endostatin
- XVIII型コラーゲンの分解産物
- angiostatic factor(anti-angiogenesis)
- angiogenic factors such as VEGF and bFGF have relatively long half-lives in the blood compared with angiostatic factos such as endostain or angiostatin.
- large tumors often produce sufficient amounts of angiostatic factors to suppress the growth of blood vessels in small, undetectable tumors present elsewhere in the body.