|
|
nonseminoma
|
seminoma
|
| GOOD PROGNOSIS
|
Testis/retroperitoneal primary and
|
Any primary site and
|
| No nonpulmonary visceral metastases and
|
No nonpulmonary
|
| Good markers ? all of:
|
Normal AFP, any hCG, any LDH
|
| AFP < 1000 ng/ml and
|
|
| hCG < 5000 iu/l
|
| LDH < 1.5 × upper limit of normal
|
| 56% of nonseminomas
|
90% of seminomas
|
| 5-year PFS 89%
|
5-year PFS 82%
|
| 5-year survival 92%
|
5-year survival 86%
|
| INTERMEDIATE PROGNOSIS
|
Testis/retroperitoneal primary and
|
Any primary site and
|
| No nonpulmonary visceral metastases and
|
Nonpulmonary visceral metastases and
|
| Intermediate markers ? any of:
|
Normal AFP, any hCG, any LDH
|
| AFP ? 1000 and ? 50,000 iu/l or
|
|
| hCG ? 5000 iu/l and ? 50 000 iu/l
|
| LDH ? 1.5 × N and ? 10 × N
|
| 28% of nonseminomas
|
10% of seminomas
|
| 5-year PFS 75%
|
5-year PFS 67%
|
| 5-year survival 80%
|
5-year survival 72%
|
| POOR PROGNOSIS
|
Mediastinal primary or
|
No patients classified and poor prognosis
|
| Nonpulmonary visceral metastases or
|
|
| Poor markers ? any of:
|
| AFP > 10,000 ng/mL or
|
| hCG > 50,000 IU/L (10000ng/mL) or
|
| LDH > 10 × upper limit of normal
|
| 16% of nonseminomas
|
| 5-year PFS 41%
|
| 5-year survival 48%
|