rejection reactions

出典: meddic

拒絶反応, RR

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  • Inducible costimulator (ICOS) up-regulation on activated T cells in chronic graft-versus-host disease after dog leukocyte antigen-nonidentical hematopoietic cell transplantation: a potential therapeutic target.
  • Sato M, Storb R, Loretz C, Stone D, Mielcarek M, Sale GE, Rezvani AR, Graves SS.Source1 Transplantation Biology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA. 2 Division of Oncology, Department of Medicine, University of Washington School of Medicine, Seattle, WA. 3 Department of Pathology, University of Washington School of Medicine, Seattle, WA. 4 Address correspondence to: Dr. Scott S. Graves, Clinical Research Division, Fred Hutchinson Cancer Research Center, P.O. Box 19024, D1-100 1100 Fairview Avenue North, Seattle, WA 98109.
  • Transplantation.Transplantation.2013 Jul 15;96(1):34-41. doi: 10.1097/TP.0b013e318295c025.
  • BACKGROUND: Inducible costimulator (ICOS), a member of the CD28 family of costimulatory molecules, is induced on CD4 and CD8 T cells after their activation. ICOS functions as an essential immune regulator and ICOS blockade is a potential approach to immune modulation in allogeneic transplantation. H
  • PMID 23694952
  • Concise Review: Immunological Properties of Ocular Surface and Importance of Limbal Stem Cells for Transplantation.
  • Shaharuddin B, Ahmad S, Meeson A, Ali S.SourceInstitute of Genetic Medicine and.
  • Stem cells translational medicine.Stem Cells Transl Med.2013 Jul 1. [Epub ahead of print]
  • Cornea transplantation has been considered to be different from other solid organ transplantation because of the assumed immune-privileged state of the anterior chamber of the eye. Three major lines of thought regarding the molecular mechanisms of immune privilege in the eye are as follows: (a) anat
  • PMID 23817133
  • Treatment of Graft-versus-Host Disease with Naturally Occurring T Regulatory Cells.
  • Trzonkowski P, Dukat-Mazurek A, Bieniaszewska M, Marek-Trzonkowska N, Dobyszuk A, Juścińska J, Dutka M, Myśliwska J, Hellmann A.SourceDepartment of Clinical Immunology and Transplantology, Medical University of Gdańsk, Ul. Dębinki 1, 80-211, Gdańsk, Poland,
  • BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy.BioDrugs.2013 Jun 28. [Epub ahead of print]
  • A significant body of evidence suggests that treatment with naturally occurring CD4+CD25+ T regulatory cells (Tregs) is an appropriate therapy for graft-versus-host disease (GvHD). GvHD is a major complication of bone marrow transplantation in which the transplanted immune system recognizes recipien
  • PMID 23813436


  • 薬学的介入記録票解析による病棟薬剤師業務の効果検証
  • 高分子を利用した細胞の表面修飾と糖尿病治療への応用
  • Downregulating immunogenicity of Schwann cells via inhibiting a potential target of class II transactivator (CIITA) gene







rejectionallograft rejection, graft rejection, rejection reaction RR


  反応時期 原因 治療
超急性拒絶反応 24時間以内 体液性 レシピエント抗HLA抗体 移植臓器の摘出 免疫抑制薬無効
急性拒絶反応 1週間後~3ヶ月後 細胞性 レシピエント抗原提示細胞によるドナー抗原提示?   免疫抑制薬有効
慢性拒絶反応 3ヶ月後~ 体液性   再移植 免疫抑制薬無効






WordNet   license wordnet

「(mechanics) the equal and opposite force that is produced when any force is applied to a body; "every action has an equal and opposite reaction"」

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「a response that reveals a person''s feelings or attitude; "he was pleased by the audience''s reaction to his performance"; "John feared his mother''s reaction when she saw the broken lamp"」

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「a bodily process occurring due to the effect of some antecedent stimulus or agent; "a bad reaction to the medicine"; "his responses have slowed with age"」

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「doing something in opposition to another way of doing it that you don''t like; "his style of painting was a reaction against cubism"」

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「an idea evoked by some experience; "his reaction to the news was to start planning what to do"」

WordNet   license wordnet

「extreme conservatism in political or social matters; "the forces of reaction carried the election"」

PrepTutorEJDIC   license prepejdic

「{名}(…に対する)『反応』《+『to』+『名』》 / 〈U〉(…に対する)(政治的・社会的な)『反動』,逆コース《+『against』+『名』》 / 〈U〉〈C〉化学反応,化学変化 / 〈U〉〈C〉(物理学で)反作用」



  • n.

WordNet   license wordnet

「(medicine) an immunological response that refuses to accept substances or organisms that are recognized as foreign; "rejection of the transplanted liver"」

WordNet   license wordnet

「the state of being rejected」

WordNet   license wordnet

「the act of rejecting something; "his proposals were met with rejection"」

WordNet   license wordnet

「the speech act of rejecting」

PrepTutorEJDIC   license prepejdic

「〈U〉〈C〉断ること,拒絶;却下 / 〈C〉廃棄物」