
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| LTD4 hydrolase |
- Cilastatin
- Ubenimex (bestatin)
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| Others |
- Precursors: Linoleic acid
- γ-Linolenic acid (gamolenic acid)
- Dihomo-γ-linolenic acid
- Diacylglycerol
- Arachidonic acid
- 5-HPETE (arachidonic acid 5-hydroperoxide)
- Leukotriene A4
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See also: Prostanoids
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UpToDate Contents
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English Journal
- Exhaled breath condensate: determination of non-volatile compounds and their potential for clinical diagnosis and monitoring. A review.
- Kubáň P1, Foret F.
- Analytica chimica acta.Anal Chim Acta.2013 Dec 17;805:1-18. doi: 10.1016/j.aca.2013.07.049. Epub 2013 Jul 31.
- Exhaled breath condensate is a promising, non-invasive, diagnostic sample obtained by condensation of exhaled breath. Starting from a historical perspective of early attempts of breath testing towards the contemporary state-of-the-art breath analysis, this review article focuses mainly on the progre
- PMID 24296139
- [Modulation of leukotriene pathway - potential targets].
- Peter H1, Lýdia B.
- Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a Slovenské farmaceutické spolecnosti.Ceska Slov Farm.2012 Jun;61(3):101-6.
- Leukotrienes (LT), namely cysteinyl LT and LTB4, are potent lipid mediators taking part in the signal pathways of many inflammatory processes. The arachidonic acid transformation into leukotrienes can be signed as the leukotriene pathway. The key enzyme is 5-lipoxygenase, a dioxygenase containing a
- PMID 22913825
- Structure and ligand based drug design strategies in the development of novel 5- LOX inhibitors.
- Aparoy P1, Reddy KK, Reddanna P.
- Current medicinal chemistry.Curr Med Chem.2012;19(22):3763-78.
- Lipoxygenases (LOXs) are non-heme iron containing dioxygenases involved in the oxygenation of polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA). Depending on the position of insertion of oxygen, LOXs are classified into 5-, 8-, 9-, 12- and 15-LOX. Among these, 5-LOX is the most predo
- PMID 22680930
Japanese Journal
- Role of Leukotriene B4 in 5-Lipoxygenase Metabolite- and Allergy-Induced Itch-Associated Responses in Mice
- Cellular Glutathione Peroxidase as a Predominant Scavenger of Hydroperoxyeicosatetraenoic Acids in Rabbit Alveolar Macrophages
- Determination of 5-hydroperoxyeicosatetraenoic acid produced in rat basophilic leukemia cell line RBL-2H3 by high-performance liquid chromatography with chemiluminescence detection
- Journal of chromatography. B, Biomedical sciences and applications 728(1), 35-40, 1999-05-14
- NAID 10024536896
Related Links
- Hydroperoxyeicosatetraenoic acids (HPETEs), hydroperoxy intermediates of arachidonic acid, have been recently reported to play an important role in regulating and modulating various cell functions such as secretion of hormones ...
- ChemExper Chemical Directory is a free service that allows to find a chemical by its molecular formula, IUPAC name, common name, CAS number, catalog number, substructure or physical characteristics. This database contains ...
★リンクテーブル★
[★]
- 英
- 5-hydroperoxyeicosatetraenoic acid, 5-HPETE
[★]
ヒドロペルオキシエイコサテトラエン酸