retinoid

出典: meddic


specific agents

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/06/28 12:14:00」(JST)

wiki en

[Wiki en表示]

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

英文文献

  • Novel treatment of acute promyelocytic leukemia: As₂O₃, retinoic acid and retinoid pharmacology.
  • Zhu G, Mische SE, Seigneres B1.Author information 1Institute of Oncology of George Zhu, 422407, Beijing, China. sansan4240732@163.com.AbstractAcute promyelocytic leukemia(APL), a specific characteristic of t(15;17) chromosome translocation, represents 5% to 15% of cases of acute nonlymphocytic leukemia. An alternative approach is to consider retinoic acid(all-trans RA, ATRA or 13-cis RA or 9-cis RA) plus chemotherapy or RA plus As₂O₃ regimens as now novel therapy. Molecular gene analyses are conclusive in vivo evidence that oncogenic PML/RARa plays a crucial role in APL leukemogenesis. As a novel approach to APL treatment, one possible the action of RA, A consense sequence (5'-TCAGGTCATGACCTGA-3') has been postulated for the thyroid hormone (TRE) and retinoic acid responsive element (RARE) containing half palindromes, which located in the promoter region of target genes. High dose (100-fold) of RA-RARE-PML/RARa complex in intracellular localization appears to relieve repressor from DNA binding, including corepressors N-CoR, SMRT and HDACs, release PML/RARa- mediated transcriptional repression, and release histone deacetylase activity from PMLRARa. The resulting PML/RARa oncoprotein proteolytic degradation through the autophagy-lysosome pathway and the ubiquitin SUMO-proteasome system (UPS), as well as caspase 3 (cleavage site Asp522 within a-helics region of PML component of the fusion protein) or neutrophil elastase, or lysosomal protease enzyme induction. PML protein relocalizes into the wild-type nuclear body (PML-NB) configuration or/and wild-type RARa upregulated. An effect to relieve the blockade (inhibition) of PML/RARA-mediated RA dependent promyelocytic differentiation, and retinoic acid in APL therapy (see Figure in the full text, George Zhu, 1991). Here, like v-erbA, PML/RARa is a (strong) transcriptional repressor of the RA receptor (RAR) complex, and PML/RARa fusion receptor gene act as conditional oncogenic receptor (translocated chimeric retinoic acid a signaling) or oncogenic PML/RARa may participate in leukemogenesis of APL through blocking RA-mediated promyelocytic differentiation. This is first described in eukaryotes.
  • Current pharmaceutical biotechnology.Curr Pharm Biotechnol.2014 Oct;14(9):849-58.
  • Acute promyelocytic leukemia(APL), a specific characteristic of t(15;17) chromosome translocation, represents 5% to 15% of cases of acute nonlymphocytic leukemia. An alternative approach is to consider retinoic acid(all-trans RA, ATRA or 13-cis RA or 9-cis RA) plus chemotherapy or RA plus As₂O₃
  • PMID 24433507
  • An N-terminal splice variant of human Stat5a that interacts with different transcription factors is the dominant form expressed in invasive ductal carcinoma.
  • Tan D1, Chen KE2, Deng C3, Tang P4, Huang J4, Mansour T2, Luben RA3, Walker AM5.Author information 1Division of Biomedical Sciences, University of California, Riverside, Riverside, CA 92521-0121, United States; College of Medicine/Institute of Medical Sciences, Jishou University, Jishou 416000, Hunan, PR China.2Division of Biomedical Sciences, University of California, Riverside, Riverside, CA 92521-0121, United States.3Division of Biomedical Sciences, University of California, Riverside, Riverside, CA 92521-0121, United States; Department of Biochemistry, University of California, Riverside, Riverside, CA 92521-0121, United States.4People's Hospital of Xiangxi Autonomous Region, Jishou University, Jishou 416000, Hunan, PR China.5Division of Biomedical Sciences, University of California, Riverside, Riverside, CA 92521-0121, United States. Electronic address: ameae.walker@ucr.edu.AbstractWe have identified a new variant of human Stat5a, found at higher ratios to full-length Stat5a in invasive ductal carcinoma versus contiguous normal tissue. The variant, missing exon 5, inhibits p21 and Bax production and increases cell number. After prolactin stimulation, only full-length Stat5a interacts with the vitamin D and retinoid X receptors, whereas only Δ5 Stat5a interacts with activating protein 1-2 and specificity protein 1. Prolactin also oppositely regulates interaction of the two Stat5a forms with β-catenin. We propose that a change in splicing leading to upregulation of this new isoform is a pathogenic aspect of invasive ductal carcinoma.
  • Cancer letters.Cancer Lett.2014 Apr 28;346(1):148-57. doi: 10.1016/j.canlet.2013.12.030. Epub 2013 Dec 30.
  • We have identified a new variant of human Stat5a, found at higher ratios to full-length Stat5a in invasive ductal carcinoma versus contiguous normal tissue. The variant, missing exon 5, inhibits p21 and Bax production and increases cell number. After prolactin stimulation, only full-length Stat5a in
  • PMID 24384092
  • Ex-vivo tolerogenic F4/80(+) antigen-presenting cells (APC) induce efferent CD8(+) regulatory T cell-dependent suppression of experimental autoimmune uveitis.
  • Hsu SM1, Mathew R, Taylor AW, Stein-Streilein J.Author information 1Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; Department of Ophthalmology, National Cheng-Kung University Hospital, Tainan City, Taiwan.AbstractIt is known that inoculation of antigen into the anterior chamber (a.c.) of a mouse eye induces a.c.-associated immune deviation (ACAID), which is mediated in part by antigen-specific local and peripheral tolerance to the inciting antigen. ACAID can also be induced in vivo by intravenous (i.v.) inoculation of ex-vivo-generated tolerogenic antigen-presenting cells (TolAPC). The purpose of this study was to test if in-vitro-generated retinal antigen-pulsed TolAPC suppressed established experimental autoimmune uveitis (EAU). Retinal antigen-pulsed TolAPC were injected i.v. into mice 7 days post-induction of EAU. We observed that retinal antigen-pulsed TolAPC suppressed the incidence and severity of the clinical expression of EAU and reduced the expression of associated inflammatory cytokines. Moreover, extract of whole retina efficiently replaced interphotoreceptor retinoid-binding protein (IRBP) in the preparation of TolAPC used to induce tolerance in EAU mice. Finally, the suppression of EAU could be transferred to a new set of EAU mice with CD8(+) but not with CD4(+) regulatory T cells (Treg ). Retinal antigen-pulsed TolAPC suppressed ongoing EAU by inducing CD8(+) Treg cells that, in turn, suppressed the effector activity of the IRBP-specific T cells and altered the clinical symptoms of autoimmune inflammation in the eye. The ability to use retinal extract for the antigen raises the possibility that retinal extract could be used to produce autologous TolAPC and then used as therapy in human uveitis.
  • Clinical and experimental immunology.Clin Exp Immunol.2014 Apr;176(1):37-48. doi: 10.1111/cei.12243.
  • It is known that inoculation of antigen into the anterior chamber (a.c.) of a mouse eye induces a.c.-associated immune deviation (ACAID), which is mediated in part by antigen-specific local and peripheral tolerance to the inciting antigen. ACAID can also be induced in vivo by intravenous (i.v.) inoc
  • PMID 24266626

