WordNet

an unstable situation of extreme danger or difficulty; "they went bankrupt during the economic crisis"
a crucial stage or turning point in the course of something; "after the crisis the patient either dies or gets better"
an autoimmune disease that affects the blood vessels and connective tissue; fibrous connective tissue is deposited in the skin (同)dermatosclerosis
genus of poisonous fungi having hard-skinned fruiting bodies: false truffles (同)genus Scleroderma

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1. 強皮症腎クリーゼを含む全身性硬化症（強皮症）における腎疾患 renal disease in systemic sclerosis scleroderma including scleroderma renal crisis
2. 成人における全身性硬化症（強皮症）の臨床症状の概要 overview of the clinical manifestations of systemic sclerosis scleroderma in adults
3. 機械的損傷による外因性非免疫性溶血性貧血：断片化溶血および脾機能亢進 extrinsic nonimmune hemolytic anemia due to mechanical damage fragmentation hemolysis and hypersplenism
4. 成人における全身性硬化症（強皮症）の治療および予後の概要 overview of the treatment and prognosis of systemic sclerosis scleroderma in adults
5. 成人における全身性硬化症（強皮症）の診断および鑑別診断 diagnosis and differential diagnosis of systemic sclerosis scleroderma in adults

Clinical and Immunologic Predictors of Scleroderma Renal Crisis in Japanese Systemic Sclerosis Patients With Anti-RNA Polymerase III Autoantibodies.

Hamaguchi Y1, Kodera M, Matsushita T, Hasegawa M, Inaba Y, Usuda T, Kuwana M, Takehara K, Fujimoto M.
Arthritis & rheumatology (Hoboken, N.J.).Arthritis Rheumatol.2015 Apr;67(4):1045-52. doi: 10.1002/art.38994.
OBJECTIVE: To identify predictive factors for scleroderma renal crisis (SRC) in patients with anti-RNA polymerase III (anti-RNAP III) antibodies.METHODS: A total of 583 adult Japanese patients with systemic sclerosis (SSc) were screened for anti-RNAP III using a commercially available enzyme-linked
PMID 25512203

A possible contribution of lipocalin-2 to the development of dermal fibrosis, pulmonary vascular involvement, and renal dysfunction in systemic sclerosis.

Takahashi T1, Asano Y, Noda S, Aozasa N, Akamata K, Taniguchi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Tada Y, Sugaya M, Kadono T, Sato S.
The British journal of dermatology.Br J Dermatol.2015 Mar 17. doi: 10.1111/bjd.13779. [Epub ahead of print]
BACKGROUND: Lipocalin-2 is an adipocytokine implicated in apoptosis, innate immunity, angiogenesis, and the development of chronic kidney disease.OBJECTIVES: To investigate the role of lipocalin-2 in systemic sclerosis (SSc).METHODS: Serum lipocalin-2 levels were determined by enzyme-linked immunoso
PMID 25781362

Scleroderma renal crisis during intravenous cyclophosphamide pulse therapy for complicated interstitial lung disease was successfully treated with angiotensin converting enzyme inhibitor and plasma exchange