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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/15 21:23:44」(JST)

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Sterol regulatory element-binding transcription factor 1 (SREBF1) also known as sterol regulatory element-binding protein 1 (SREBP-1) is a protein that in humans is encoded by the SREBF1 gene.^[1]^[2]

This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.^[3] The isoforms are SREBP-1a and -1c (ADD-1).

Function

The proteins encoded by this gene are transcription factors that bind to a sequence in the promoter of different genes, called sterol regulatory element-1 (SRE1). This element is a decamer flanking the LDL receptor gene and other genes involved in, for instance, sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family.

SREBP-1c regulates genes required for glucose metabolism and fatty acid and lipid production and its expression is regulated by insulin.^[4] SREBP-1a regulates genes related to lipid and cholesterol production and its activity is regulated by sterol levels in the cell.^[5]

Interactions

SREBF1 has been shown to interact with TWIST2,^[6] CREB-binding protein,^[7] DAX1^[8] and LMNA.^[9]

References

^ Yokoyama C, Wang X, Briggs MR, Admon A, Wu J, Hua X, Goldstein JL, Brown MS (November 1993). "SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene". Cell 75 (1): 187–97. doi:10.1016/S0092-8674(05)80095-9. PMID 8402897.
^ Hua X, Wu J, Goldstein JL, Brown MS, Hobbs HH (June 1995). "Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13". Genomics 25 (3): 667–673. doi:10.1016/0888-7543(95)80009-B. PMID 7759101.
^ "Entrez Gene: SREBF1 sterol regulatory element binding transcription factor 1".
^ Ferré P, Foufelle F (October 2010). "Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c". Diabetes Obes Metab 12 (Suppl 2): 83–92. doi:10.1111/j.1463-1326.2010.01275.x. PMID 21029304.
^ Eberlé D, Hegarty B, Bossard P, Ferré P, Foufelle F (November 2004). "SREBP transcription factors: master regulators of lipid homeostasis". Biochimie 86 (11): 839–48. doi:10.1016/j.biochi.2004.09.018. PMID 15589694.
^ Lee, Yun Sok; Lee Hyoung Ho; Park Jiyoung; Yoo Eung Jae; Glackin Carlotta A; Choi Young Il; Jeon Sung Ho; Seong Rho Hyun; Park Sang Dai; Kim Jae Bum (Dec 2003). "Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c". Nucleic Acids Res. (England) 31 (24): 7165–7174. doi:10.1093/nar/gkg934. PMC 291873. PMID 14654692.
^ Oliner, J D; Andresen J M; Hansen S K; Zhou S; Tjian R (November 1996). "SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein". Genes Dev. (UNITED STATES) 10 (22): 2903–2911. doi:10.1101/gad.10.22.2903. ISSN 0890-9369. PMID 8918891.
^ Lopez, D; Shea-Eaton W; Sanchez M D; McLean M P (Dec 2001). "DAX-1 represses the high-density lipoprotein receptor through interaction with positive regulators sterol regulatory element-binding protein-1a and steroidogenic factor-1". Endocrinology (United States) 142 (12): 5097–5106. doi:10.1210/en.142.12.5097. ISSN 0013-7227. PMID 11713202.
^ Lloyd, David J; Trembath Richard C; Shackleton Sue (April 2002). "A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies". Hum. Mol. Genet. (England) 11 (7): 769–777. doi:10.1093/hmg/11.7.769. ISSN 0964-6906. PMID 11929849.

External links

SREBF1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
FactorBook SREBP1

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

English Journal

Hexosamine Biosynthesis Impairs Insulin Action via a Cholesterolgenic Response.

Penque BA, Hoggatt AM, Herring BP, Elmendorf JS.SourcePhD, Department of Cellular and Integrative Physiology, Indiana University School of Medicine, VanNuys Medical Science Building Room 308A, Indianapolis, Indiana 46202. jelmendo@iupui.edu.
Molecular endocrinology (Baltimore, Md.).Mol Endocrinol.2013 Mar;27(3):536-47. doi: 10.1210/me.2012-1213. Epub 2013 Jan 11.
Plasma membrane cholesterol accumulation has been implicated in cellular insulin resistance. Given the role of the hexosamine biosynthesis pathway (HBP) as a sensor of nutrient excess, coupled to its involvement in the development of insulin resistance, we delineated whether excess glucose flux thro
PMID 23315940

MicroRNA-27a regulates lipid metabolism and inhibits hepatitis C virus replication in human hepatoma cells.

