βシート
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- 1. アミロイド疾患の遺伝的要因genetic factors in the amyloid diseases [show details]
… which undergo conformational changes that lead to the adoption of a predominantly antiparallel beta-pleated sheet configuration . Amyloid deposits appear as amorphous hyaline material on light microscopy …
- 2. 食物アレルゲンの分子機能molecular features of food allergens [show details]
…repetitive sequences adopt rapidly interconverting beta-turn and beta-sheet secondary structures that tend to form aggregates linked by intermolecular beta sheets . The formation of such structures renders the …
- 3. 免疫グロブリン軽鎖（AL）アミロイドーシスおよび軽鎖重鎖沈着症の病因pathogenesis of immunoglobulin light chain al amyloidosis and light and heavy chain deposition diseases [show details]
…of insoluble fibrils as a result of protein misfolding. These fibrils have an antiparallel beta-pleated sheet configuration (noted on X-ray diffraction), and can be identified on biopsy specimens both …
- 4. インスリン受容体の構造および機能structure and function of the insulin receptor [show details]
…engages a nonpolar groove in the L1 beta-sheet (Leu 36, Leu 27, Leu 62, and Phe 64). It is located in volume that is normally occupied by the C-terminus of the insulin beta-chain (B26 to 30) in the structure …
- 5. 移植免疫transplantation immunobiology [show details]
…similar. They each contain a beta-pleated sheet that provides a platform supporting two alpha-helical regions, thus forming a groove in which rests a peptide antigen The beta-pleated regions are relatively …
Japanese Journal
- 神経変性疾患ポリグルタミン病に対するタンパク質凝集阻害薬QAI1の同定とその治療効果
- 永井 義隆,和田 圭司,小野寺 理,皆川 栄子,ポピエル ヘレナ明子,山根 宏志,他田 正義,髙橋 俊昭,武内 敏秀,望月 秀樹,戸田 達史
- 日本薬理学会年会要旨集 93(0), 2-O-069, 2020
- … The expansion of the polyQ stretch triggers abnormal β-sheet conformational transition and aggregation of polyQ-containing proteins, leading to neurodegeneration. … We revealed QAI1 exerts its anti-aggregation property by inhibiting the upstream toxic β-sheet conformational transition of polyQ proteins. …
- NAID 130007811563
- Three Structural Features of Functional Food Components and Herbal Medicine with Amyloid β42 Anti-Aggregation Properties
- Murakami Kazuma,Irie Kazuhiro
- Molecules 24(11), 2019-06-05
- … Aggregation of amyloid β42 (Aβ42) is one of the hallmarks of Alzheimer's disease (AD). … There are numerous naturally occurring products that suppress the aggregation of Aβ42, but the underlying mechanisms remain to be elucidated. …
- NAID 120006644072
- Importance of the Proximity and Orientation of Ligand-Linkage to the Design of Cinnamate-GW9662 Hybrid Compounds as Covalent PPARγ Agonists
- 礒田 博子,宮前 友策,Yuki Utsugi,Hirona Kobuchi,Yukio Kawamura,Ahmed Salahelden Aboelhamd Atito,Masaya Nagao,Hiroko ISODA,Yusaku MIYAMAE
- Molecules 24(10), 2019, 2019-05
- … Docking studies suggested that the activation profile likely depends on interaction with the cavity around helix 3, β-sheet, and Ω-loop region in the ligand-binding domain. …
- NAID 120006726399
Related Links
- 特徴や結合、αヘリックスとβシートの違いなど！ 公開日:2019/04/16 最終更新日:2020/03/31 カテゴリー： アミノ酸・タンパク質 α-ヘリックス β-シート イオン結合 ジスルフィド結合 タンパク質 一次構造 三次構造 二次構造 分子間力 四次構造
- ベータプリーツシート：βシートは、2つ以上のβ鎖をH結合によって連結することによって形成される。 ボンド アルファヘリックス：アルファヘリックスは、n ＋ 4個のH結合スキームを有する。すなわち、あるアミノ酸残基のN − H基と他の
- 平行βシート，逆平行βシートを描き，水素結合の方 向を確認せよ． αらせんは5 1水素結合，βターンは4 1水素結 合である．平行βシート，逆平行βシートのそれぞれ について，水素結合パターンの規則を述べよ．
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β構造。βシート構造
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