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Micrograph showing squamous metaplasia (centre of image) in an atypical polypoid adenomyoma. H&E stain.

Squamous metaplasia refers to benign non-cancerous change (metaplasia) of (non-squamous) surfacing lining cells (epithelium) to a squamous morphology.

Location

Common sites for squamous metaplasia include the bladder and cervix. Smokers often exhibit squamous metaplasia in the linings of their airways. These changes don't signify a specific disease, but rather usually represent the body's response to stress or irritation. Vitamin A deficiency or overdose can also lead to squamous metaplasia.^[1]

Uterine cervix

In regard to the cervix, squamous metaplasia can sometimes be found in the endocervix, as it is composed of simple columnar epithelium, whereas the ectocervix is composed of stratified squamous non-keratinized epithelium .^[2]

Significance

Squamous metaplasia may be seen in the context of benign lesions (e.g. atypical polypoid adenomyoma), chronic irritation or cancer (e.g. endometrioid endometrial carcinoma).

References

^ Goralczyk, R (2009). "ß-Carotene and Lung Cancer in Smokers: Review of Hypotheses and Status of Research". Nutrition and Cancer 61 (6): 767–774. doi:10.1080/01635580903285155. PMID 20155614.
^ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; & Mitchell, Richard N. (2007) Robbins Basic Pathology (8th ed.). Saunders Elsevier. pp. 716-720 ISBN 978-1-4160-2973-1

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UpToDate Contents

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1. Cervical and vaginal cytology: Interpretation of results (Pap test report)
2. 子宮頚部細胞診：異型扁平上皮細胞（ASC-USおよびASC-H）の評価 cervical cytology evaluation of atypical squamous cells asc us and asc h
3. 頭頸部腫瘍の病理 pathology of head and neck neoplasms
4. 非尿路上皮膀胱癌 non urothelial bladder cancer
5. 肺悪性腫瘍の病理 pathology of lung malignancies

English Journal

Immunohistochemical study of metaplastic carcinoma and central acellular carcinoma of the breast: central acellular carcinoma is related to metaplastic carcinoma.

Yamaguchi R, Tanaka M, Kondo K, Yokoyama T, Maeda I, Tsuchiya S, Yamaguchi M, Takahashi R, Ogata Y, Abe H, Akiba J, Nakashima O, Kage M, Yano H.SourceDepartment of Pathology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan. rin@med.kurume-u.ac.jp
Medical molecular morphology.Med Mol Morphol.2012 Dec;45(1):14-21. Epub 2012 Mar 20.
Metaplastic breast cancers (MBCs) [spindle cell carcinoma (SpCC), squamous cell carcinoma (SCC), and matrix-producing carcinoma (MPC)] and invasive carcinomas with central acellular zones (CACs) were analyzed with respect to biological potential by immunohistochemical analyses. Specimens from 40 pat
PMID 22431179