3-oxoacyl-(acyl-carrier-protein) synthase

3-オキソアシル・アシルキャリアータンパク質合成酵素

WordNet

1. an inactive substance that is a vehicle for a radioactive tracer of the same substance and that assists in its recovery after some chemical reaction
2. (genetics) an organism that possesses a recessive gene whose effect is masked by a dominant allele; the associated trait is not apparent but can be passed on to offspring
3. a rack attached to a vehicle; for carrying luggage or skis or the like
4. a self-propelled wheeled vehicle designed specifically to carry something; "refrigerated carriers have revolutionized the grocery business"
5. someone whose employment involves carrying something; "the bonds were transmitted by carrier" (同)bearer, toter
6. a person or firm in the business of transporting people or goods or messages (同)common_carrier
7. (medicine) a person (or animal) who has some pathogen to which he is immune but who can pass it on to others (同)immune carrier
8. a boy who delivers newspapers (同)newsboy
9. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
10. any group or radical of the form RCO- where R is an organic group; "an example of the acyl group is the acetyl group" (同)acyl_group

PrepTutorEJDIC

1. 『運搬する人』;輸送業者(会社) / 運搬する物,運客車;運客設備 / (…の)媒介体,保菌者《+『of』+『名』》 / (また『aircraft carrier』)航空母艦 / (自転車・車の)荷台
2. 蛋白(たんばく)質

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/07/30 18:34:22」(JST)

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3-oxoacyl-[acyl-carrier-protein] synthase
Identifiers
EC number	2.3.1.41
CAS number	9077-10-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a beta-ketoacyl-acyl-carrier-protein synthase I (EC 2.3.1.41) is an enzyme that catalyzes the chemical reaction

an acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] a 3-oxoacyl-[acyl-carrier-protein] + CO₂ + [acyl-carrier-protein]

Thus, the two substrates of this enzyme are [[acyl-[acyl-carrier-protein]]] and [[malonyl-[acyl-carrier-protein]]], whereas its 3 products are [[3-oxoacyl-[acyl-carrier-protein]]], CO₂, and acyl carrier protein.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating). Other names in common use include beta-ketoacyl-ACP synthase I, beta-ketoacyl synthetase, beta-ketoacyl-ACP synthetase, beta-ketoacyl-acyl carrier protein synthetase, beta-ketoacyl-[acyl carrier protein] synthase, beta-ketoacylsynthase, condensing enzyme, 3-ketoacyl-acyl carrier protein synthase, fatty acid condensing enzyme, acyl-malonyl(acyl-carrier-protein)-condensing enzyme, acyl-malonyl acyl carrier protein-condensing enzyme, beta-ketoacyl acyl carrier protein synthase, 3-oxoacyl-[acyl-carrier-protein] synthase, 3-oxoacyl:ACP synthase I, KASI, KAS I, FabF1, and FabB. This enzyme participates in fatty acid biosynthesis.

Structural studies

As of late 2007, 56 structures have been solved for this class of enzymes, with PDB accession codes 1B3N, 1DD8, 1E5M, 1EBL, 1EK4, 1F91, 1FJ4, 1FJ8, 1G5X, 1H4F, 1HN9, 1HND, 1HNH, 1HNJ, 1HNK, 1HZP, 1J3N, 1KAS, 1M1M, 1MZJ, 1MZS, 1OX0, 1OXH, 1TQY, 1U6E, 1U6S, 1UB7, 1W0I, 1ZOW, 2AHB, 2AJ9, 2ALM, 2AQ7, 2AQB, 2BUH, 2BUI, 2BYW, 2BYX, 2BYY, 2BYZ, 2BZ3, 2BZ4, 2C9H, 2EBD, 2EFT, 2GFV, 2GFW, 2GFX, 2GFY, 2GP6, 2GQD, 2GYO, 2IWY, 2IWZ, 2IX4, and 2PFF.

References

• Alberts AW, Majerus PW and Vagelos PR (1969). [7] Acetyl-CoA acyl carrier protein transacylase. "Acetyl-CoA acyl carrier protein transacylase". Methods Enzymol. Methods in Enzymology 14: 50–53. doi:10.1016/S0076-6879(69)14009-4. ISBN 978-0-12-181871-5. 
• Prescott DJ, Vagelos PR (1972). "Acyl carrier protein". Adv. Enzymol. Relat. Areas. Mol. Biol. 36: 269–311. PMID 4561013. 
• Toomey RE, Wakil SJ (1966). "Studies on the mechanism of fatty acid synthesis. XVI. Preparation and general properties of acyl-malonyl acyl carrier protein-condensing enzyme from Escherichia coli". J. Biol. Chem. 241 (5): 1159–65. PMID 5327099. 
• D'Agnolo G, Rosenfeld IS, Vagelos PR (1975). "Multiple forms of beta-ketoacyl-acyl carrier protein synthetase in Escherichia coli". J. Biol. Chem. 250 (14): 5289–94. PMID 237914. 
• Garwin JL, Klages AL, Cronan JE Jr (1980). "Structural, enzymatic, and genetic studies of beta-ketoacyl-acyl carrier protein synthases I and II of Escherichia coli". J. Biol. Chem. 255 (24): 11949–56. PMID 7002930. 
• Wang H, Cronan JE (2004). "Functional replacement of the FabA and FabB proteins of Escherichia coli fatty acid synthesis by Enterococcus faecalis FabZ and FabF homologues". J. Biol. Chem. 279 (33): 34489–95. doi:10.1074/jbc.M403874200. PMID 15194690. 
• Neidhardt, F.C. (Ed.), Escherichia coli and Salmonella: Cellular and Molecular Biology, 2nd ed., vol. 1, ASM Press, Washington, DC, 1996, p. 612-636.

UpToDate Contents

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• 5. 呼気中一酸化窒素の分析 exhaled nitric oxide analysis

Japanese Journal

• A homologue of the 3-oxoacyl-(acyl carrier protein) synthase III gene located in the glycosylation island of Pseudomonas syringae pv. tabaci regulates virulence factors via N-acyl homoserine lactone and fatty acid synthesis

• Taguchi Fumiko,Ogawa Yujiro,Takeuchi Kasumi,Suzuki Tomoko,Toyoda Kazuhiro,Shiraishi Tomonori,Ichinose Yuki
• Journal of Bacteriology 188(24), 8376-8384, 2006-12
• … This region is composed of three open reading frames: orf1, orf2, and orf3. … on the other hand, orf3 has no role in posttranslational modification of flagellin. … Although the function of Orf3 remained unclear, an orf3 deletion mutant (Delta orf3 mutant) had reduced virulence on tobacco plants. …
• NAID 120002314062

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• What does 3-oxoacyl-(acyl-carrier-protein) synthase mean?

U.S. National Library of Medicine 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase An enzyme of long-chain fatty acid synthesis, that adds a two-carbon unit from malonyl-(acyl carrier protein) to another molecule of fatty acyl-(acyl carrier ...

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★リンクテーブル★

関連記事	「synthase」「carrier」

「synthase」

　　[★]

• n.

• (脱離酵素リアーゼの逆反応である合成方向の反応を指す) シンターゼ, 合成酵素, 付加酵素

関

lyase、synthetase、transferase

「carrier」

　　[★]

• n.

• 運搬体