WordNet

small room in which a monk or nun lives (同)cubicle
a device that delivers an electric current as the result of a chemical reaction (同)electric cell
a room where a prisoner is kept (同)jail cell, prison cell
(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
any small compartment; "the cells of a honeycomb"
a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
a mass of fungal tissue that has spore-bearing structures embedded in it or on it
the dense colorless framework of a chloroplast
the supporting tissue of an organ (as opposed to parenchyma)

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(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/12 20:18:36」(JST)

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Stromal cells are connective tissue cells of any organ, for example in the uterine mucosa (endometrium), prostate, bone marrow, and the ovary. They are cells that support the function of the parenchymal cells of that organ. Fibroblasts and pericytes are among the most common types of stromal cells.

The interaction between stromal cells and tumor cells is known to play a major role in cancer growth and progression.^[1] In addition, by regulating local cytokine networks (e.g. M-CSF,^[2] LIF^[3]), bone marrow stromal cells have been described to be involved in human haematopoiesis and inflammatory processes.

Stromal cells (in the dermis layer) adjacent to the epidermis (the very top layer of the skin) release growth factors that promote cell division. This keeps the epidermis regenerating from the bottom while the top layer of cells on the epidermis are constantly being "sloughed" off of the body. Certain types of skin cancers (basal cell carcinomas) cannot spread throughout the body because the cancer cells require nearby stromal cells to continue their division. The loss of these stromal growth factors when the cancer moves throughout the body prevents the cancer from invading other organs.

Stroma is made up of the non-malignant host cells. Stroma provides an extracellular matrix on which tumors can grow.

Stroma (disambiguation)
Stroma of ovary

References

^ Wiseman BS, Werb Z (May 2002). "Stromal effects on mammary gland development and breast cancer" (PDF). Science 296 (5570): 1046–9. doi:10.1126/science.1067431. PMC 2788989. PMID 12004111.
^ Fixe, Philippe (1997). "Spontaneous and inducible production of macrophage colony-stimulating factor by human bone marrow stromal cells". European Cytokine Network 8: 91–5. PMID 9110154.
^ LORGEOT, Valérie (28 February 1997). "SPONTANEOUS AND INDUCIBLE PRODUCTION OF LEUKAEMIA INHIBITORY FACTOR BY HUMAN BONE MARROW STROMAL CELLS". Cytokine 9 (10): 754–758. doi:10.1006/cyto.1997.0225. Retrieved 18 April 2002.

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1. 卵巣の性索間質腫瘍：顆粒膜-間質細胞腫瘍 sex cord stromal tumors of the ovary granulosa stromal cell tumors
2. 卵巣の性索間質腫瘍：セルトリ・間質細胞腫瘍 sex cord stromal tumors of the ovary sertoli stromal cell tumors
3. GISTを含む消化管間葉系腫瘍の疫学、分類、臨床像、予後の特徴、および診断方法 epidemiology classification clinical presentation prognostic features and diagnostic work up of gastrointestinal mesenchymal neoplasms including gist
4. T細胞受容体シグナル伝達 t cell receptor signaling
5. 原発性皮膚大細胞型B細胞性リンパ腫、下肢型 primary cutaneous large b cell lymphoma leg type

English Journal

Transcriptomic Analyses of Adipocyte Differentiation From Human Mesenchymal Stromal-Cells (MSC).

Casado-Díaz A1, Anter J2, Müller S3, Winter P3, Quesada-Gómez JM1, Dorado G4.
Journal of cellular physiology.J Cell Physiol.2017 Apr;232(4):771-784. doi: 10.1002/jcp.25472. Epub 2016 Jul 12.
Adipogenesis is a physiological process required for fat-tissue development, mainly involved in regulating the organism energetic-state. Abnormal distribution-changes and dysfunctions in such tissue are associated to different pathologies. Adipocytes are generated from progenitor cells, via a comple
PMID 27349923

Downregulation of DNA methyltransferase 3 alpha promotes cell proliferation and invasion of ectopic endometrial stromal cells in adenomyosis.

