関: thiethylperazine malate、thiethylperazine maleate

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/09 17:48:24」(JST)

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Thiethylperazine (Torecan) is an antiemetic of the phenothiazine class. Though it was never licensed or used as an antipsychotic, it may have such effects.

Thiethylperazine activates the transport protein ABCC1 that clears beta-amyloid from brains of mice. ^[1]

References

^ Science Daily (September 1, 2011). "Alzheimer Disease: Transport Protein ABCC1 Plays Key Role in Clearing Beta-Amyloid from Brains of Mice.". http://www.sciencedaily.com/releases/2011/09/110901134628.htm. Retrieved September 1, 2011.

Bourquin, J. P.; Schwarb, G.; Gamboni, G.; Rischer, R.; Ruesch, L.; Uldimann, S. G.; Theuss, U.; Schenke, E.; Renz, J.; Helv. Chim. Acta 1958, 41, 1072.

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English Journal

[Noncardiogenic pulmonary edema in the course of poisoning with clozapine, ketoprofen and thiethylperazine].

Majewska M1, Kołodziej M, Szponar J, Drelich G, Danielewicz P, Kostek H.
Przegla̧d lekarski.Przegl Lek.2012;69(8):618-20.
Pulmonary edema is a severe, potentially fatal clinical condition. It happens, when interstitial fluid is accumulating in the alveoli, impeding proper gas exchange. Typically we distinguish cardiogenic and noncardiogenic pulmonary edema. The article describes the case of severe pulmonary edema, whic
PMID 23243946

Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice.

Krohn M1, Lange C, Hofrichter J, Scheffler K, Stenzel J, Steffen J, Schumacher T, Brüning T, Plath AS, Alfen F, Schmidt A, Winter F, Rateitschak K, Wree A, Gsponer J, Walker LC, Pahnke J.
The Journal of clinical investigation.J Clin Invest.2011 Oct;121(10):3924-31. doi: 10.1172/JCI57867. Epub 2011 Sep 1.
In Alzheimer disease (AD), the intracerebral accumulation of amyloid-β (Aβ) peptides is a critical yet poorly understood process. Aβ clearance via the blood-brain barrier is reduced by approximately 30% in AD patients, but the underlying mechanisms remain elusive. ABC transporters have been impli
PMID 21881209

Enhancement of vancomycin activity by phenothiazines against vancomycin-resistant Enterococcus faecium in vitro.

Rahbar M1, Mehrgan H, Hadji-nejad S.
Basic & clinical pharmacology & toxicology.Basic Clin Pharmacol Toxicol.2010 Aug;107(2):676-9. doi: 10.1111/j.1742-7843.2010.00558.x. Epub 2010 Mar 28.
The antimicrobial and resistance-reversal activities of seven phenothiazine derivatives were evaluated against vancomycin-sensitive Enterococcus faecalis ATCC 29212, vancomycin resistant E. faecalis ATCC 51299 and ten vancomycin-resistant E. faecium strains originating from human infections. Minimum
PMID 20353486

Japanese Journal

表面電離検出ガスクロマトグラフィーによる血中フェノチアジン系薬物の高感度検出

服部秀樹,山本伸一,山田高路,鈴木修
1991-05-25
… The sensitivity of GC-SID was highest with trimeprazine and levomepromazine and lowest with thiethylperazine and thioproperazine containing sulfur residues in their structurs. …
NAID 120005313993

Thiethylperazine による oculogyric crisis

斉藤博
神眼 5, 79-83, 1988
NAID 50002760466

妊娠ダイコクネズミへのthiethylperazine-maleateによる胎仔における異所的癒合症

内山安男,間藤方雄
医学と生物学 91(3), p159-162, 1975-09
NAID 40000109189

「チエチルペラジン」

Thiethylperazine
Systematic (IUPAC) name
	2-(ethylthio)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy cat.	?
Legal status	?
Pharmacokinetic data
Protein binding	60%
Identifiers
CAS number	1420-55-9
ATC code	R06AD03
PubChem	CID 5440
DrugBank	DB00372
ChemSpider	5245
UNII	8ETK1WAF6R
KEGG	D02354
ChEBI	CHEBI:9544
ChEMBL	CHEMBL1378
Chemical data
Formula	C22H29N3S2
Mol. mass	399.618 g/mol
	SMILES S(c2cc1N(c3c(Sc1cc2)cccc3)CCCN4CCN(C)CC4)CC;
	InChI InChI=1S/C22H29N3S2/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24/h4-5,7-10,17H,3,6,11-16H2,1-2H3 ; Key:XCTYLCDETUVOIP-UHFFFAOYSA-N ;
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