spiradoline

出典: meddic


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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/07/30 21:36:01」(JST)

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英文文献

  • Role of mu, delta and kappa opioid receptors in ethanol-reinforced operant responding in infant rats.
  • Miranda-Morales RS, Spear NE, Nizhnikov ME, Molina JC, Abate P.SourceInstituto de Investigación Médica M. y M. Ferreyra (INIMEC-CONICET), 5016 Córdoba, Argentina.
  • Behavioural brain research.Behav Brain Res.2012 Oct 1;234(2):267-77. doi: 10.1016/j.bbr.2012.07.002. Epub 2012 Jul 10.
  • We recently observed that naloxone, a non-specific opioid antagonist, attenuated operant responding to ethanol in infant rats. Through the use of an operant conditioning technique, we aimed to analyze the specific participation of mu, delta, and kappa opioid receptors on ethanol reinforcement during
  • PMID 22789403
  • Early role of the κ opioid receptor in ethanol-induced reinforcement.
  • Pautassi RM, Nizhnikov ME, Acevedo MB, Spear NE.SourceInstituto de Investigación Médica M. y M. Ferreyra (INIMEC-CONICET), Córdoba, C.P 5000, Argentina. rpautassi@gmail.com
  • Physiology & behavior.Physiol Behav.2012 Mar 20;105(5):1231-41. doi: 10.1016/j.physbeh.2012.01.003. Epub 2012 Jan 11.
  • Effects of early ethanol exposure on later ethanol intake emphasize the importance of understanding the neurobiology of ethanol-induced reinforcement early in life. Infant rats exhibit ethanol-induced appetitive conditioning and ethanol-induced locomotor activation, which have been linked in theory
  • PMID 22261437

和文文献

  • Effects of Spiradoline Mesylate, a Selective κ-Opioid-Receptor Agonist, on the Central Dopamine System with Relation to Mouse Locomotor Activity and Analgesia
  • Kunihara Mineo,Ohyama Miwako,Nakano Miyuki
  • The Japanese Journal of Pharmacology 62(3), 223-230, 1993
  • … Neurochemical and behavioral investigations were made to assess the role of central dopaminergic systems in mouse locomotor activity and analgesia by spiradoline mesylate. … Analgesic activities of the κ-opioid-receptor agonists spiradoline and U-50488H were not altered by haloperidol or L-dopa, whereas morphine analgesia was enhanced by haloperidol but attenuated by L-dopa. …
  • NAID 130000840337

関連画像

62066 spiradoline is illustrated in the Enadoline synthesis.pngSpiradoline synthesis.pngFIGURE 4. Switching the behavioural taste Spiradoline synthesis: Lester J. Kaplan Spiradoline.png


★リンクテーブル★
リンク元オピオイド

オピオイド」

  [★]

opioid
類麻薬
オピオイド受容体


作用

縮瞳

  • モルフィンと多くのμ,κアゴニストは瞳孔の縮小を引き起こす。これは瞳孔を支配する副交感神経の興奮による。μアゴニストを中毒量投与すると縮瞳し、pinpoints pupupilsはpathognomonicである。(GOO.559)

オピオイドとオピオイド類似物質の作用

GOO.552
Drugs  RECEPTOR TYPES
μ受容体 δ受容体 κ受容体
morphine +++  
methadone +++    
etorphine +++ +++ +++
levorphanol +++    
fentanyl +++    
sufentanil +++
DAMGO +++    
butorphanol P   +++
buprenorphine P   ーー
naloxone ーーー ーー
naltrexone ーーー ーーー
CTOP ーーー    
diprenorphine ーーー ーー ーーー
β-funaltrexamine ーーー ++
naloxonazine ーーー
nalorphine ーーー  
pentazocine P   ++
nalbuphine ーー   ++
naloxone benzoylhydrazone ーーー
bremazocine +++ ++ +++
ethylketocyclazocine P +++
U50,488     +++
U69,593     +++
spiradoline   +++
nor-Binaltorphimine ーーー
naltrindole ーーー
DPDPE   ++  
[[[[D-Ala2,Glu4]deltorphin]]   ++  
       
DSLET ++  
endogenous Peptides       
met-enkephalin ++ +++  
leu-enkephalin ++ +++  
β-endorphin +++ +++  
dynorphin A ++   +++
dynorphin B +++
α-neoendorphin +++
+アゴニスト ーアンタゴニスト P partial agonist




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