2-aminoadipate transaminase

2-アミノアジピン酸トランスアミナーゼ

WordNet

1. a class of transferases that catalyze transamination (that transfer an amino group from an amino acid to another compound) (同)aminotransferase, aminopherase

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/12 01:03:11」(JST)

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2-aminoadipate transaminase
Identifiers
EC number	2.6.1.39
CAS number	9033-00-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 2-aminoadipate transaminase (EC 2.6.1.39) is an enzyme that catalyzes the chemical reaction

L-2-aminoadipate + 2-oxoglutarate 2-oxoadipate + L-glutamate

Thus, the two substrates of this enzyme are L-2-aminoadipate and 2-oxoglutarate, whereas its two products are 2-oxoadipate and L-glutamate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-2-aminoadipate:2-oxoglutarate aminotransferase. Other names in common use include alpha-aminoadipate aminotransferase, 2-aminoadipate aminotransferase, 2-aminoadipic aminotransferase, glutamic-ketoadipic transaminase, and glutamate-alpha-ketoadipate transaminase. This enzyme participates in lysine biosynthesis and lysine degradation. It employs one cofactor, pyridoxal phosphate.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2DTV.

References

• Matsuda M, Ogur M (1969). "Separation and specificity of the yeast glutamate-alpha-ketoadipate transaminase". J. Biol. Chem. 244 (12): 3352–8. PMID 5792664. 

UpToDate Contents

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English Journal

• Molecular characterization of lysR-lysXE, gcdR-gcdHG and amaR-amaAB operons for lysine export and catabolism: a comprehensive lysine catabolic network in Pseudomonas aeruginosa PAO1.

• Madhuri Indurthi S1, Chou HT1, Lu CD2.
• Microbiology (Reading, England).Microbiology.2016 May;162(5):876-88. doi: 10.1099/mic.0.000277. Epub 2016 Mar 11.
• Among multiple interconnected pathways for l-Lysine catabolism in pseudomonads, it has been reported that Pseudomonas aeruginosa PAO1 employs the decarboxylase and the transaminase pathways. However, up until now, knowledge of several genes involved in operation and regulation of these pathways was
• PMID 26967762

• Both BAT1 and ARO8 are responsible for unpleasant odor generation in halo-tolerant yeast Zygosaccharomyces rouxii.

• Watanabe J1, Uehara K, Mogi Y.
• Applied microbiology and biotechnology.Appl Microbiol Biotechnol.2015 Sep;99(18):7685-97. doi: 10.1007/s00253-015-6673-3. Epub 2015 May 17.
• Soy sauce yeast Zygosaccharomyces rouxii plays a central role in the production of flavor compounds in soy sauce, while the flor-forming strain spoils its quality by producing 2-methylpropanoic acid, 2-methylbutanoic acid, and 3-methylbutanoic acid, which have an unpleasant odor. To investigate the
• PMID 25982000

• Domain characterization of Bacillus subtilis GabR, a pyridoxal 5'-phosphate-dependent transcriptional regulator.

• Okuda K1, Ito T1, Goto M2, Takenaka T1, Hemmi H1, Yoshimura T3.
• Journal of biochemistry.J Biochem.2015 Sep;158(3):225-34. doi: 10.1093/jb/mvv040. Epub 2015 Apr 23.
• Bacillus subtilis GabR is a transcriptional regulator consisting of a helix-turn-helix N-terminal DNA-binding domain, a pyridoxal 5'-phosphate (PLP)-binding C-terminal domain that has a structure homologous to aminotransferases, and a linker of 29 amino acid residues. In the presence of γ-aminobuty
• PMID 25911692

Related Links

• 2-aminoadipate transaminase

2-aminoadipate transaminase 2-ami·no·ad·i·pate trans·am·i·nase (ə-me″no-ə-dipґāt trans-amґĭ-nās) [EC 2.6.1.39] an enzyme of the transferase class that catalyzes the oxidative deamination of α-ketoglutarate to form glutamate. The ...

• 2-Aminoadipate transaminase - Springer

EC number 2.6.1.39 Systematic name l,-2-aminoadipate:2-oxoglutarate aminotransferase Recommended name 2-aminoadipate transaminase Synonyms 2-aminoadipate aminotransferase 2-aminoadipic aminotransferase AADAT <3 ...

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★リンクテーブル★

リンク元	「2-アミノアジピン酸トランスアミナーゼ」
関連記事	「aminoadipate」「transaminase」

「2-アミノアジピン酸トランスアミナーゼ」

　　[★]

英

2-aminoadipate transaminase

「aminoadipate」

　　[★]

• アミノアジピン酸、アミノアジピン酸塩

関

aminoadipic acid

「transaminase」

　　[★] トランスアミナーゼ