印環細胞

WordNet

place signs, as along a road; "sign an intersection"; "This road has been signed"
(medicine) any objective evidence of the presence of a disorder or disease; "there were no signs of asphyxiation"
a perceptible indication of something not immediately apparent (as a visible clue that something has happened); "he showed signs of strain"; "they welcomed the signs of spring" (同)mark
a character indicating a relation between quantities; "dont forget the minus sign"
a fundamental linguistic unit linking a signifier to that which is signified; "The bond between the signifier and the signified is arbitrary"--de Saussure
a gesture that is part of a sign language
a public display of a message; "he posted signs in all the shop windows"
engage by written agreement; "They signed two new pitchers for the next season" (同)contract, sign on, sign_up
approve and express assent, responsibility, or obligation; "All parties ratified the peace treaty"; "Have you signed your contract yet?" (同)ratify
communicate silently and non-verbally by signals or signs; "He signed his disapproval with a dismissive hand gesture"; "The diner signaled the waiters to bring the menu" (同)signal, signalize, signalise
mark with ones signature; write ones name (on); "She signed the letter and sent it off"; "Please sign here" (同)subscribe
be engaged by a written agreement; "He signed to play the casino on Dec. 18"; "The soprano signed to sing the new opera"
communicate in sign language; "I dont know how to sign, so I could not communicate with my deaf cousin"
sound loudly and sonorously; "the bells rang" (同)peal
a toroidal shape; "a ring of ships in the harbor"; "a halo of smoke" (同)halo, annulus, doughnut, anchor ring
jewelry consisting of a circlet of precious metal (often set with jewels) worn on the finger; "she had rings on every finger"; "he noted that she wore a wedding band" (同)band
a characteristic sound; "it has the ring of sincerity"
a platform usually marked off by ropes in which contestants box or wrestle
the sound of a bell ringing; "the distinctive ring of the church bell"; "the ringing of the telephone"; "the tintinnabulation that so voluminously swells from the ringing and the dinging of the bells"--E. A. Poe (同)ringing, tintinnabulation
attach a ring to the foot of, in order to identify; "ring birds"; "band the geese to observe their migratory patterns" (同)band
make (bells) ring, often for the purposes of musical edification; "Ring the bells"; "My uncle rings every Sunday at the local church" (同)knell
small room in which a monk or nun lives (同)cubicle
a device that delivers an electric current as the result of a chemical reaction (同)electric cell
a room where a prisoner is kept (同)jail cell, prison cell
(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
any small compartment; "the cells of a honeycomb"
a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
wearing a wedding ring; lawfully married; "a ringed wife"- Tennyson
having colored rings around the body
gymnastic apparatus consisting of a pair of heavy metal circles (usually covered with leather) suspended by ropes; used for gymnastic exercises; "the rings require a strong upper body"

PrepTutorEJDIC

(ある事実・状態・感情などの)『表れ』,印,気配,徴侯(indication);(…の)こん跡,計跡《+『of』+『名』》・『身ぶり』,手まね,合図 / 『標識』,看板 / (数学・音楽などの)記号 / (…の)『象徴』,シンボル(symbol)《+『of』+『名』》・《文》(…の)『前兆』,きざし《+『of』+『名』》・宮(きゅう)(黄道12区分の一つ) ・〈手紙・書類・作品など〉‘に'『署名する』・(…に)〈名前など〉‘を'書く《+『名』+『on』(『to』)+『名』》 / …‘を'雇う契約に署名する・…‘を'合図する,知らせる;…に合図する・署名する・契約書に署名して雇われる
『指輪』 / 『輪』,環;輪形,円形 / (円形の)サーカス演技場,公演場,競技場;(ボクシング・レスリングの)リング / 《複数形で》(体操の)つり輪 / (不法な目的で結託した)(…の)徒党,一味《+『of』+『名』》 / (原子の)環 / …を円形に取り囲む,円で囲む《+『about』(『around』,《英》『round』)+『名,』+『名』+『about』(『around』,《英》『round』)+『名』》 / 〈動物〉‘に'鼻輪(首輪,足輪)をはめる / (遊びで)…‘に'輪を投げる / 環状に動く,輪を描く
〈鐘・ベルなどが〉『鳴る』 / 《『ring』+『形』〈補〉》(…のように)聞こえる / (…を)ベルを鳴らして求める《+『for』+『名』》 / 〈音声・楽器などが〉鳴り響く;〈場所が〉(音などで)満ちる《+『with』+『名』》 / 耳鳴りがする / 〈鐘・ベルなど〉‘を'『鳴らす』 / 〈人〉‘を'(鐘などを)『鳴らして呼ぶ』;…‘を'鐘を鳴らして知らせる / 《英》…‘に'電話をかける《+『up』+『名』,+『名』+『up』》 / 《単数形で》(鐘・ベルなどの)『鳴る音,響き』《+『of』+『名』》 / 鐘(ベルなど)を鳴らすこと;ベル(など)が鳴ること / 《単数形で》(…の)固有の響き,調子,感じ《+『of』+『名』》 / 《話》電話をかけること
(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
輪にある;環状の / 指輪をはめた

