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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/28 11:42:13」(JST)

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Rokitamycin is a macrolide antibiotic. Synthesized from strains of Streptomyces kitasatoensis.

External links

Recent Publications on Rokitamycin

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English Journal

Amebic meningoencephalitides and keratitis: challenges in diagnosis and treatment.

Visvesvara GS.SourceCenters for Disease Control and Prevention, Atlanta, Georgia 30333, USA. gsv1@cdc.gov
Current opinion in infectious diseases.Curr Opin Infect Dis.2010 Dec;23(6):590-4.
PURPOSE OF REVIEW: Acanthamoeba spp., Balamuthia mandrillaris, and Naegleria fowleri, although free-living amebae, also cause devastating diseases in humans leading to death. Acanthamoeba spp. and B. mandrillaris cause granulomatous amebic encephalitis, cutaneous and nasopharyngeal as well as dissem
PMID 20802332

Influence of chitosan glutamate on the in vivo intranasal absorption of rokitamycin from microspheres.

Gavini E, Rassu G, Ferraro L, Generosi A, Rau JV, Brunetti A, Giunchedi P, Dalpiaz A.SourceDepartment of Drug Sciences, University of Sassari, Sassari 07100, Italy.
Journal of pharmaceutical sciences.J Pharm Sci.2010 Oct 29. [Epub ahead of print]
Intranasal delivery is an alternative method to target therapeutics to the central nervous system. In the present study, chitosan glutamate (CG)-based mucoadhesive microspheres containing rokitamycin (RK) were prepared by spray-drying and in vitro characterization. Moreover, the influence of CG on R
PMID 21038406

Japanese Journal

Protective Effects of Clarithromycin, a Lipophilic 14-membered Macrolide, on Hemolysis Induced by Lysophosphatidylcholine in Human Erythrocytes

医療薬学 38(10), 617-627, 2012
NAID 130004502711

試験管内でセレクションされたマクロライド耐性 Mycoplasma pneumoniae について : アジスロマイシンとロキタマイシンにおける耐性菌セレクションの比較

日本マイコプラズマ学会雑誌 = Japanese Journal of Mycoplasmology 37, 55-58, 2011-03-31
NAID 10029813475

Rokitamycin Induces a Mitochondrial Defect and Caspase-Dependent Apoptosis in Human T-Cell Leukemia Jurkat Cells

Journal of pharmacological sciences 110(1), 69-77, 2009-05-20
NAID 10025736657

Related Pictures

★リンクテーブル★

リンク元	「マクロライド系抗菌薬」「ロキタマイシン」

「マクロライド系抗菌薬」

Rokitamycin
Systematic (IUPAC) name
	(2S,3S,4R,6S)-6-{[(2R,3S,4R,5R,6S)-6-{[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-4,10-dihydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy}-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy}-2,4-dimethyl-4-propoxyoxan-3-yl butanoate
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Registry Number	74014-51-0
ATC code	J01FA12
PubChem	CID 5282211
ChemSpider	4445397
UNII	ZPT03UEM0E
ChEMBL	CHEMBL1908350
Chemical data
Formula	C42H71NO14
Molecular mass	827.999 g/mol
	SMILES O=CC[C@H]3C[C@@H](C)[C@@H](O)/C=C/C=C/C[C@H](OC(=O)C[C@@H](O)[C@H](OC)[C@H]3O[C@@H]2O[C@@H]([C@@H](O[C@@H]1O[C@H]([C@H](OC(=O)CCC)[C@](OC(=O)CC)(C1)C)C)[C@H](N(C)C)[C@H]2O)C)C;
	InChI InChI=1S/C42H69NO15/c1-11-16-32(48)55-40-27(6)53-34(23-42(40,7)58-31(47)12-2)56-37-26(5)54-41(36(50)35(37)43(8)9)57-38-28(19-20-44)21-24(3)29(45)18-15-13-14-17-25(4)52-33(49)22-30(46)39(38)51-10/h13-15,18,20,24-30,34-41,45-46,50H,11-12,16-17,19,21-23H2,1-10H3/b14-13+,18-15+/t24-,25-,26-,27+,28+,29+,30-,34+,35-,36-,37-,38+,39+,40+,41+,42-/m1/s1 ; Key:VYWWNRMSAPEJLS-MDWYKHENSA-N ;
Physical data
Melting point	116 °C (241 °F)
Solubility in water	Insoluble in water; Very soluble in chloroform and methanol; Almost completely (>99.5 %) in ethanol and acetonitrile. mg/mL (20 °C)
(what is this?) (verify)

　　[★]

英: macrolide antibiotic macrolide antibiotics, macrolides, MLs
同: マクロライド系抗生物質　←厳密には違うが、多くの人が間違って使っている
関: 抗菌薬

特徴

抗菌スペクトルが広い
静菌的に作用
大きな環状構造を有する。14員環-16員環
タンパク質合成阻害薬
抗生物質としての作用の他に、抗炎症作用を有するらしい

炎症の抑制 ex.びまん性汎細気管支炎

構造

http://www.sigmaaldrich.com/life-science/life-science-catalog/product-catalog.html?TablePage=14572877
Macrolide antibiotics contain a many-membered lactone ring (14-membered rings for erythromycin and clarithromycin and a 15-membered ring for azithromycin) to which are attached one or more deoxy sugars. Clarithromycin differs from erythromycin only by methylation of the hydroxyl group at the 6 position, and azithromycin differs by the addition of a methyl-substituted nitrogen atom into the lactone ring. These structural modifications improve acid stability and tissue penetration and broaden the spectrum of activity.(GOO. chapter 46)

作用機序

50Sリボソームに結合してタンパク質合成を阻害

inhibit bacterial protein synthesis by reacting with the 50s ribosomal subunit and preventing the release of the uncharged tRNA.

薬理作用

動態

経口で吸収される

抗菌スペクトル

ペニシリンより広い抗菌スペクトル
グラム陽性球菌、グラム陰性球菌、グラム陰性桿菌、スピロヘータ、一部のリケッチア、ウイルス

適応

マイコプラズマ肺炎、クラミジア感染症、カンピロバクター腸炎、レジオネラ症
びまん性汎細気管支炎：14員環マクロライドのみ
URIs, pneumonias, STD

グラム陽性球菌(ペニシリンアレルギー), Mycoplasma, Legionella, Chlamydia, Neisseria

注意

禁忌

副作用

肝障害
消化器障害
QT延長、心室性不整脈

悪心、嘔吐、消化器の蠕動を促進

薬物相互作用

テオフィリン

喘息の治療薬。CYP3A4で代謝される。中毒域と治療域がちかいので注意する

マクロライド系抗菌薬

14員環

15員環

アジスロマイシン azithromycin

16員環

14員環 (ケトライド系抗菌薬)

テリスロマイシン telithromycin　→　厳密にはケトライド系

有効性 (SMB.147)

○：殺菌的、△静菌的

「ロキタマイシン」

　　[★]

英: rokitamycin, RKM
商: リカマイシン
関: 抗菌薬

匿名

検索

案内

案内

rokitamycin