Shirasaki T, Honda M, Shimakami T, Horii R, Yamashita T, Sakai Y, Sakai A, Okada H, Watanabe R, Murakami S, Yi M, Lemon SM, Kaneko S.SourceDepartment of Gastroenterology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
Journal of virology.J Virol.2013 Feb 28. [Epub ahead of print]
Replication and infectivity of the lipotropic hepatitis C virus (HCV) is regulated by cellular lipid status. Among differentially expressed micro (mi)RNAs, we found that miR-27a was preferentially expressed in HCV-infected liver compared with hepatitis B virus (HBV)-infected liver. Gene expression p
PMID 23449803

Japanese Journal

Inhibition of Ubiquitin Ligase F-box and WD Repeat Domain-containing 7α (Fbw7α) Causes Hepatosteatosis through Krüppel-like Factor 5 (KLF5)/Peroxisome Proliferator-activated Receptor γ2 (PPARγ2) Pathway but Not SREBP-1c Protein in Mice

Kumadaki Shin,Karasawa Tadayoshi,Matsuzaka Takashi,Ema Masatsugu,Nakagawa Yoshimi,Nakakuki Masanori,Saito Ryo,Yahagi Naoya,Iwasaki Hitoshi,Sone Hirohito,Takekoshi Kazuhiro,Yatoh Shigeru,Kobayashi Kazuto,Takahashi Akimitsu,Suzuki Hiroaki,Takahashi Satoru,Yamada Nobuhiro,Shimano Hitoshi,松坂賢,依馬正次,中川嘉,矢作直也,岩﨑仁,曽根博仁,竹越一博,矢藤繁,小林和人,高橋昭光,鈴木浩明,高橋智,山田信博,島野仁
The journal of biological chemistry 286(47), 40835-40846, 2011-11
F-box and WD repeat domain-containing 7α (Fbw7α) is the substrate recognition component of a ubiquitin ligase that controls the degradation of factors involved in cellular growth, including c-Myc, cyc …
NAID 120003674222

Oleuropein and hydroxytyrosol inhibit adipocyte differentiation in 3 T3-L1 cells

Drira Riadh,Shu Chen,Sakamoto Kazuichi,坂本和一
Life sciences 89(19-20), 708-716, 2011-11
AimsOleuropein and hydroxytyrosol, which are antioxidant molecules found in olive leaves and oil, have been reported to exert several biochemical and pharmacological effects. These polyphenols are abl …
NAID 120003551304

Related Pictures

Protéine Srebp1; Facteur de receptor-dependent activation of SREBP1 Sterol Regulatory Element Binding Protein Modal title stage hypothetical model of Insig1/SREBP1 SREBP (Sterol Regulatory Element Binding Layers of SREBP1/2 by SIRT6: Cell Reports

★リンクテーブル★

リンク元	「sterol regulatory element binding protein 1」「ステロール調節エレメント結合タンパク質1」
関連記事	「SREBP」

「sterol regulatory element binding protein 1」

Sterol regulatory element binding transcription factor 1
	; PDB rendering based on 1am9.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1AM9
Identifiers
Symbols	SREBF1 ; SREBP-1c; SREBP1; bHLHd1
External IDs	OMIM: 184756 MGI: 107606 HomoloGene: 3079 GeneCards: SREBF1 Gene
Gene ontology
Molecular function	• DNA binding; • chromatin binding; • sequence-specific DNA binding transcription factor activity; • protein binding; • protein kinase binding; • protein complex binding; • sterol response element binding; • sequence-specific DNA binding; • protein dimerization activity;
Cellular component	• Golgi membrane; • nucleus; • nuclear envelope; • nucleoplasm; • cytoplasm; • endoplasmic reticulum; • endoplasmic reticulum membrane; • cytosol; • ER to Golgi transport vesicle membrane; • integral component of membrane; • protein complex;
Biological process	• negative regulation of transcription from RNA polymerase II promoter; • regulation of heart rate by chemical signal; • transcription, DNA-templated; • regulation of transcription from RNA polymerase II promoter; • lipid metabolic process; • aging; • cholesterol metabolic process; • insulin receptor signaling pathway; • lipid biosynthetic process; • cellular response to starvation; • response to glucose; • positive regulation of triglyceride biosynthetic process; • regulation of fatty acid metabolic process; • lung development; • positive regulation of histone deacetylation; • response to food; • response to retinoic acid; • response to progesterone; • response to glucagon; • response to drug; • cellular lipid metabolic process; • small molecule metabolic process; • positive regulation of cholesterol biosynthetic process; • positive regulation of transcription from RNA polymerase II promoter; • negative regulation of insulin secretion; • response to cAMP; • cellular response to fatty acid;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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