和文文献

  • ビタミンA核内受容体機能制御剤の開発と医薬応用に関する研究
  • 白血病治療薬剤ATRAの新規標的分子,プロリン異性化酵素Pin1 (特集 代謝と血液疾患)
  • An Open-labeled, Multicenter Phase II Study of Tamibarotene in Patients with Steroid-refractory Chronic Graft-versus-Host Disease

関連リンク

日本レチノイド研究会のホームページです。レチノイドの核内受容体および関連する様々なホルモン受容体を分子標的とした創薬研究が活発に行われ、抗悪性腫瘍薬、抗高脂血症薬、抗糖尿病薬が開発されています。
The retinoids are a class of chemical compounds that are related chemically to vitamin A. Retinoids are used in medicine, primarily due to the way they regulate epithelial cell growth. Retinoids have many important and diverse ...

関連画像


押しても画像が表示されない場合はサーバが混雑しています。2週間ほどあけて、再度押下してください。


★リンクテーブル★
リンク元レチノイド
拡張検索retinoid X receptor」「retinoid X receptor beta」「retinoid X receptor gamma
関連記事retinoids

レチノイド」

  [★]

retinoid
チガソン
ビタミンA合成レチノイド



retinoid X receptor」

  [★]

RXR
RXR
RXR


retinoid X receptor beta」

  [★]

レチノイドX受容体β


retinoid X receptor gamma」

  [★]

レチノイドX受容体γ


retinoids」

  [★]

See also Retinol





★コメント★

[メモ入力エリア]
※コメント5000文字まで
ニックネーム:
コメント:




表示
個人用ツール


  meddic.jp

リンク
連絡