Zou Y1, Liu FY1, Wang LQ2, Guo JB2, Yang BC3, Wan XD3, Wang F1, He M4, Huang OP5.
Gene.Gene.2017 Mar 10;604:41-47. doi: 10.1016/j.gene.2016.12.011. Epub 2016 Dec 14.
Adenomyosis is a common benign gynecological condition in female reproductive tract and the detailed molecular etiology remains largely elusive. Previous studies implicated that deregulated expression of DNA (cytosine-5)-methyltransferase 3A (DNMT3A), a de novo DNA methyltransferase, might be involv
PMID 27986572

Bone marrow stromal cells promote neuroplasticity of cerebral ischemic rats via a phosphorylated CRMP2-mediated mechanism.

He X1, Jiang L1, Dan QQ1, Lv Q1, Hu Y1, Liu J2, Wang SF3, Wang TH4.
Behavioural brain research.Behav Brain Res.2017 Mar 1;320:494-503. doi: 10.1016/j.bbr.2016.10.027. Epub 2016 Oct 17.
Collapsin response mediator protein 2 (CRMP2), an important protein involved in axonal growth and the maintenance of neuronal membrane integrity, has proved to be altered in nervous system diseases. This study was aimed to investigate the role of CRMP2 in bone marrow stromal cells (BMSCs) treating r
PMID 27765673

Japanese Journal

がん保険における"ICD-10約款"の脆弱(ぜいじゃく)性

中尾修一
日本保険医学会誌 112(3), 211-231, 2014-09-24
がん保険の約款上の支払事由の根拠規定として,『ICD-10(疾病,傷害および死因統計分類提要)』に加えて『ICD-O-3(国際疾病分類腫瘍学第3版)』を明示する約款を採用する会社が急増している。その背景には次の要因が考えられる。(1)"ICD-10 only約款"と『ICD-O-2(腫瘍学-第2版)』との関係再認識 (2)GIST等の新概念腫瘍への対応 (3)"Dコード四疾患(骨髄異形成症候群 …
NAID 110009857666

An exploratory clinical trial for idiopathic osteonecrosis of femoral head by cultured autologous multipotent mesenchymal stromal cells augmented with vascularized bone grafts.

Aoyama Tomoki,Goto Koji,Kakinoki Ryosuke,Ikeguchi Ryosuke,Ueda Michiko,Kasai Yasunari,Maekawa Taira,Tada Harue,Teramukai Satoshi,Nakamura Takashi,Toguchida Junya
Tissue engineering. Part B, Reviews 20(4), 233-242, 2014-08-05
… Transplantation of multipotent mesenchymal stromal cells (MSCs) is a promising tool for regenerating the musculoskeletal system. … Although the efficacy of cell transplantation was still to be determined, all procedures were successfully performed and some young patients with extensive necrotic lesions with pain demonstrated good bone regeneration with amelioration of symptoms. …
NAID 120005468373

An inflammatory myofibroblastic tumor exhibiting immunoreactivity to KIT: a case report focusing on a diagnostic pitfall.

Kataoka Tatsuki R,Yamashita Nobuhiro,Furuhata Ayako,Hirata Masahiro,Ishida Takaki,Nakamura Ichiro,Hirota Seiichi,Haga Hironori,Katsuyama Eiji
World journal of surgical oncology 12, 2014-06-18
… Inflammatory myofibroblastic tumors (IMTs) and gastrointestinal stromal tumors (GISTs) are both spindle cell tumors, and occur rarely in the wall of the urinary bladder. … Here, we describe a case of a spindle cell tumor in the wall of the urinary bladder. … Therefore, IMTs should be included in the differential diagnosis of spindle cell tumors, even those that are KIT-positive. …
NAID 120005458277

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★リンクテーブル★

リンク元	「間質細胞」「ストロマ細胞」「ストローマ細胞」
拡張検索	「stromal cell-derived growth factor」「stromal cell-derived factor」「stromal cell-derived factor-1」
関連記事	「stromal」「stroma」「cell」