デスモプレシン
- 英
- desmopressin
- 同
- 1-desamino-8-D-arginine vasopressin, DDAVP, 1-deamino-8-D-arginine vasopressin、デアミノアルギニンバソプレッシン デアミノアルギニンバソプレシン deamino arginine vasopressin
- 化
- 酢酸デスモプレシン desmopressin acetate
- 商
- Stimate、デスモプレシン点鼻薬、デスモプレシン注、ミニリンメルト
- 関
- バソプレシン。脳下垂体ホルモン剤
- アルギニンバソプレシン誘導体;尿崩症治療薬
- 副作用の発現がバソプレシンより少ないが、水中毒にはやはり注意する必要がある。(QB.D-257)
| I. NATURALLY OCCURRING VASOPRESSIN-LIKE PEPTIDES? | |||||
| ??A. Vertebrates? | A? | W? | X? | Y? | Z? |
| ????1. Mammals | |||||
| ??????? Arginine? vasopressin* (AVP) (human beings and other mammals) | NH2 | Tyr | Phe | Gln | Arg |
| ???????Lypressin* (pigs, marsupials) | NH2 | Tyr | Phe | Gln | Lys |
| ???????Phenypressin (macropodids) | NH2 | Phe | Phe | Gln | Arg |
| ????2. Nonmammalian vertebrates | |||||
| Vasotocin | NH2 | Tyr | Ile | Gln | Arg |
| ??B. Invertebrates? | |||||
| ????1. Arginine conopressin (Conus striatus)? | NH2 | Ile | Ile | Arg | Arg |
| ????2. Lysine conopressin (Conus geographicus)? | NH2 | Phe | Ile | Arg | Lys |
| ????3. Locust subesophageal ganglia peptide | NH2 | Leu | Ile | Thr | Arg |
| II. SYNTHETIC VASOPRESSIN PEPTIDES? | |||||
| ??A. V1-selective agonists? | |||||
| ????1. V1a-Selective Agonist [Phe2, Ile3, Orn8]AVP | NH2 | Phe | Ile | Gln | Orn |
| ????2. V1b-Selective Agonist Deamino [D-3-(3'-pyridyl)-Ala2]AVP | H | D-3-(3'-pyridyl)-Ala2 | Phe | Gln | Arg |
| ??B. V2-selective agonists? | |||||
| ????1. Desmopressin* (DDAVP) | H | Tyr | Phe | Gln | D-Arg? |
| ????2. Deamino[Val4, D-Arg8]AVP | H | Tyr | Phe | Val | D-Arg? |
| III. NONPEPTIDE AGONIST? | |||||
| A. OPC-51803? | |||||