sterol regulatory element binding protein 1

出典: meddic

ステロール調節エレメント結合タンパク質1ステロール調節配列結合タンパク質1ステロール調節因子結合タンパク質1ステロール調節領域結合タンパク質1

SREBP1

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英文文献

  • The immunosuppressive agents rapamycin, cyclosporin A and tacrolimus increase lipolysis, inhibit lipid storage and alter expression of genes involved in lipid metabolism in human adipose tissue.
  • Pereira MJ, Palming J, Rizell M, Aureliano M, Carvalho E, Svensson MK, Eriksson JW.SourceThe Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at University of Gothenburg, 413 45 Gothenburg, Sweden; Centre for Marine Sciences (CCMar), DCBB/FCT, University of Algarve, 8005 139 Faro, Portugal; Center for Neuroscience and Cell Biology, University of Coimbra, 3000 Coimbra, Portugal. Electronic address: maria.pereira@gu.se.
  • Molecular and cellular endocrinology.Mol Cell Endocrinol.2013 Jan 30;365(2):260-9. doi: 10.1016/j.mce.2012.10.030. Epub 2012 Nov 15.
  • Cyclosporin A (CsA), tacrolimus and rapamycin are immunosuppressive agents (IAs) associated with insulin resistance and dyslipidemia, although their molecular effects on lipid metabolism in adipose tissue are unknown. We explored IAs effects on lipolysis, lipid storage and expression of genes involv
  • PMID 23160140
  • Testosterone deficiency induces markedly decreased serum triglycerides, increased small dense LDL, and hepatic steatosis mediated by dysregulation of lipid assembly and secretion in mice fed a high-fat diet.
  • Senmaru T, Fukui M, Okada H, Mineoka Y, Yamazaki M, Tsujikawa M, Hasegawa G, Kitawaki J, Obayashi H, Nakamura N.SourceDepartment of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
  • Metabolism: clinical and experimental.Metabolism.2013 Jan 16. pii: S0026-0495(12)00460-X. doi: 10.1016/j.metabol.2012.12.007. [Epub ahead of print]
  • OBJECTIVE: Although low serum testosterone (T) is associated with metabolic disorders, the mechanism of this association is unclear. The objective of the present study was to investigate the combined effects of T deficiency and a high-fat diet (HFD) on hepatic lipid homeostasis in mice.MATERIALS/MET
  • PMID 23332447
  • hnRNP A1 mediates the activation of the IRES-dependent SREBP-1a mRNA translation in response to endoplasmic reticulum stress.
  • Damiano F, Rochira A, Tocci R, Alemanno S, Gnoni A, Siculella L.Source*Laboratory of Biochemistry and Molecular Biology, Department of Biological and Environmental Sciences and Technologies, University of Salento, Via Prov. le Lecce-Monteroni, Lecce 73100, Italy.
  • The Biochemical journal.Biochem J.2013 Jan 15;449(2):543-53. doi: 10.1042/BJ20120906.
  • A growing amount of evidence suggests the involvement of ER (endoplasmic reticulum) stress in lipid metabolism and in the development of some liver diseases such as steatosis. The transcription factor SREBP-1 (sterol-regulatory-element-binding protein 1) modulates the expression of several enzymes i
  • PMID 23106379

和文文献

  • CREB-binding protein transcription activation domain for enhanced transgene expression by a positive feedback system
  • Kanda Genki,Ochiai Hiroshi,Harashima Hideyoshi,Kamiya Hiroyuki
  • Journal of Biotechnology 157(1), 7-11, 2012-01
  • … The positive feedback system using a fusion protein of the sequence-specific DNA binding domain of yeast GAL4 and the transcription activation domain of herpes simplex virus VP16 (GAL4-VP16), in which GAL4-VP16 promotes its own expression as well as that of a reporter gene product, is useful for efficient transgene expression from plasmid DNA. …
  • NAID 120003811532
  • Inhibition of Ubiquitin Ligase F-box and WD Repeat Domain-containing 7α (Fbw7α) Causes Hepatosteatosis through Krüppel-like Factor 5 (KLF5)/Peroxisome Proliferator-activated Receptor γ2 (PPARγ2) Pathway but Not SREBP-1c Protein in Mice
  • Kumadaki Shin,Karasawa Tadayoshi,Matsuzaka Takashi,Ema Masatsugu,Nakagawa Yoshimi,Nakakuki Masanori,Saito Ryo,Yahagi Naoya,Iwasaki Hitoshi,Sone Hirohito,Takekoshi Kazuhiro,Yatoh Shigeru,Kobayashi Kazuto,Takahashi Akimitsu,Suzuki Hiroaki,Takahashi Satoru,Yamada Nobuhiro,Shimano Hitoshi,松坂 賢,依馬 正次,中川 嘉,矢作 直也,岩﨑 仁,曽根 博仁,竹越 一博,矢藤 繁,小林 和人,高橋 昭光,鈴木 浩明,高橋 智,山田 信博,島野 仁
  • The journal of biological chemistry 286(47), 40835-40846, 2011-11
  • … F-box and WD repeat domain-containing 7α (Fbw7α) is the substrate recognition component of a ubiquitin ligase that controls the degradation of factors involved in cellular growth, including c-Myc, cyclin E, and c-Jun. In addition, Fbw7α degrades the nuclear form of sterol regulatory element-binding protein (SREBP)-1a, a global regulator of lipid synthesis, particularly during mitosis in cultured cells. …
  • NAID 120003674222

