English Journal

Cancer therapy using nanoformulated substances: scientific, regulatory and financial aspects.

Alphandéry E1,2, Grand-Dewyse P1, Lefèvre R1,3, Mandawala C1,4, Durand-Dubief M1.
Expert review of anticancer therapy.Expert Rev Anticancer Ther.2015;15(10):1233-55. doi: 10.1586/14737140.2015.1086647.
Several nanoformulated anti-cancer substances are currently commercialized or under development. Pre-clinical and clinical results have revealed better properties, that is, larger efficacy and lower toxicity for these substances than for conventional anti-cancer treatments. Here, we review the devel
PMID 26402250

Urvoas A1, Ghattas W2, Maréchal JD3, Avenier F2, Bellande F2, Mao W2, Ricoux R4, Mahy JP5.
Bioorganic & medicinal chemistry.Bioorg Med Chem.2014 Oct 15;22(20):5678-86. doi: 10.1016/j.bmc.2014.05.063. Epub 2014 Jun 14.
A new zinc(II)-cofactor coupled to a testosterone anchor, zinc(II)-N,N-bis(2-pyridylmethyl)-1,3-diamino-propa-2-ol-N'(17'-succinimidyltestosterone) (Zn-Testo-BisPyPol) 1-Zn has been synthesized and fully characterized. It has been further associated with a neocarzinostatin variant, NCS-3.24, to gene
PMID 24984934

Nichols JW1, Bae YH2.
Journal of controlled release : official journal of the Controlled Release Society.J Control Release.2014 Sep 28;190:451-64. doi: 10.1016/j.jconrel.2014.03.057. Epub 2014 Apr 30.
The enhanced permeability and retention (EPR) of nanoparticles in tumors has long stood as one of the fundamental principles of cancer drug delivery, holding the promise of safe, simple and effective therapy. By allowing particles preferential access to tumors by virtue of size and longevity in circ
PMID 24794900

Japanese Journal

太田宏信,石川達,上村朝輝
新潟医学会雑誌 119(7), 402-405, 2005-07-10
… At our department, we have been actively treating HCC using multidisciplinary therapy consisting mainly of the arterial administration of Zinostatin stimalamar (SMANCS). …
NAID 110004715937

奥坂拓志
Drug delivery system 19(5), 420-428, 2004-09-10
SMANCS-Lipiodol emulsion is selectively deposited within tumor and the SMANCS is gradually released from the trapped Lipiodol into tumor tissues. SMANCS, which was developed in Japan, is one of a few …
NAID 10013648559