wakefulness

出典: meddic



WordNet   license wordnet

「a temporary state in which you are unable (or unwilling) to sleep; "accept your wakefulness and sleep in its own contrary way is more likely to come"」
sleeplessness

WordNet   license wordnet

「a periodic state during which you are conscious and aware of the world; "consciousness during wakefulness in a sane person is pretty well ordered and familiar"」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/21 12:38:10」(JST)

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英文文献

  • The CRF1 receptor antagonist SSR125543 prevents stress-induced long-lasting sleep disturbances in a mouse model of PTSD: Comparison with paroxetine and d-cycloserine.
  • Philbert J1, Beeské S1, Belzung C2, Griebel G3.
  • Behavioural brain research.Behav Brain Res.2015 Feb 15;279:41-6. doi: 10.1016/j.bbr.2014.11.006. Epub 2014 Nov 12.
  • The selective CRF1 (corticotropin releasing factor type 1) receptor antagonist SSR125543 has been previously shown to attenuate the long-term behavioral and electrophysiological effects produced by traumatic stress exposure in mice. Sleep disturbances are one of the most commonly reported symptoms b
  • PMID 25446760
  • Assessing levels of consciousness with symbolic analysis.
  • Lee U1, Blain-Moraes S2, Mashour GA3.
  • Philosophical transactions. Series A, Mathematical, physical, and engineering sciences.Philos Trans A Math Phys Eng Sci.2015 Feb 13;373(2034). pii: 20140117.
  • 'Covert consciousness' is a state in which consciousness is present without the capacity for behavioural response, and it can occur in patients with intraoperative awareness or unresponsive wakefulness syndrome. To detect and prevent this undesirable state, it is critical to develop a reliable neuro
  • PMID 25548273
  • Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant.
  • Raheem IT1, Breslin MJ1, Bruno J2, Cabalu TD3, Cooke A1, Cox CD1, Cui D3, Garson S4, Gotter AL4, Fox SV5, Harrell CM4, Kuduk SD1, Lemaire W2, Prueksaritanont T3, Renger JJ4, Stump C1, Tannenbaum PL5, Williams PD1, Winrow CJ4, Coleman PJ1.
  • Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2015 Feb 1;25(3):444-50. doi: 10.1016/j.bmcl.2014.12.056. Epub 2014 Dec 23.
  • Highly selective orexin receptor antagonists (SORAs) of the orexin 2 receptor (OX2R) have become attractive targets both as potential therapeutics for insomnia as well as biological tools to help further elucidate the underlying pharmacology of the orexin signaling pathway. Herein, we describe the d
  • PMID 25577040
  • Orexin A upregulates the protein expression of OX1R and enhances the proliferation of SGC-7901 gastric cancer cells through the ERK signaling pathway.
  • Liu Y1, Zhao Y1, Ju S1, Guo L2.
  • International journal of molecular medicine.Int J Mol Med.2015 Feb;35(2):539-45. doi: 10.3892/ijmm.2014.2038. Epub 2014 Dec 15.
  • Orexins are hypothalamic peptides that regulate food intake, wakefulness, the reward system and energy metabolism. Recent studies have demonstrated the ability of orexins to promote a robust apoptosis and subsequent inhibition of cell growth in various types of cancer cells. The present study was co
  • PMID 25515760

和文文献

  • Orexin neurons suppress narcolepsy via 2 distinct efferent pathways
  • Hasegawa Emi,Yanagisawa Masashi,Sakurai Takeshi,Mieda Michihiro
  • Journal of Clinical Investigation 124(2), 604-616, 2014-02
  • … Mice lacking orexin peptides, orexin neurons, or orexin receptors recapitulate human narcolepsy phenotypes, further highlighting a critical role for orexin signaling in the maintenance of wakefulness. … We found that targeted restoration of orexin receptor expression in the dorsal raphe (DR) and in the locus coeruleus (LC) of mice lacking orexin receptors inhibited cataplexy-like episodes and pathological fragmentation of wakefulness (i.e., sleepiness), respectively. …
  • NAID 120005411681
  • 睡眠覚醒制御におけるオレキシン受容体の機能とオレキシン受容体拮抗薬の作用
  • 桜井 武
  • 内分泌・糖尿病・代謝内科 38(1), 60-68, 2014-01
  • NAID 40019957706
  • 睡眠覚醒の制御 (特集 オプトジェネティクスを用いた神経機能操作の現在地 : 光で行動をコントロールする)
  • 体温と睡眠の概日リズム (特集 概日リズムと疾患 : 病態・診断・治療の最新知見)

関連リンク

From Wikipedia, the free encyclopedia. Jump to: navigation, search. "Awake" redirects here. For other uses, see Awake (disambiguation). "Wakeful" redirects here. For other uses, see Wakeful (disambiguation). Wakefulness is a daily recurring ...
28 Oct 2005 ... Speaking personally, I consider sleep as a chore to be postponed for as long as possible. But sleepiness is a tenacious, unrelenting adversary, and drowsin.

