recombination-activating gene

出典: meddic

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/02/23 13:46:31」(JST)

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  • Genetics of Cutaneous T Cell Lymphoma: From Bench to Bedside.
  • Damsky WE1, Choi J2.
  • Current treatment options in oncology.Curr Treat Options Oncol.2016 Jul;17(7):33. doi: 10.1007/s11864-016-0410-8.
  • OPINION STATEMENT: Cutaneous T cell lymphomas (CTCLs) are non-Hodgkin lymphomas of skin homing T cells. Although early-stage disease may be limited to the skin, tumor cells in later stage disease can populate the blood, the lymph nodes, and the visceral organs. Unfortunately, there are few molecular
  • PMID 27262707
  • Mechanisms of human lymphoid chromosomal translocations.
  • Lieber MR1.
  • Nature reviews. Cancer.Nat Rev Cancer.2016 May 25;16(6):387-98. doi: 10.1038/nrc.2016.40.
  • Analysis of chromosomal translocation sequence locations in human lymphomas has provided valuable clues about the mechanism of the translocations and when they occur. Biochemical analyses on the mechanisms of DNA breakage and rejoining permit formulation of detailed models of the human chromosomal t
  • PMID 27220482


  • RAG-dependent recombination at cryptic RSSs within TEL–AML1 t(12;21)(p13;q22) chromosomal translocation region
  • Numata Masashi,Saito Shoko,Nagata Kyosuke,沼田 和志,齋藤 祥子,永田 恭介
  • Biochemical and biophysical research communications 402(4), 718-724, 2010-11-26
  • … The recombination activating gene (RAG) is a lymphoid-specific endonuclease involved in the V(D)J recombination. … It has long been proposed that mis-targeting of RAG proteins is one of the factors contributing to lymphoid chromosomal translocation bearing authentic recombination signal sequences (RSSs) in immunoglobulin (Ig) and T cell receptor (TCR) gene loci or cryptic RSSs (cRSSs). …
  • NAID 120002710217


RAG1 recombination activating 1 Also known as: RAG-1; RNF74 See all available tests in GTR for this gene Go to complete Gene record for RAG1 Go to Variation Viewer for RAG1 variants Summary The protein encoded by this gene ...
RAG2 recombination activating 2 Print All Open All Close All The information on this page was automatically extracted from online scientific databases ...





  [★] recombination-activating gene


  [★] 遺伝子

WordNet   license wordnet

「(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors"」
cistron, factor

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  • n.

WordNet   license wordnet

「(genetics) a combining of genes or characters different from what they were in the parents」

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「(physics) a combining of charges or transfer of electrons in a gas that results in the neutralization of ions; important for ions arising from the passage of high-energy particles」



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「informal term for information; "give me the gen on your new line of computers"」



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「causing motion or action or change」