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  • Expression of plasminogen activator inhibitor-1 by olfactory ensheathing glia promotes axonal regeneration.
  • Simon D, Martin-Bermejo MJ, Gallego-Hernandez MT, Pastrana E, Garcia-Escudero V, Garcia-Gomez A, Lim F, Diaz-Nido J, Avila J, Moreno-Flores MT.SourceCentro de Biologia Molecular Severo Ochoa (CSIC-UAM), Universidad Autonoma de Madrid, Madrid, Spain.
  • Glia.Glia.2011 Oct;59(10):1458-71. doi: 10.1002/glia.21189. Epub 2011 May 27.
  • Olfactory ensheathing glia (OEG) cells are known to facilitate repair following axotomy of adult neurons, although the molecular mechanisms involved are not fully understood. We previously identified plasminogen activator inhibitor-1 (PAI-1), proteinase-activated receptor-1 (PAR-1), and thrombomodul
  • PMID 21626571
  • Endothelial dysfunction and low-grade inflammation are associated with greater arterial stiffness over a 6-year period.
  • van Bussel BC, Schouten F, Henry RM, Schalkwijk CG, de Boer MR, Ferreira I, Smulders YM, Twisk JW, Stehouwer CD.SourceDepartment of Medicine, Prof Debyelaan 25, 6229 HX Maastricht, The Netherlands.
  • Hypertension.Hypertension.2011 Oct;58(4):588-95. Epub 2011 Aug 22.
  • Endothelial dysfunction and low-grade inflammation are associated with cardiovascular disease. Arterial stiffening plays an important role in cardiovascular disease and, thus, may be a mechanism through which endothelial dysfunction and/or low-grade inflammation lead to cardiovascular disease. We in
  • PMID 21859964


  • 急性骨髄性白血病寛解導入療法後に発症した溶血性尿毒症性症候群の1例
  • 加藤 裕一,田嶋 克史,加藤 丈夫
  • 山形大学紀要. 医学 : 山形医学 29(1), 29-31, 2011-02-15
  • A 75-year-old male was diagnosed with acute myeloid leukemia without maturation and was treated with combination chemotherapy. After the first remission-induction therapy, he reached complete remissio …
  • NAID 110008576606
  • 創薬シリーズ(5)トランスレーショナルリサーチ(24)トランスレーショナルリサーチからみた遺伝子組換え型ヒトトロンボモジュリン製剤(リコモジュリン)開発
  • 本田 剛一,鈴木 秀明,青木 喜和
  • 日本薬理学雑誌 138(2), 56-59, 2011-08
  • NAID 40018932250


Thrombomodulin, CD141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells. In humans, thrombomodulin is encoded by the THBD gene. The protein has a molecular mass of 74kDa, and consists of a ...


Thrombomodulin thrombomodulin (TM)-activated protein CSepsis leads to organ failure and death When the blood pressure increases here the thrombomodulin -proteinThrombomodulin




endothelium (Z)

Table 10-1. Endothelial Cell Properties and Functions
Maintenance of Permeability Barrier
Elaboration of Anticoagulant, Antithrombotic, Fibrinolytic Regulators
heparin-like molecules
plasminogen activator
Elaboration of Prothrombotic Molecules
Von Willebrand factor
Tissue factor
Plasminogen activator inhibitor
Extracellular Matrix Production (Collagen, Proteoglycans)
Modulation of Blood Flow and Vascular Reactivity
Vasconstrictors: endothelin, ACE
Vasodilators: NO, prostacyclin
Regulation of Inflammation and Immunity
IL-1, IL-6, chemokines
Adhesion molecules: VCAM-1, ICAM, E-selectin P-selectin
Histocompatibility antigens
Regulation of Cell Growth
Growth stimulators: PDGF, CSF, FGF
Growth inhibitors: heparin, TGF-β
Oxidation of LDL