不飽和鉄結合能
WordNet
- the amount that can be contained; "the gas tank has a capacity of 12 gallons" (同)content
- (computer science) the amount of information (in bytes) that can be stored on a disk drive; "the capacity of a hard disk drive is usually expressed in megabytes"
- a specified function; "he was employed in the capacity of director"; "he should be retained in his present capacity at a higher salary"
- the maximum production possible; "the plant is working at 80 per cent capacity"
- tolerance for alcohol; "he had drunk beyond his capacity"
- the power to learn or retain knowledge; in law, the ability to understand the facts and significance of your behavior (同)mental ability
- capability to perform or produce; "among his gifts is his capacity for true altruism"; "limited runway capacity"; "a great capacity for growth"
- press and smooth with a heated iron; "press your shirts"; "she stood there ironing" (同)iron_out, press
- a heavy ductile magnetic metallic element; is silver-white in pure form but readily rusts; used in construction and tools and armament; plays a role in the transport of oxygen by the blood (同)Fe, atomic number 26
- implement used to brand live stock (同)branding iron
- home appliance consisting of a flat metal base that is heated and used to smooth cloth (同)smoothing iron
- a golf club that has a relatively narrow metal head
- executed with proper legal authority; "a binding contract"
- the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
- strip sewn over or along an edge for reinforcement or decoration
- the capacity to attract and hold something
- used of a compound (especially of carbon) containing atoms sharing more than one valence bond; "unsaturated fats"
- (of color) not chromatically pure; diluted; "an unsaturated red"
- not saturated; capable of dissolving more of a substance at a given temperature; "an unsaturated salt solution"
- garments (clothes or linens) that are to be (or have been) ironed; "there was a basketful of ironing to do"
- the work of using heat to smooth washed clothes in order to remove any wrinkles
PrepTutorEJDIC
- 〈U〉《しばしばa capacity》(建物などの)『収容力』,(容器などの)『容量』,『容積』 / 〈U〉《しばしばa capacity》(人の)『能力』,才能;(物の)性能 / 〈C〉(…の)『資格』,地位《+『of』(『as』)+『名』》
- 〈U〉『鉄』 / 〈U〉鉄のように堅い(強い,冷たい)こと / 〈C〉鉄製の器具 / 〈C〉[電気]『アイロン』 / 〈C〉アイアン(球を打つ部分が金属のゴルフクラブ) / 〈C〉《複数形で》手かせ,足かせ / 《名詞の前にのみ用いて》『鉄の』,鉄製の / 鉄のように堅い(強い,冷たい) / …‘に'アイロンをかける / 〈人が〉アイロンをかける
- 義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
- (有機化合物が)不飽和の / (一定温度で)さらに溶解可能の
- アイロンかけ / アイロンかけをした(をする)衣類
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/11/28 01:59:32」(JST)
[Wiki en表示]
| Total iron-binding capacity |
| Diagnostics |
|
transferrin
|
| MedlinePlus |
003489 |
| LOINC |
14800-7, 35215-3, 2501-5 |
Total iron-binding capacity (TIBC) is a medical laboratory test that measures the blood's capacity to bind iron with transferrin.[1] It is performed by drawing blood and measuring the maximum amount of iron that it can carry, which indirectly measures transferrin[2] since transferrin is the most dynamic carrier. TIBC is less expensive than a direct measurement of transferrin.[3][4]
The TIBC should not be confused with the UIBC, or "unsaturated iron binding capacity" (22753-8 and 35216-1). The UIBC is calculated by subtracting the serum iron from the TIBC.[5]
Contents
- 1 Interpretation
- 2 Usual values
- 3 References
- 4 External Links
Interpretation
Taken together with serum iron and percent transferrin saturation clinicians usually perform this test when they are concerned about anemia, iron deficiency or iron deficiency anemia. However, because the liver produces transferrin, alterations in function (such as cirrhosis, hepatitis, or liver failure) must be considered when performing this test. It can also be an indirect test of liver function, but is rarely used for this purpose.
The percent transferrin saturation (i.e., the result of the formula of serum iron/TIBC x 100) can also be a useful indicator.
| Condition |
Serum iron (highly variable) |
Transferrin and TIBC |
Percent transferrin saturation |
| iron deficiency anemia |
Low |
High. The liver produces more transferrin, presumably attempting to maximize use of the little iron that is available. |
Low, as there is insufficient iron. |
| anemia of chronic disease |
Low, as the body holds iron intracellularly with ferritin. |
Low. The body produces less transferrin (but more ferritin), presumably to keep iron away from pathogens that require it for their metabolism. This is mainly regulated by increased hepcidin production. |
Normal |
| pregnancy or use of hormonal contraception, but without iron deficiency |
Normal |
High. The liver increases the production of transferrin, thus raising TIBC. |
Low, as there is excess transferrin with normal serum iron levels. |
These examples demonstrate that to properly understand a value for TIBC, one also must know the serum iron, the percent transferrin saturation, and the individual clinical situation. In modern laboratory testings, serum ferritin levels are generally accepted as reliable single indicators of the presence of iron deficiency.
