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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/01/13 13:45:22」(JST)

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  • Exposure-dependent incorporation of trifluridine into DNA of tumors and white blood cells in tumor-bearing mouse.
  • Yamashita F1, Komoto I, Oka H, Kuwata K, Takeuchi M, Nakagawa F, Yoshisue K, Chiba M.
  • Cancer chemotherapy and pharmacology.Cancer Chemother Pharmacol.2015 Jun 18. [Epub ahead of print]
  • PURPOSE: Trifluridine (TFT) is an antitumor component of a novel nucleoside antitumor agent, TAS-102, which consists of TFT and tipiracil hydrochloride (thymidine phosphorylase inhibitor). Incorporation of TFT into DNA is a probable mechanism of antitumor activity and hematological toxicity. The obj
  • PMID 26084259
  • Crucial roles of thymidine kinase 1 and deoxyUTPase in incorporating the antineoplastic nucleosides trifluridine and 2'-deoxy-5-fluorouridine into DNA.
  • Sakamoto K1, Yokogawa T1, Ueno H1, Oguchi K1, Kazuno H1, Ishida K1, Tanaka N1, Osada A1, Yamada Y1, Okabe H1, Matsuo K1.
  • International journal of oncology.Int J Oncol.2015 Jun;46(6):2327-34. doi: 10.3892/ijo.2015.2974. Epub 2015 Apr 20.
  • Trifluridine (FTD) and 2'-deoxy-5-fluorouridine (FdUrd), a derivative of 5-fluorouracil (5-FU), are antitumor agents that inhibit thymidylate synthase activity and their nucleotides are incorporated into DNA. However, it is evident that several differences occur in the underlying antitumor mechanism
  • PMID 25901475
  • Randomized trial of TAS-102 for refractory metastatic colorectal cancer.
  • Mayer RJ, Van Cutsem E, Falcone A, Yoshino T, Garcia-Carbonero R, Mizunuma N, Yamazaki K, Shimada Y, Tabernero J, Komatsu Y, Sobrero A, Boucher E, Peeters M, Tran B, Lenz HJ, Zaniboni A, Hochster H, Cleary JM, Prenen H, Benedetti F, Mizuguchi H, Makris L, Ito M, Ohtsu A; RECOURSE Study Group.
  • The New England journal of medicine.N Engl J Med.2015 May 14;372(20):1909-19. doi: 10.1056/NEJMoa1414325.
  • BACKGROUND: Early clinical trials conducted primarily in Japan have shown that TAS-102, an oral agent that combines trifluridine and tipiracil hydrochloride, was effective in the treatment of refractory colorectal cancer. We conducted a phase 3 trial to further assess the efficacy and safety of TAS-
  • PMID 25970050


  • Delivery of trifluridine to human cornea and aqueous using collagen shields
  • A prospective, masked clinical trial of trifluridine, dexamethasone, and artificial tears in the treatment of epidemic keratoconjunctivitis


trifluridine [tri-floor´ĭ-dēn] an antiviral compound that interferes with viral DNA synthesis, used topically in the treatment of keratitis and keratoconjunctivitis caused by human herpesviruses 1 and 2. trifluridine /tri·flur·i·dine/ (-floor´ĭ-dēn ...
Trifluridine official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. ... General Trifluridine Ophthalmic Solution, 1% should be prescribed only for patients ...


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