selective vulnerability

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  • L-type Ca(2+) currents at CA1 synapses, but not CA3 or dentate granule neuron synapses, are increased in 3xTgAD mice in an age-dependent manner.
  • Wang Y, Mattson MP.SourceLaboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA. Electronic address:
  • Neurobiology of aging.Neurobiol Aging.2014 Jan;35(1):88-95. doi: 10.1016/j.neurobiolaging.2013.07.007. Epub 2013 Aug 7.
  • Abnormal neuronal excitability and impaired synaptic plasticity might occur before the degeneration and death of neurons in Alzheimer's disease (AD). To elucidate potential biophysical alterations underlying aberrant neuronal network activity in AD, we performed whole-cell patch clamp analyses of L-
  • PMID 23932880
  • Cognitive biases in patients with chronic obstructive pulmonary disease and depression - a pilot study.
  • Fritzsche A, Watz H, Magnussen H, Tuinmann G, Löwe B, von Leupoldt A.SourceDepartment of Psychology, University of Hamburg, Germany.
  • British journal of health psychology.Br J Health Psychol.2013 Nov;18(4):827-43. doi: 10.1111/bjhp.12025. Epub 2013 Jan 25.
  • OBJECTIVES: Comorbid depression is highly prevalent in patients with chronic obstructive pulmonary disease (COPD) and associated with a worse course of disease; however, the exact mechanisms linking both remain unclear. In currently depressed individuals without lung disease, depression-specific bia
  • PMID 23351008


  • チアミン(ビタミンB1)欠乏による神経組織障害
  • 濱田 俊
  • 比較生理生化学 31(1), 13-19, 2014
  • チアミン(ビタミンB1)はエネルギー代謝に不可欠の補酵素であり,その欠乏は神経系に特有の障害を引き起こす。ヒトでは2種類のチアミン欠乏症,脚気とWernicke-Korsakoff症候群(WKS)がみられるが,脚気では主に末梢神経系が障害される一方,WKSでは中枢神経系が障害される。なぜ単一のビタミンが異なる2種類の病態を引き起こすのかよくわかっていない。WKSの神経組織障害は,多くの神経変性疾患 …
  • NAID 130003394319
  • Differential Effect of Phosphodiesterase-3 Inhibitors on Sympathetic Hyperinnervation in Healed Rat Infarcts
  • Lee Tsung-Ming,Lin Shinn-Zong,Chang Nen-Chung
  • Circulation Journal 78(2), 366-376, 2014
  • … Furthermore, the inhibitory effect of cilostazol on nerve growth factor was reversed by 8-cyclopentyl-1,3-dipropylxanthine, a selective A1 receptor antagonist, and enhanced by tempol administration. … In spite of similar arrhythmic vulnerability during programmed stimulation in both the vehicle-and cilostazol-treated groups, cilostazol did not have proarrhythmic effects compared with milrinone. …
  • NAID 130003382227


The Selective Vulnerability Research Laboratory is led by Dr. William Seeley, a neurologist and clinician-scientist at the UCSF Memory and Aging Center (MAC) who specializes in neurodegenerative disease. We study human brain ...
Gosztonyi G, Koprowski H. The concept of neurotropism and selective vulnerability (“pathoclisis”) in virus infections of the nervous systema historical overview. Curr Top Microbiol Immunol 2001; 253: 1–13 Gosztonyi G, Koprowski ...


Von Economo Neurons and Fork CellsHome People Selective Vulnerability of the CerebellumResearch - Selective Vulnerability Selective Vulnerability Research Lab Research - Selective Vulnerability




  • adj.
  • 選択的な、選択性の、選択の

WordNet   license wordnet

「tending to select; characterized by careful choice; "an exceptionally quick and selective reader"- John Mason Brown」

PrepTutorEJDIC   license prepejdic

「選択の,染択する / 注意して選ばれた / 淘汰(とうた)の / (無線が)選択度の高い」

WordNet   license wordnet

「characterized by very careful or fastidious selection; "the school was very selective in its admissions"」




WordNet   license wordnet

「the state of being vulnerable or exposed; "his vulnerability to litigation"; "his exposure to ridicule"」

PrepTutorEJDIC   license prepejdic


WordNet   license wordnet

「susceptibility to injury or attack」