Usual values
Reference ranges for blood tests, comparing blood content of iron and related compounds (shown in brown and orange) with other constituents.
Laboratories often use different units of measurement and "normal" may vary by population and the laboratory techniques used. Look at the individual laboratory reference values to interpret a specific test (for instance, your own). Example reference ranges are:
- Serum iron: Male 65–177 μg/dL (11.6–31.7 μmol/L); Female 50–170 μg/dL (9.0–30.4 μmol/L)
- TIBC: 250–370 μg/dL (45-66 μmol/L)[6]
- Transferrin saturation: Male 20–50%; Female 15–50%
- Serum ferritin: Male 20-250 μg/L, Female 15-150 μg/L[6]
μg/dL = micrograms per deciliter; μmol/L = micromoles per litre.
References
- ^ "MedlinePlus Medical Encyclopedia: Total iron binding capacity". Retrieved 2008-12-31.
- ^ Yamanishi H, Iyama S, Yamaguchi Y, Kanakura Y, Iwatani Y (January 2003). "Total iron-binding capacity calculated from serum transferrin concentration or serum iron concentration and unsaturated iron-binding capacity". Clin. Chem. 49 (1): 175–8. doi:10.1373/49.1.175. PMID 12507977.
- ^ Kasvosve I, Delanghe J (October 2002). "Total iron binding capacity and transferrin concentration in the assessment of iron status". Clin. Chem. Lab. Med. 40 (10): 1014–8. doi:10.1515/CCLM.2002.176. PMID 12476940.
- ^ Gambino R, Desvarieux E, Orth M, et al. (December 1997). "The relation between chemically measured total iron-binding capacity concentrations and immunologically measured transferrin concentrations in human serum". Clin. Chem. 43 (12): 2408–12. PMID 9439462.
- ^ "Iron Transport". Retrieved 2008-12-31.
- ^ a b Harrison's Principles of Internal Medicine. 17th Edition (2008). Pg. 2432 (Table 351-2)
External Links
- TIBC, UIBC and Transferrin Saturation at Lab Tests Online
|
Medical test: Serology, Reference range: Clinical biochemistry Blood tests
(including BMP, CMP) (CPT 82000–84999)
|
|
| Fluid/electrolytes |
- electrolytes
- renal function, BUN-to-creatinine ratio
- Ca
- derived values: Plasma osmolality
- Serum osmolal gap
|
|
| Acid-base |
- Arterial blood gas
- Base excess
- Anion gap
- CO2 content
|
|
| Nutrition |
- Iron tests: Transferrin saturation = Serum iron / Total iron-binding capacity; Ferritin
- Transferrin
- Transferrin receptor
|
|
| Endocrine |
- ACTH stimulation test
- Thyroid function tests
- Blood sugar: Glucose test
- C-peptide
- Fructosamine
- Glycated hemoglobin
|
|
| Metabolic |
|
|
| Cardiovascular |
- Cardiac marker: Troponin test
- CPK-MB test
- LDH
- Myoglobin
- Glycogen phosphorylase isoenzyme BB
|
|
| Digestive |
- Liver function tests: protein tests
- Human serum albumin
- Serum total protein
- ALP
- transaminases
- Bilirubin
|
|
|
|
|
noco/acba/cong/tumr, sysi/epon, urte
|
proc/itvp, drug (G4B), blte, urte
|
|
|
|
|
noco (d)/cong/tumr, sysi/epon
|
proc, drug (A10/H1/H2/H3/H5)
|
|
|
|
|
noco/cong/tumr, sysi/epon, injr
|
proc, drug (C1A/1B/1C/1D), blte
|
|
|
|
anat (t, g, p)/phys/devp/enzy
|
noco/cong/tumr, sysi/epon
|
proc, drug (A2A/2B/3/4/5/6/7/14/16), blte
|
|
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- INFLAMMATORY MARKERS ASSOCIATED WITH TRAUMA AND INFECTION IN RED-TAILED HAWKS (BUTEO JAMAICENSIS) IN THE USA.
- Lee KA1, Goetting VS1, Tell LA1,2.