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/02 00:07:36」(JST)

wiki en

High magnification micrograph showing signet ring cells, with clear cytoplasm, in metastatic breast carcinoma. H&E stain.

Signet ring cells (magenta) stained with PAS in a gastric signet ring cell carcinoma.

Gastric signet ring cell carcinoma. H&E stain.

In histology, a signet ring cell is a malignant cell type seen predominantly in carcinomas.

Signet ring cells are most frequently associated with stomach cancer,^[1] but can arise from any number of tissues including the prostate,^[2] bladder, gallbladder,^[3] breast, colon,^[4] ovarian stroma and testis.^[5]

Appearance

The name of the cell comes from its appearance; signet ring cells resemble signet rings. They contain a large amount of mucin, which pushes the nucleus to the cell periphery. The pool of mucin in a signet ring cell mimics the appearance of a finger hole and the nucleus mimics the appearance of the face of the ring in profile.

Diagnostic significance

A significant number of signet ring cells, generally, are associated with a worse prognosis.^[6]^[7]

Classification

SRC carcinomas can be classified using immunohistochemistry.^[8]

References

^ Cancer Research UK. Signet Ring Cancer. cancerhelp.org.uk. URL: http://www.cancerhelp.org.uk/help/default.asp?page=7581. Accessed on: November 2, 2007.
^ Leong FJ, Leong AS, Swift J (1996). "Signet-ring carcinoma of the prostate". Pathol. Res. Pract. 192 (12): 1232–8; discussion 1239–41. PMID 9182294.
^ Jain V, Gupta K, Kudva R, Rodrigues GS (2006). "A case of ovarian metastasis of gallbladder carcinoma simulating primary ovarian neoplasm: diagnostic pitfalls and review of literature". Int. J. Gynecol. Cancer 16 Suppl 1: 319–21. doi:10.1111/j.1525-1438.2006.00335.x. PMID 16515613.
^ Makino T, Tsujinaka T, Mishima H, et al. (2006). "Primary signet-ring cell carcinoma of the colon and rectum: report of eight cases and review of 154 Japanese cases". Hepatogastroenterology 53 (72): 845–9. PMID 17153438.
^ Michal M, Hes O, Kazakov DV (2005). "Primary signet-ring stromal tumor of the testis". Virchows Arch. 447 (1): 107–10. doi:10.1007/s00428-005-1218-2. PMID 15909171.
^ Lee WS, Chun HK, Lee WY, et al. (2007). "Treatment outcomes in patients with signet ring cell carcinoma of the colorectum". Am. J. Surg. 194 (3): 294–8. doi:10.1016/j.amjsurg.2006.12.041. PMID 17693269.
^ Cabebe EC, Mehta VK, Fisher G. Gastric Cancer. eMedicine.com. URL: http://www.emedicine.com/med/topic845.htm. Accessed on: November 8, 2007.
^ Tian MM, Zhao AL, Li ZW, Li JY (2007). "Phenotypic classification of gastric signet ring cell carcinoma and its relationship with clinicopathologic parameters and prognosis". World J. Gastroenterol. 13 (23): 3189–98. PMID 17589897.

