telithromycin

出典: meddic

テリスロマイシン

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/10/05 04:54:25」(JST)

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英文文献

  • ClpP-Independent Function of ClpX Interferes with Telithromycin Resistance Conferred by Msr(A) in Staphylococcus aureus.
  • Vimberg V1, Lenart J1, Janata J1, Balikova Novotna G2.
  • Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2015 Jun;59(6):3611-4. doi: 10.1128/AAC.04367-14. Epub 2015 Mar 23.
  • The ABCF family protein Msr(A) confers high resistance to macrolides but only low resistance to ketolides in staphylococci. Mutations in conserved functional regions of ClpX as well as deletion of clpX significantly increased Msr(A)-mediated resistance to the ketolide antibiotic telithromycin. ClpX
  • PMID 25801573
  • Killing of Streptococcus pneumoniae by azithromycin, clarithromycin, erythromycin, telithromycin and gemifloxacin using drug minimum inhibitory concentrations and mutant prevention concentrations.
  • Blondeau JM1, Shebelski SD2, Hesje CK3.
  • International journal of antimicrobial agents.Int J Antimicrob Agents.2015 Jun;45(6):594-9. doi: 10.1016/j.ijantimicag.2014.12.034. Epub 2015 Feb 16.
  • Streptococcus pneumoniae continues to be a significant respiratory pathogen, and increasing antimicrobial resistance compromises the use of β-lactam and macrolide antibiotics. Bacterial eradication impacts clinical outcome, and bacterial loads at the site of infection may fluctuate. Killing of two
  • PMID 25752567
  • Novel gentamicin resistance genes in Campylobacter isolated from humans and retail meats in the USA.
  • Zhao S1, Mukherjee S2, Chen Y2, Li C2, Young S2, Warren M2, Abbott J2, Friedman S2, Kabera C2, Karlsson M3, McDermott PF2.
  • The Journal of antimicrobial chemotherapy.J Antimicrob Chemother.2015 May;70(5):1314-21. doi: 10.1093/jac/dkv001. Epub 2015 Feb 1.
  • OBJECTIVES: To understand the molecular epidemiology of gentamicin-resistant Campylobacter and investigate aminoglycoside resistance mechanisms.METHODS: One-hundred-and-fifty-one gentamicin-resistant Campylobacter isolates from humans (n = 38 Campylobacter jejuni; n = 41, Campylobacter coli)
  • PMID 25645207

和文文献

  • 呼吸器感染症の抗菌薬を用いた最適治療法の構築
  • 森本 一洋
  • YAKUGAKU ZASSHI 133(1), 81-92, 2013
  • … one was the distribution mechanisms of three macrolide and ketolide antibiotics, clarithromycin (CAM), azithromycin (AZM) and telithromycin (TEL) in plasma, ELF and AM, and the other was the efficient drug delivery to AM by pulmonary administration of fluoroquinolone antibiotic, a ciprofloxacin (CPFX) incorporated into liposomes (CPFX-liposome). …
  • NAID 130003361891
  • Azithromycin, clarithromycin and telithromycin inhibit MUC5AC induction by Chlamydophila pneumoniae in airway epithelial cells.
  • Morinaga Yoshitomo,Yanagihara Katsunori,Miyashita Naoyuki,Seki Masafumi,Izumikawa Koichi,Kakeya Hiroshi,Yamamoto Yoshihiro,Mukae Hiroshi,Yamada Yasuaki,Kohno Shigeru,Kamihira Shimeru
  • Pulmonary pharmacology & therapeutics 22(6), 580-586, 2009-12
  • … For inhibition study, cells were pretreated with azithromycin, clarithromycin and telithromycin before stimulation. … Clarithromycin and telithromycin, but not azithromycin, reduced NF-kappaB activation. … CONCLUSIONS: Clarithromycin and telithromycin were thought to interfere with the signal pathways between ERK and NF-kappaB. …
  • NAID 120001657488
  • 呼吸器感染症治療の最適化を目的としたテリスロマイシンの肺組織移行特性の評価
  • TOGAMI Kohei,CHONO Sumio,SEKI Toshinobu,MORIMOTO Kazuhiro
  • Drug metabolism and pharmacokinetics 24(5), 411-417, 2009-10-25
  • NAID 10025724522

関連リンク

Telithromycin is the first ketolide antibiotic to enter clinical use and is sold under the brand name of Ketek. It is used to treat community acquired pneumonia of mild to moderate severity. After significant controversy regarding safety and ...

関連画像

Telithromycin: An Oral Ketolide for Telithromycin.svgTelithromycin (800 mg daily for 5 days)Rodrigo Andrade | Department of Chemistry Telithromycin (9782)TELITHROMYCIN Drug and Prescription


★リンクテーブル★
リンク元マクロライド系抗菌薬」「テリスロマイシン

マクロライド系抗菌薬」

  [★]

macrolide antibiotic macrolide antibiotics, macrolides, MLs
マクロライド系抗生物質 ←厳密には違うが、多くの人が間違って使っている
抗菌薬

特徴

  • 抗菌スペクトルが広い
  • 静菌的に作用
  • 大きな環状構造を有する。14員環-16員環
  • タンパク質合成阻害薬
  • 抗生物質としての作用の他に、抗炎症作用を有するらしい
炎症の抑制 ex.びまん性汎細気管支炎

構造

  • http://www.sigmaaldrich.com/life-science/life-science-catalog/product-catalog.html?TablePage=14572877
  • Macrolide antibiotics contain a many-membered lactone ring (14-membered rings for erythromycin and clarithromycin and a 15-membered ring for azithromycin) to which are attached one or more deoxy sugars. Clarithromycin differs from erythromycin only by methylation of the hydroxyl group at the 6 position, and azithromycin differs by the addition of a methyl-substituted nitrogen atom into the lactone ring. These structural modifications improve acid stability and tissue penetration and broaden the spectrum of activity.(GOO. chapter 46)

作用機序

  • inhibit bacterial protein synthesis by reacting with the 50s ribosomal subunit and preventing the release of the uncharged tRNA.

薬理作用

動態

  • 経口で吸収される

抗菌スペクトル

  • ペニシリンより広い抗菌スペクトル
  • グラム陽性球菌、グラム陰性球菌、グラム陰性桿菌、スピロヘータ、一部のリケッチア、ウイルス

適応

  • マイコプラズマ肺炎、クラミジア感染症、カンピロバクター腸炎、レジオネラ症
  • びまん性汎細気管支炎:14員環マクロライドのみ
  • URIs, pneumonias, STD

注意

禁忌

副作用

悪心、嘔吐、消化器の蠕動を促進
  • 薬物相互作用
テオフィリン
喘息の治療薬。CYP3A4で代謝される。中毒域と治療域がちかいので注意する

マクロライド系抗菌薬

14員環

15員環

16員環

14員環 (ケトライド系抗菌薬)

有効性 (SMB.147)

○:殺菌的、△静菌的




テリスロマイシン」

  [★]

telithromycin
抗菌薬





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