- Journal of wildlife diseases.J Wildl Dis.2015 Aug 17. [Epub ahead of print]
- Changes in inflammatory marker concentrations or activity can be used to monitor health and disease condition of domestic animals but have not been applied with the same frequency to wildlife. We measured concentrations or activity of six inflammatory markers (ceruloplasmin, haptoglobin, mannan-
- PMID 26280876
- Anti-repulsive Guidance Molecule C (RGMc) Antibodies Increases Serum Iron in Rats and Cynomolgus Monkeys by Hepcidin Downregulation.
- Böser P1, Seemann D, Liguori MJ, Fan L, Huang L, Hafner M, Popp A, Mueller BK.
- The AAPS journal.AAPS J.2015 Jul;17(4):930-8. doi: 10.1208/s12248-015-9770-4. Epub 2015 Apr 22.
- High levels of hepcidin, the main regulator of systemic iron metabolism, lead to various diseases. Targeting hepcidin and lowering its concentration is a possible form of intervention in order to treat these diseases. High turnover rate of hepcidin is a major drawback of therapies directly targeting
- PMID 25896304
- Vitamin D, Iron Metabolism, and Diet in Alpinists During a 2-Week High-Altitude Climb.
- Kasprzak Z1, Śliwicka E1, Hennig K1, Pilaczyńska-Szcześniak Ł1, Huta-Osiecka A1, Nowak A1.
- High altitude medicine & biology.High Alt Med Biol.2015 Jun 30. [Epub ahead of print]
- Kasprzak, Zbigniew, Ewa Śliwicka, Karol Hennig, Łucja Pilaczyńska-Szcześniak, Anna Huta-Osiecka, and Alicja Nowak. Vitamin D, iron metabolism, and diet in alpinists during a 2-week high-altitude climb. High Alt Med Biol 00:000-000, 2015.-A defensive mechanism against hypobaric hypoxia at high al
- PMID 26125641
Japanese Journal
- Acidic Xylooligosaccharide Preserves Hepatic Iron Storage Level in Adult Female Rats Fed a Low-Iron Diet
- KOBAYASHI Yukiko,OHBUCHI Takayuki,FUKUDA Tomo,WAKASUGI Etsuko,YASUI Risa,HAMADA Mai,YOKOYAMA Meiko,KUWAHATA Masashi,KIDO Yasuhiro
- Journal of Nutritional Science and Vitaminology 57(4), 292-297, 2011
- … Iron deficiency anemia (IDA) is one of the most serious forms of malnutrition. … This experiment was conducted to investigate whether acidic xylooligosaccharide (U-XOS), expected to have a high iron bioavailability, was useful in the prevention of iron deficiency. … a U-XOS-supplemented low-iron diet (LI-X, n=7), a low-iron diet (LI, n=6), and a control diet (C, n=6). …
- NAID 130001373001
- 金属 鉄,総鉄結合能(TIBC),不飽和鉄結合能(UIBC) (広範囲 血液・尿化学検査 免疫学的検査(第7版・2)その数値をどう読むか) -- (生化学的検査(2))
Related Links
- The index of transferrin present in circulating blood is the iron-binding capacity. Transferrin can be nearly one third saturated with iron. The unsaturated iron-binding capacity (UIBC) is measured using radioactive iron or ...
- The measurement of unsaturated iron binding capacity (UIBC) in combination with serum iron is a useful diagnostic tool in the determination of various iron ... Each laboratory should check if the reference ranges are transferable to its ...
★リンクテーブル★
[★]
- 英
- unsaturated iron binding capacity, UIBC
- 関
- 総鉄結合能 TIBC
- 鉄結合していないトランスフェリンの量を結合可能な鉄量で表した値
- 検体の血清の「予備的な鉄結合能」
- 鉄を結合していないトランスフェリンの量に比例し、これらに鉄結合を飽和させたとき、結合しうる鉄の量を示す。(厳密には一致しない)
定義
- 減少：鉄を結合しているトランスフェリンが増加 or トランスフェリンが減少
- 増加：鉄を結合しているトランスフェリンが減少 or トランスフェリンが増加
基準値
- M:170-250 ug/dl (LAB)
- F:180-270 ug/dl (LAB)
[★]
- 関
- affinity、associate、bind、bond、bonding、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、connective、connectivity、couple、dock、engage、engagement、join、ligate、linkage、symphysial、symphysic、union
[★]
- (呼吸器)volumeの和・差はcapacityと呼ぶ傾向があるみたい
- 関
- ability、capability、capacitance、competence、competent、facility、power
[★]
- 関
- undersaturated、unsaturation
[★]
鉄