関連画像

wakefulnessModafinil wakefulness promoting drug Chicago Maintenance of Wakefulness TestDevoted to Wakefulness!WakefulnessAbout Contact News & Events Giving to the Sustaining Wakefulness in Excessive devoted to wakefulness! Bhikkhus, it is by


★リンクテーブル★
リンク元wake」「arouse」「awake」「rouse」「awakening

wake」

  [★]

  • v.
arousalarouseawakerousewakefulness

WordNet   license wordnet

「make aware of; "His words woke us to terrible facts of the situation"」

WordNet   license wordnet

「be awake, be alert, be there」

WordNet   license wordnet

「the wave that spreads behind a boat as it moves forward; "the motorboat''s wake capsized the canoe"」
backwash

PrepTutorEJDIC   license prepejdic

「『目を覚ます』(awake)《+up》 / 《文》目を覚ましたままでいる,寝ずにいる《+up》 / (…に)気づく,目覚める《+up to+名》 / 〈人〉‘の'『目を覚まさせる』,‘を'起こす(awaken)《+名+up,+up+名》 / 《比喩的に》(…に)…‘を'目覚めさせる,窪づかせる,活発にする《+up+名(+名+up)+to+名》 / (死者のために)通夜をする / 《おもにアイルランド・イギリス北部》通夜」

PrepTutorEJDIC   license prepejdic

「物が通った跡,(特に)航跡」

WordNet   license wordnet

「a vigil held over a corpse the night before burial; "there''s no weeping at an Irish wake"」
viewing

arouse」

  [★]

  • v.
arousalawakecallgive rise toraiserouseundergowakewakefulness

WordNet   license wordnet

「to begin moving, "As the thunder started the sleeping children began to stir"」
stir

PrepTutorEJDIC   license prepejdic

「(眠りなどから)〈人〉'を'起こす,‘の'目を覚ます《+『名』+『from』+『名』》 / 〈物事が〉〈ある行為・感情など〉'を'『呼び起こす』;…'を'刺激する(excite) / 〈物事が〉〈人〉'を'刺激して(…)させる,(…に)かり立てる《+『名』+『to』+『名』(do『ing』)》」

WordNet   license wordnet

「call forth (emotions, feelings, and responses); "arouse pity"; "raise a smile"; "evoke sympathy"」
elicit, enkindle, kindle, evoke, fire, raise, provoke

WordNet   license wordnet

「stimulate sexually; "This movie usually arouses the male audience"」
sex, excite, turn on, wind up


awake」

  [★]

  • 覚醒している
arousalarouserousewakewakefulness

WordNet   license wordnet

「not in a state of sleep; completely conscious; "lay awake thinking about his new job"; "still not fully awake"」

PrepTutorEJDIC   license prepejdic

「(…から)…‘の'『目をさまさせる』,'を'起こす《+『名』+『from』+『名』》(wake) / 〈記憶・感情など〉'を'呼び起こす,喚起する / (…を)〈人〉‘に'気づかせる,自覚させる《+『名』〈人〉+『to』+『名』》 / 目をさます / (周囲の事情などに)気がつく《+『to』+『名』》 / 『眠らずに』,『目がさめて』 / (…に)気づいている《+『to』+『名』》」


rouse」

  [★]

  • vt.
  • ~の目を覚まさせる、呼び起こす。喚起する、鼓舞する、奮起させる。(杆状を)起こさせる、かき立てる
  • vi.
  • n.


arousalarouseawakewakewakefulness

PrepTutorEJDIC   license prepejdic

「(眠り・無意所などから)〈人〉‘の'『目を覚まさせる』,‘を'起こす《+『名』〈人〉+『from』(『out of』)+『名』》 / 〈人〉‘を'『奮起させる』,刺激する / 〈感情など〉‘を'刺激する,かき立てる / 《英ではまれ》〈人が〉目を覚ます《+『up』》 / 〈人が〉奮起する,〈感情が〉激する《+『up』》」


awakening」

  [★]

arousalvigilancewakefulness

WordNet   license wordnet

「the act of waking; "it was an early awakening"; "it was the waking up he hated most"」
wakening, waking up

PrepTutorEJDIC   license prepejdic

「(…に)目ざめること,気づくこと《+『to』+『名』》 / 目ざめさせる,目ざめつつある」




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