spinal neoplasm

脊椎腫瘍、脊椎新生物

WordNet

1. work natural fibers into a thread; "spin silk"
2. prolong or extend; "spin out a visit" (同)spin out
3. the act of rotating rapidly; "he gave the crank a spin"; "it broke off after much twisting" (同)twirl, twist, twisting, whirl
4. a distinctive interpretation (especially as used by politicians to sway public opinion); "the campaign put a favorable spin on the story"
5. a short drive in a car; "he took the new car for a spin"
6. a swift whirling motion (usually of a missile)
7. revolve quickly and repeatedly around ones own axis; "The dervishes whirl around and around without getting dizzy" (同)spin around, whirl, reel, gyrate
8. form a web by making a thread; "spiders spin a fine web"
9. make up a story; "spin a yarn"
10. stream in jets, of liquids; "The creek spun its course through the woods"
11. twist and turn so as to give an intended interpretation; "The Presidents spokesmen had to spin the story to make it less embarrassing"
12. of or relating to the spine or spinal cord; "spinal cord"; "spinal injury"

PrepTutorEJDIC

1. (羊毛などから)〈糸など〉‘を'『紡ぐ』《+『名』+『out of』+『名』〈羊毛〉》,(糸などに)〈羊毛など〉‘を'紡ぐ《+『名』〈羊毛〉+『into』+『名』》 / 〈クモ・カイコなどが〉〈糸〉‘を'『吐く』;〈巣・繭〉‘を'かける / …‘を'くるくる回す / 〈物語など〉‘を'作る,話す / 『糸を紡ぐ』;〈クモ・カイコなどが〉糸を吐く / 〈こまなどが〉くるくる回る / 〈車などが〉疾走する / 〈頭などが〉くらくらする / 〈C〉〈U〉くるくる回すこと;回転 / 〈C〉《単数形で》(車などの)一走り / 〈C〉(飛行機の)きりもみ降下 / 〈C〉《単数形で》(価値などの)急落
2. 背骨の / せき髄麻酔
3. (体内にできる)新生物;腫瘍(しゅよう)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/21 17:22:05」(JST)

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Spinal tumors
Classification and external resources
Specialty	oncology
ICD-10	C72.0
ICD-9-CM	192.2
DiseasesDB	31483
MedlinePlus	001403
eMedicine	orthoped/49 med/2993, radio/169
MeSH	C04.557.465.220

Spinal tumors are neoplasms located in the spinal cord. Extradural tumors are more common than intradural neoplasms.

Depending on their location, the spinal cord tumors can be:

• Extradural - outside the dura mater lining (most common)
• Intradural - part of the dura
  • Intramedullary - inside the spinal cord
  • Extramedullary- inside the dura, but outside the spinal cord

Pathology

Extradural tumors are mostly metastases from primary cancers elsewhere (commonly breast, prostate and lung cancer). Intradural tumours can be classified as intramedullary (within the spinal parenchyma) or extramedullary (within the dura, but outside the spinal parenchyma). Extramedullary tumours are more common than intramedullary tumours. Common extramedullary tumours include meningiomas, schwannomas, extramedullary ependymomas, haemangioblastomas, while intramedullary tumours include astrocytomas and intramedullary ependymomas.

Symptoms

Pain is the most common symptom at presentation. The symptoms seen are due to spinal nerve compression and weakening of the vertebral structure. Incontinence and decreased sensitivity in the saddle area (buttocks) are generally considered warning signs of spinal cord compression by the tumor. Other symptoms of spinal cord compression include lower extremity weakness, sensory loss, and rapid onset paralysis. The diagnosis of primary spinal cord tumors is very difficult, mainly due to its symptoms, which tend to be wrongly attributed to more common and benign degenerative spinal diseases.