External links

Signet ring cells - med.Utah.edu.
Pictures of a signet ring - engravingart.com.
Signet ring cell definition - cancer.gov.
Signet ring cell cancer information - sites.google.com/site/signetringcancer.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 胃癌の病理および分子学的病因 pathology and molecular pathogenesis of gastric cancer
2. 肺悪性腫瘍の病理 pathology of lung malignancies
3. 原発不明の腺癌 adenocarcinoma of unknown primary site
4. 大腸癌の病理および予後決定因子 pathology and prognostic determinants of colorectal cancer
5. The treatment approach to non-clear cell renal carcinoma

English Journal

Is preoperative chemotherapy followed by surgery the appropriate treatment for signet ring cell containing adenocarcinomas of the esophagogastric junction and stomach?

Heger U1, Blank S, Wiecha C, Langer R, Weichert W, Lordick F, Bruckner T, Dobritz M, Burian M, Springfeld C, Grenacher L, Siewert JR, Büchler M, Ott K.Author information 1Department of Surgery, Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany, ulrike.heger@med.uni-heidelberg.de.AbstractBACKGROUND: Recent data suggest primary resection as the preferable approach in patients with signet ring cell gastric cancer (SRC). The aim of our retrospective exploratory study was to evaluate the influence of SRC on prognosis and response in esophagogastric adenocarcinoma treated with neoadjuvant chemotherapy.
Annals of surgical oncology.Ann Surg Oncol.2014 May;21(5):1739-48. doi: 10.1245/s10434-013-3462-z. Epub 2014 Jan 14.
BACKGROUND: Recent data suggest primary resection as the preferable approach in patients with signet ring cell gastric cancer (SRC). The aim of our retrospective exploratory study was to evaluate the influence of SRC on prognosis and response in esophagogastric adenocarcinoma treated with neoadjuvan
PMID 24419755

Stage-stratified prognosis of signet ring cell histology in patients undergoing curative resection for gastric adenocarcinoma.

Bamboat ZM1, Tang LH, Vinuela E, Kuk D, Gonen M, Shah MA, Brennan MF, Coit DG, Strong VE.Author information 1Gastric and Mixed Tumor Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.AbstractBACKGROUND: The prognosis of signet ring cell (SRC) gastric adenocarcinoma is regarded as poor, although studies addressing outcomes in relation to non-SRC tumors are conflicting. Our objective was to compare the survival of SRC tumors with stage-matched intestinal-type tumors in a cohort of Western patients.
Annals of surgical oncology.Ann Surg Oncol.2014 May;21(5):1678-85. doi: 10.1245/s10434-013-3466-8. Epub 2014 Jan 7.
BACKGROUND: The prognosis of signet ring cell (SRC) gastric adenocarcinoma is regarded as poor, although studies addressing outcomes in relation to non-SRC tumors are conflicting. Our objective was to compare the survival of SRC tumors with stage-matched intestinal-type tumors in a cohort of Western
PMID 24394986

Impact of aggressive histology and location of primary tumor on the efficacy of surgical therapy for peritoneal carcinomatosis of colorectal origin.

Winer J1, Zenati M, Ramalingam L, Jones H, Zureikat A, Holtzman M, Lee K, Ahrendt S, Pingpank J, Zeh HJ, Bartlett DL, Choudry HA.Author information 1Division of Surgical Oncology, University of Pittsburgh, Pittsburgh, PA, USA.AbstractBACKGROUND: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemoperfusion (HIPEC) for peritoneal carcinomatosis (PC) of colorectal origin increases survival (OS) compared to systemic chemotherapy alone. Signet ring histology demonstrates aggressive behavior with poor survival. We sought to determine whether CRS/HIPEC increases survival in this subset of patients.
Annals of surgical oncology.Ann Surg Oncol.2014 May;21(5):1456-62. doi: 10.1245/s10434-013-3328-4. Epub 2013 Nov 8.
BACKGROUND: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemoperfusion (HIPEC) for peritoneal carcinomatosis (PC) of colorectal origin increases survival (OS) compared to systemic chemotherapy alone. Signet ring histology demonstrates aggressive behavior with poor survival. We sough
PMID 24201745