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- 1. 妊娠中の喘息の管理 management of asthma during pregnancy
- 2. 喘息の治療において5-リポキシゲナーゼ経路に影響する薬剤 agents affecting the 5 lipoxygenase pathway in the treatment of asthma
- 3. 炎症性腸疾患治療におけるスルファサラジンおよび5-アミノサリチル酸の薬理学および
作用機序 pharmacology and mechanisms of action of sulfasalazine and 5 aminosalicylates in the treatment of inflammatory bowel disease - 4. 関節リウマチの病因 pathogenesis of rheumatoid arthritis
- 5. ハーブ剤および栄養補助食品による肝毒性 hepatotoxicity due to herbal medications and dietary supplements
English Journal
- Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties.
- Eleftheriadis N1, Poelman H1, Leus NG1, Honrath B2, Neochoritis CG3, Dolga A4, Dömling A3, Dekker FJ5.
- European journal of medicinal chemistry.Eur J Med Chem.2016 Oct 21;122:786-801. doi: 10.1016/j.ejmech.2016.07.010. Epub 2016 Jul 9.
- The enzyme 15-lipoxygenase-1 (15-LOX-1) plays a dual role in diseases with an inflammatory component. On one hand 15-LOX-1 plays a role in pro-inflammatory gene expression and on the other hand it has been shown to be involved in central nervous system (CNS) disorders by its ability to mediate oxida
- PMID 27477687
- 8-Farnesyloxycoumarin induces apoptosis in PC-3 prostate cancer cells by inhibition of 15-lipoxygenase-1 enzymatic activity.
- Hosseinymehr M1, Matin MM, Sadeghian H, Bahrami AR, Kaseb-Mojaver N.
- Anti-cancer drugs.Anticancer Drugs.2016 Oct;27(9):854-62. doi: 10.1097/CAD.0000000000000399.
- Prostate cancer is the second most common cancer in men worldwide. Overexpression of 15-lipoxygenase-1 (15-LOX-1) has been reported in prostate cancer patients. This study aimed to investigate the cytotoxic and anticancer effects of 8-farnesyloxycoumarin (8f), a prenylated coumarin, by inhibition of
- PMID 27362790
- Estradiol-17β increases 12- and 15-lipoxygenase (type2) expression and activity and reactive oxygen species in human umbilical vascular smooth muscle cells.
- Somjen D1, Kohen F2, Limor R3, Sharon O3, Knoll E3, Many A3, Stern N3.
- The Journal of steroid biochemistry and molecular biology.J Steroid Biochem Mol Biol.2016 Oct;163:28-34. doi: 10.1016/j.jsbmb.2016.03.032. Epub 2016 Mar 28.
- The net vascular effect of estrogens on the vasculature is still under debate. Here we tested the effects of estradiol- 17β (E2) as well as estrogen-receptor subtype specific and non-specific agonists and antagonists on the expression and eicosanoid production of lipoxygenase (LO) enzymes expressed
- PMID 27033413
Japanese Journal
- Bongkrekic acid as a selective activator of the peroxisome proliferator-activated receptor γ (PPARγ) isoform
- The Journal of Toxicological Sciences 40(2), 223-233, 2015
- NAID 130004904039
- Identification of 14,20-dihydroxy-docosahexaenoic acid as a novel anti-inflammatory metabolite
- The journal of biochemistry 156(6), 315-321, 2014-12
- NAID 40020308548
- 糖尿病性心筋症の発症におけるアラキドン酸12/15-Lipoxygenaseのシグナル伝達機構 (第131回成医会総会一般演題)
- 東京慈恵会医科大学雑誌 129(6), 216-217, 2014-11-15
- NAID 120005531535
Related Links
- 15-Lipoxygenase Inhibitor I is a heterocyclic pyrimidobenzothiazine compound which inhibits 15-LO with an IC 50 value of 18 μM. Studies indicate that 15-Lipoxygenase has biological significance as a mediator of inflammation ...
- Mammalian erythroid cell-specific 15-lipoxygenase (EC 1.13.11.33 InterPro IPR001885). Rabbit 15-lipoxygenase (blue) with inhibitor (yellow) bound in the active site 3D structure The crystal structures of soybean and rabbit The ...
Related Pictures
★リンクテーブル★
| リンク元 | 「15-リポキシゲナーゼ」 |
| 拡張検索 | 「arachidonate 15-lipoxygenase」 |
| 関連記事 | 「lipoxygenase」 |