Spinal cord compression is commonly found in patients with metastatic malignancy. Back pain is a primary symptom of spinal cord compression in patients with known malignancy. It may prompt a bone scan to confirm or exclude spinal metastasis. Rapid identification and intervention of malignant spinal tumors, often causing spinal cord compression, is key to maintaining quality of life in patients.

Diagnosis

The diagnosis of primary spinal cord tumors is difficult, mainly due to their symptoms, which in early stages mimic more common and benign degenerative spinal diseases. MRI and bone scanning are used for diagnostic purposes. This assesses not only the location of the tumor(s) but also their relationship with the spinal cord and the risk of cord compression.

Treatment

• Steroids (e.g. corticosteroids) may be administered if there is evidence of spinal cord compression. These do not affect the tumoral mass itself, but tend to reduce the inflammatory reaction around it, and thus decrease the overall volume of the mass impinging on the spinal cord.
• Radiotherapy may be administered to patients with malignant tumors. Radiation is usually delivered to the involved segment in the spinal cord as well as to the uninvolved segment above and below the involved segment.
• Surgery is sometimes possible. The goals of surgical treatment for spinal tumors can include histologic diagnosis, tumor local control or oncological cure, pain relief, spinal cord decompression and restoration of neurological function, restoration of spine stability, and deformity rectification. Extramedullary tumours are more amenable to resection than intramedullary tumours.
• The combination of minimally invasive surgery and radiation or chemotherapy is a new technique for treating spinal tumors. This treatment can be tailored to the particular tumor of the spine, either metastatic or primary.

Some suggest that direct decompressive surgery combined with postoperative radiotherapy provide better outcomes than treatment with radiotherapy alone for patients with spinal cord compression due to metastatic cancer. It is also important to take into consideration the prognosis of the patients and their ambulation status at diagnosis, and treat accordingly.

References

UpToDate Contents

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• 1. 馬尾症候群などの腫瘍による硬膜外脊髄圧迫の臨床的特徴および診断 clinical features and diagnosis of neoplastic epidural spinal cord compression including cauda equina syndrome
• 2. 脊髄腫瘍 spinal cord tumors
• 3. 多発神経根症：脊柱管狭窄症、感染症、癌、および炎症性神経根症候群 polyradiculopathy spinal stenosis infectious carcinomatous and inflammatory nerve root syndromes
• 4. 脊髄性筋萎縮症 spinal muscular atrophy
• 5. 脊髄に影響を与える疾患 disorders affecting the spinal cord

English Journal

• Perineural spread of malignant mesothelioma with spinal intramedullary involvement.

• Tanwar M1, Simone CB 2nd2, Newman S1, Cengel K2, Yu GH3, Melhem ER1, Mohan S4.Author information 1Department of Radiology, Neuroradiology Division, Perelman School of Medicine at University of Pennsylvania, Philadelphia, 19104, USA.2Department of Radiation Oncology, Perelman School of Medicine at University of Pennsylvania, Philadelphia, 19104, USA.3Department of Pathology and Laboratory Medicine, Perelman School of Medicine at University of Pennsylvania, Philadelphia, 19104, USA.4Department of Radiology, Neuroradiology Division, Perelman School of Medicine at University of Pennsylvania, Philadelphia, 19104, USA. Electronic address: suyash.mohan@uphs.upenn.edu.KEYWORDS: Intramedullary tumor, Magnetic resonance imaging, Malignant pleural mesothelioma, Perineural spread, Spinal cord neoplasm
• Clinical neurology and neurosurgery.Clin Neurol Neurosurg.2014 May;120:116-9. doi: 10.1016/j.clineuro.2014.03.005. Epub 2014 Mar 13.
• PMID 24731589

• Skeletal-related events and mortality among older men with advanced prostate cancer.

