WordNet

any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions

PrepTutorEJDIC

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

Amino acid residues that affect the basicity of the catalytic glutamate of the hydrolytic aldehyde dehydrogenases.

Muñoz-Clares RA1, González-Segura L2, Riveros-Rosas H3, Julián-Sánchez A3.
Chemico-biological interactions.Chem Biol Interact.2015 Jun 5;234:45-58. doi: 10.1016/j.cbi.2015.01.019. Epub 2015 Jan 21.
In the catalytic mechanism of hydrolytic aldehyde dehydrogenases (ALDHs) the role of Glu268 (mature human ALDH2 numbering) as a general base is of major relevance. Since Glu268 basicity depends on its protein environment, here we explore its interactions with other amino acid residues in the three d
PMID 25617482

Redox proteomics reveal stress responsive proteins linking peroxiredoxin-1 status in glioma to chemosensitivity and oxidative stress.

Poschmann G1, Grzendowski M2, Stefanski A3, Bruns E3, Meyer HE4, Stühler K3.
Biochimica et biophysica acta.Biochim Biophys Acta.2015 Jun;1854(6):624-31. doi: 10.1016/j.bbapap.2014.11.011. Epub 2014 Dec 4.
The combined deletion of chromosomal arms 1p and 19q has been described as a prognostic marker for oligodendroglial tumors. These tumors show a better response to chemotherapy and radiotherapy. Recently, we found a lower abundance of peroxiredoxin 1 (PRDX1) in oligodendroglial tumors with 1p/19q del
PMID 25484280

Deficient expression of aldehyde dehydrogenase 1A1 is consistent with increased sensitivity of Gorlin syndrome patients to radiation carcinogenesis.

Wright AT1, Magnaldo T, Sontag RL, Anderson LN, Sadler NC, Piehowski PD, Gache Y, Weber TJ.
Molecular carcinogenesis.Mol Carcinog.2015 Jun;54(6):473-84. doi: 10.1002/mc.22115. Epub 2013 Nov 27.
Human phenotypes that are highly susceptible to radiation carcinogenesis have been identified. Sensitive phenotypes often display robust regulation of molecular features that modify biological response, which can facilitate identification of the pathways/networks that contribute to pathophysiologica
PMID 24285572

Effect of length of molecular recognition moiety on enzymatic activity switching(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)

Oshiba Yuhei,Tamaki Takanori,Ohashi Hidenori [他],Hirakawa Hidehiko,Yamaguchi Satoshi,Nagamune Teruyuki,Yamaguchi Takeo
Journal of bioscience and bioengineering 116(4), 433-437, 2013-10
… 3mD was prepared by site-specific mutation to inhibit its enzymatic activity artificially, after which the derivative compounds were conjugated to the enzyme. … 3mD has one cysteine on its surface with a reactive thiol group that can react with compounds near the active site, where a conformational change will be induced after conjugation. …
NAID 110009675455

Ascorbic Acid and Thiol Antioxidants Suppress Spontaneous Mutagenesis in a Cu,Zn-superoxide Dismutase-deficient Mutant of Saccharomyces cerevisiae

Nagira Kohta,Tamura Sayaka,Kawano Shinji,Ikeda Shogo
Genes and Environment 35(4), 110-114, 2013
… Cu,Zn-superoxide dismutase (SOD1) is a critical enzyme in the cellular antioxidant system. … The results indicate that ascorbic acid and thiol antioxidants are able to efficiently protect cells against oxidative damage-induced mutagenesis. …
NAID 130004481207

Surface Binding Sites (SBSs), Mechanism and Regulation of Enzymes Degrading Amylopectin and α-Limit Dextrins

S. Møller Marie,Cockburn Darrell,W. Nielsen Jonas,M. Jensen Johanne,B. Vester-Christensen Malene,M. Nielsen Morten,M. Andersen Joakim,Wilkens Casper,Rannes Julie,Hägglund Per,Henriksen Anette,Abou Hachem Maher,Willemoës Martin,Svensson Birte
Journal of Applied Glycoscience 60(2), 101-109, 2013
… ii) The N-terminal domain of LD, the debranching enzyme in germinating seeds, shows distant structural similarity with domains including CBM21 present in other proteins and involved in various molecular interactions, but no binding site identity. … Based on the progress monitored by released free thiol groups from LDI and its failure to inhibit LD as elicited by trxh, the LDI inactivation is proposed to stem from loss of structural integrity due to reduction of all four disulfides. …
NAID 130004481028