関連リンク

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory ...
"Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells." Shimomura I., Shimano H., Horton J.D., Goldstein J.L., Brown M.S. J. Clin [] [] [] ...

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★リンクテーブル★
リンク元ステロール調節エレメント結合タンパク質1」「ステロール調節因子結合タンパク質1」「ステロール調節配列結合タンパク質1」「ステロール調節領域結合タンパク質1」「SREBP1
関連記事element」「binding」「regulator」「protein」「sterol

ステロール調節エレメント結合タンパク質1」

  [★]

sterol regulatory element binding protein 1SREBP1
ステロール調節配列結合タンパク質1ステロール調節因子結合タンパク質1ステロール調節領域結合タンパク質1


ステロール調節因子結合タンパク質1」

  [★]

sterol regulatory element binding protein 1
ステロール調節エレメント結合タンパク質1ステロール調節配列結合タンパク質1ステロール調節領域結合タンパク質1


ステロール調節配列結合タンパク質1」

  [★]

sterol regulatory element binding protein 1
ステロール調節エレメント結合タンパク質1ステロール調節因子結合タンパク質1ステロール調節領域結合タンパク質1


ステロール調節領域結合タンパク質1」

  [★]

sterol regulatory element binding protein 1
ステロール調節エレメント結合タンパク質1ステロール調節配列結合タンパク質1ステロール調節因子結合タンパク質1


SREBP1」

  [★]

sterol regulatory element binding protein 1


element」

  [★]

  • n.
  • 要素、成分、素。(構成)分子。(科学)元素、(数)(集合の)要素、元素、素。(行列の)要素、成分。(図形を火tが千都来る)要素。(文法の)要素
  • (電子)素子、(光学)素子
basalbasesbasicbasiscomponentcompositionconstituentelementaryfactorfundamentalsingredientmoiety

WordNet   license wordnet

「a straight line that generates a cylinder or cone」

WordNet   license wordnet

「one of four substances thought in ancient and medieval cosmology to constitute the physical universe; "the alchemists believed that there were four elements"」

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「the situation in which you are happiest and most effective; "in your element"」

WordNet   license wordnet

「the most favorable environment for a plant or animal; "water is the element of fishes"」

PrepTutorEJDIC   license prepejdic

「〈C〉(物質を構成する)元素 / 〈C〉《修飾語[句]を伴って》(…の)(基本的な)『要素』,『成分』;《しばしば複数形で》構成分子 / 〈C〉(生物に固有の)生息場所,環境;(人の)適所,本領 / 〈C〉《古》四大(しだい)[元素](自然界の基本的構成要素と考えられていた地(earth)・水(water)・風(air)・火(fire)の4大要素の一つ) / 《the elements》(雨・風・雪などの)自然力・風雨,(特に)悪天候 / 《the elements》(学問の)原理,初歩,概論」

binding」

  [★]

  • n.
  • adj.
  • 結合性の
affinityassociatebindbondbondingcombineconjoinconjugateconjugationconjunctionconnectconnectionconnectiveconnectivitycoupledockengageengagementjoinligatelinkagesymphysialsymphysicunion

WordNet   license wordnet

「executed with proper legal authority; "a binding contract"」

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「the protective covering on the front, back, and spine of a book; "the book had a leather binding"」
book binding, cover, back

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「strip sewn over or along an edge for reinforcement or decoration」

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「the capacity to attract and hold something」

PrepTutorEJDIC   license prepejdic

「義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料」


regulator」

  [★]

  • n.
regulatory factor

WordNet   license wordnet

「any of various controls or devices for regulating or controlling fluid flow, pressure, temperature, etc.」

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「an official responsible for control and supervision of a particular activity or area of public interest」

PrepTutorEJDIC   license prepejdic

「取り締まり人;調整者 / 調整装置」


protein」

  [★] 蛋白質

WordNet   license wordnet

「any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"」

PrepTutorEJDIC   license prepejdic

「蛋白(たんばく)質」


sterol」

  [★]

ステロール

WordNet   license wordnet

「any of a group of natural steroid alcohols derived from plants or animals; they are waxy insoluble substances」
steroid alcohol




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