• Onukwugha E1, Yong C2, Mullins CD2, Seal B3, McNally D2, Hussain A4.Author information 1Department of Pharmaceutical Health Services Research, University of Maryland School of Pharmacy, 220 Arch Street, Baltimore, MD 21201, USA. Electronic address: eonukwug@rx.umaryland.edu.2Department of Pharmaceutical Health Services Research, University of Maryland School of Pharmacy, 220 Arch Street, Baltimore, MD 21201, USA.3Bayer HealthCare Pharmaceuticals, Inc., USA.4University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201, USA; Veterans Affairs Medical Center, Baltimore, MD 21201, USA.AbstractOBJECTIVE: Skeletal-related events (SREs) are defined as a cluster of events including clinical diagnoses and treatment. Using claims data, the burden of SREs as a group has been reported among patients with cancer. We investigate the mortality impact of subcomponents of SREs, a topic that has received limited attention among older men.
• Journal of geriatric oncology.J Geriatr Oncol.2014 Apr 11. pii: S1879-4068(14)00061-7. doi: 10.1016/j.jgo.2014.03.002. [Epub ahead of print]
• OBJECTIVE: Skeletal-related events (SREs) are defined as a cluster of events including clinical diagnoses and treatment. Using claims data, the burden of SREs as a group has been reported among patients with cancer. We investigate the mortality impact of subcomponents of SREs, a topic that has recei
• PMID 24726866

• Intradural tumor recurrence after resection of extradural metastasis: a rare but potential complication of intraoperative durotomy.

• Kasliwal MK1, Tan LA, O'Toole JE.Author information 1Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois.AbstractSpinal metastases are the most common of spinal neoplasms and occur predominantly in an extradural location. Their appearance in an intradural location is uncommon and is associated with a poor prognosis. Cerebrospinal fluid dissemination accounts for a significant number of intradural spinal metastases mostly manifesting as leptomeningeal carcinomatoses or drop metastases from intracranial tumors. The occurrence of local tumor dissemination intradurally following surgery for an extradural spinal metastasis has not been reported previously. The authors describe 2 cases in which local intradural and intramedullary tumor recurrences occurred following resection of extradural metastases that were complicated by unintended durotomy. To heighten clinical awareness of this unusual form of local tumor recurrence, the authors discuss the possible etiology and clinical consequences of this entity.
• Journal of neurosurgery. Spine.J Neurosurg Spine.2014 Apr 11. [Epub ahead of print]
• Spinal metastases are the most common of spinal neoplasms and occur predominantly in an extradural location. Their appearance in an intradural location is uncommon and is associated with a poor prognosis. Cerebrospinal fluid dissemination accounts for a significant number of intradural spinal metast
• PMID 24725179

Japanese Journal

• 脊椎骨腫瘍の塞栓術

• 日本インターベンショナルラジオロジー学会雑誌 30(3), 235-241, 2015
• NAID 130005113950

• Melanotic Schwannoma of the Cervicall Spine Progressing With Pulmonary Metastasis : Case Report

• Neurologia medico-chirurgica = 神経外科 53(10), 712-716, 2013-10-15
• NAID 10031191643

• 膵管癌の危険因子としての膵嚢胞性疾患 : 多施設前向き観察研究による膵嚢胞の自然史解明の取り組み (特集 膵癌の早期発見をめざして)

• 消化器内科 57(1), 75-79, 2013-07
• NAID 40019775974

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★リンクテーブル★

リンク元	「脊椎腫瘍」「脊椎新生物」
関連記事	「spinal」「neoplasm」「spin」

「脊椎腫瘍」

　　[★]

英

spinal neoplasm

関

脊椎新生物

「脊椎新生物」

　　[★]

英

spinal neoplasm

関

脊椎腫瘍

「spinal」

　　[★]

• adj.

• 脊髄の、脊髄性の、脊柱の

関

dorsal spine、rachis、spinal column、spinal cord、spine、vertebral column

　 　

「neoplasm」

　　[★]

• n.

• 新生物、腫瘍

関

benign neoplasm、cancer、neoplasia、neoplastic、onco、oncologic、tumor、tumour

　

「spin」

　　[★]

• スピン