street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
having the characteristics of an acid; "an acid reaction"
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
4-Hydroxyphenylpyruvic acid (4-HPPA) is an intermediate in the metabolism of the amino acid phenylalanine. The aromatic side chain of phenylalanine is hydroxylated by the enzyme phenylalanine hydroxylase to form tyrosine. The conversion from tyrosine to 4-HPPA is in turn catalyzed by tyrosine aminotransferase.[1] Additionally, 4-HPPA can be converted to homogentisic acid which is one of the precursors to ochronotic pigment.[2]
It is an intermediary compound in the biosynthesis of scytonemin.
See also
4-Hydroxyphenylpyruvate dioxygenase
References
^Brand, Larry; Harper, Alfred (1974). "Effect of glucagon on phenylalanine metabolism and phenylalanine-degrading enzymes in the rat". Biochemical Journal. 142 (2): 231–45. PMC 1168273. PMID 4155291.
^Denoya, Claudio; Skinner, Deborah; Morgenstern, Margaret (September 1994). "A Streptomyces avermitilis gene encoding a 4-hydroxyphenylpyruvic acid dioxygenase-like protein that directs the production of homogentisic acid and an ochronotic pigment in Escherichia coli". Journal of Bacteriology. 1 (17): 5312–5319. Retrieved 18 July 2011.
5. 疾患予防におけるビタミン補給 vitamin supplementation in disease prevention
English Journal
Mechanistic insights into Mg2+-independent prenylation by CloQ from classical molecular mechanics and hybrid quantum mechanics/molecular mechanics molecular dynamics simulations.
Bayse CA1, Merz KM.
Biochemistry.Biochemistry.2014 Aug 5;53(30):5034-41. doi: 10.1021/bi500531p. Epub 2014 Jul 25.
Understanding the mechanism of prenyltransferases is important to the design of engineered proteins capable of synthesizing derivatives of naturally occurring therapeutic agents. CloQ is a Mg(2+)-independent aromatic prenyltransferase (APTase) that transfers a dimethylallyl group to 4-hydroxyphenylp
p-Hydroxyphenylpyruvate, an intermediate of the Phe/Tyr catabolism, improves mitochondrial oxidative metabolism under stressing conditions and prolongs survival in rats subjected to profound hemorrhagic shock.
PloS one.PLoS One.2014 Mar 5;9(3):e90917. doi: 10.1371/journal.pone.0090917. eCollection 2014.
The aim of this study was to test the effect of a small volume administration of p-hydroxyphenylpyruvate (pHPP) in a rat model of profound hemorrhagic shock and to assess a possible metabolic mechanism of action of the compound. The results obtained show that hemorrhaged rats treated with 2-4% of th
Effect of amino acids on the formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in creatinine/phenylalanine and creatinine/phenylalanine/4-oxo-2-nonenal reaction mixtures.
Zamora R1, Alcón E, Hidalgo FJ.
Food chemistry.Food Chem.2013 Dec 15;141(4):4240-5. doi: 10.1016/j.foodchem.2013.06.036. Epub 2013 Jun 18.
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) formation in mixtures of creatinine, phenylalanine, amino acids and 4-oxo-2-nonenal was studied, to analyse the role of amino acids on the generation of this heterocyclic aromatic amine. When oxidised lipid was absent, cysteine, serine, aspartic
Production of 4-hydroxyphenyllactic acid by Lactobacillus sp. SK007 fermentation(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
Mu Wanmeng,Yang Yu,Jia Jianghua [他],Zhang Tao,Jiang Bo
Journal of bioscience and bioengineering 109(4), 369-371, 2010-04
… The production of 4-hydroxyphenyllactic acid (4-HO-PLA), a novel antifungal compound, was studied in Lactobacillus sp. … When grown in MRS broth, the strain could produce 75μg/ml HO-4-PLA, which was the highest reported so far. …
A nonsense mutation in the 4-hydroxyphenylpyruvicacid dioxygenase gene (Hpd) causes skipping of the constitutive exon and hypertyrosinemia in mouse strain III