sodium channel antagonist

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  • Conditioned media from mesenchymal stromal cells restore sodium transport and preserve epithelial permeability in an in vitro model of acute alveolar injury.
  • Goolaerts A1, Pellan-Randrianarison N2, Larghero J3, Vanneaux V3, Uzunhan Y4, Gille T4, Dard N5, Planès C4, Matthay MA2, Clerici C6.
  • American journal of physiology. Lung cellular and molecular physiology.Am J Physiol Lung Cell Mol Physiol.2014 Jun 1;306(11):L975-85. doi: 10.1152/ajplung.00242.2013. Epub 2014 Mar 28.
  • Mesenchymal stromal cells (MSCs) or their media (MSC-M) were reported to reverse acute lung injury (ALI)-induced decrease of alveolar fluid clearance. To determine the mechanisms by which MSC-M exert their beneficial effects, an in vitro model of alveolar epithelial injury was created by exposing pr
  • PMID 24682451
  • Acute Hyperkalemia Associated with Inhalation of a Potent ENaC Antagonist: Phase 1 Trial of GS-9411.
  • O'Riordan TG1, Donn KH, Hodsman P, Ansede JH, Newcomb T, Lewis SA, Flitter WD, White VS, Johnson MR, Montgomery AB, Warnock DG, Boucher RC.
  • Journal of aerosol medicine and pulmonary drug delivery.J Aerosol Med Pulm Drug Deliv.2014 Jun;27(3):200-8. doi: 10.1089/jamp.2013.1037. Epub 2013 Aug 1.
  • Abstract Background: Inhaled epithelial sodium channel (ENaC) blockers are designed to increase airway surface liquid volume, thereby benefiting cystic fibrosis patients. This study evaluated the safety, tolerability, and pharmacokinetics of multiple doses of ENaC blocker GS-9411, in healthy partici
  • PMID 23905576


  • 羅布麻 (紅麻:Apocynum venetum L.) 葉エキスの降圧作用に関する研究(3)
  • 田川 智恵,香川 珠実,中澤 慶久 [他],鬼塚 重則,西部 三省,川崎 博己
  • 藥學雜誌 124(11), 851-856, 2004-11-01
  • 羅布麻葉(Luobuma)はキョウチクトウ科(Apocynaceae)の多年生草本であるApocynum venetum L.(紅麻)の葉部を乾燥した生薬である.羅布麻葉は中華人民共和国薬典に収載され,心臓病,高血圧,不眠症,神経衰弱,腎炎,浮腫に用いるとされている.また羅布麻は内モンゴル遊牧民の伝統的なお茶としても飲まれていたとの報告があり,高血圧に関しては,羅布麻葉を煎じてお茶の代わりに毎日服 …
  • NAID 110003666142
  • Effects of Novel Synthesized Pyridothiazines on Various Guinea Pig Heart Muscle Preparations(Pharmacology)
  • Schade Bettina,Erker Thomas,Weber Manuela [他],STUDENIK Christian
  • Biological & pharmaceutical bulletin 27(9), 1364-1370, 2004-09-01
  • … Calcium channel blockers have become important tools in the treatment of cardiovascular disorders and other diseases. … Hybridization of well established calcium antagonist subclasses was an attempt to optimize their pharmacological profile. … In contrast to the mother compound KT-362 they do not seem to affect the fast sodium inward current. …
  • NAID 110003608977


Sodium channel blocker. From Wikipedia, the free encyclopedia. Jump to: navigation, search. Sodium channel blockers are agents that impair conduction of sodium ions (Na+) through sodium channels. Contents. 1 Extracellular; 2 Intracellular ...



関連記事channel」「sodium」「antagonist」「channels」「sodium channel



  • n.
  • 川床、川底。水路、河道
  • 海峡
  • 水管、導管
  • 経路、ルート。道筋、方向
ion channelionic channel

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「direct the flow of; "channel information towards a broad audience"」
canalize, canalise

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「a television station and its programs; "a satellite TV channel"; "surfing through the channels"; "they offer more than one hundred channels"」
television channel, TV channel

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「a passage for water (or other fluids) to flow through; "the fields were crossed with irrigation channels"; "gutters carried off the rainwater into a series of channels under the street"」

WordNet   license wordnet

「(often plural) a means of communication or access; "it must go through official channels"; "lines of communication were set up between the two firms"」
communication channel, line

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「a path over which electrical signals can pass; "a channel is typically what you rent from a telephone company"」
transmission channel

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「a deep and relatively narrow body of water (as in a river or a harbor or a strait linking two larger bodies) that allows the best passage for vessels; "the ship went aground in the channel"」

PrepTutorEJDIC   license prepejdic

「〈C〉『水路』(川・湾・運河の船の通行ができる深い部分) / 〈U〉河床・川底 / 〈C〉『海峡』 / 〈C〉みぞ(groove),(道路の)水渠(すいきょ) / 《複数形で》(運搬・伝達の)正式の経路(手続き);(一般に)経路 / 〈C〉(テレビ・ラジオの)チャンネル / …‘に'水路を開く / …‘に'みぞを堀る / …'を'伝える,流す」


  [★] ナトリウム

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「a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt)」
Na, atomic number 11

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  [★] 拮抗薬

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「a drug that neutralizes or counteracts the effects of another drug」

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「a muscle that relaxes while another contracts; "when bending the elbow the triceps are the antagonist"」

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  [★] チャネル

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「official routes of communication; "you have to go through channels"」

sodium channel」



Na channel、Na+ channel