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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/08/25 21:10:32」(JST)
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Quinagolide
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Systematic (IUPAC) name |
N,N-diethyl-N'-[(3S,4aS,10aR)-6-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-3-yl]sulfamide
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Clinical data |
AHFS/Drugs.com |
International Drug Names |
Legal status |
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Routes of
administration |
Oral |
Identifiers |
CAS Registry Number |
87056-78-8 N |
ATC code |
G02CB04 |
PubChem |
CID: 55645 |
ChemSpider |
2343034 Y |
UNII |
80Q9QWN15M Y |
KEGG |
D07217 Y |
ChEMBL |
CHEMBL290962 Y |
Chemical data |
Formula |
C20H33N3O3S |
Molecular mass |
395.56 g/mol |
InChI
-
InChI=1S/C20H33N3O3S/c1-4-10-22-14-17(21-27(25,26)23(5-2)6-3)11-16-12-18-15(13-19(16)22)8-7-9-20(18)24/h7-9,16-17,19,21,24H,4-6,10-14H2,1-3H3/t16-,17+,19-/m1/s1 Y
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Key:GDFGTRDCCWFXTG-ZIFCJYIRSA-N Y
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N (what is this?) (verify) |
Quinagolide (Norprolac) is a selective, D2 receptor agonist that is used for the treatment of elevated levels of prolactin.[1]
See also
References
- ^ Antonella Di Sarno, Maria Luisa Landi, Paolo Marzullo, Carolina Di Somma, Rosario Pivonello, Gaetana Cerbone, Gaetano Lombardi, Annamaria Colao (July 2000). "The effect of quinagolide and cabergoline, two selective dopamine receptor type 2 agonists, in the treatment of prolactinomas". Clinical Endocrinology 53 (1): 53–60. doi:10.1046/j.1365-2265.2000.01016.x. PMID 10931080.
Tocolytics/labor repressants (G02CA)
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β2-agonists |
- Ritodrine
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Oxytocin antagonist |
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NSAID |
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Calcium channel blocker |
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Myosin inhibitor |
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Index of obstetrics
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Description |
- Pregnancy
- Development
- Anatomy
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Disease |
- Pregnancy and childbirth
- Placenta and neonate
- Infections
- Symptoms and signs
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Treatment |
- Procedures
- Drugs
- oxytocins
- labor repressants
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Sexual dysfunction pharmacotherapies
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Dopamine agonists |
- Apomorphine
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- Cabergoline
- Lisuride
- Pergolide
- Piribedil
- Pramipexole
- Quinagolide
- Ropinirole
- Rotigotine
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Melanocortin agonists |
- Bremelanotide
- Melanotan II
- PL-6983
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PDE5 inhibitors |
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Others |
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- See also: Drugs for erectile dysfunction and premature ejaculation
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Dopaminergics
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Receptor ligands
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DR |
Agonists |
- Adamantanes
- Amantadine
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- Aminotetralins
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- Ergolines
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- Dihydrexidine derivatives
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- A-86929
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- Ciladopa
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- Others
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- PD-128,907
- PD-168,077
- PF-219,061
- Piribedil
- Pramipexole
- Propylnorapomorphine
- Pukateine
- Quinagolide
- Quinelorane
- Quinpirole
- RDS-127
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- SKF-89,145
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- WAY-100,635
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Antagonists |
- Typical antipsychotics
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- Sulpiride
- Sultopride
- Thioridazine
- Thiothixene
- Trifluoperazine
- Triflupromazine
- Trifluperidol
- Zuclopenthixol
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- Atypical antipsychotics
- Amisulpride
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- Antiemetics
- AS-8112
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- Others
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- UH-232
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Reuptake modulators
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DAT |
Inhibitors |
- Piperazines
- DBL-583
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- GBR-12935
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- Pyrrolidines
- Diphenylprolinol
- MDPV
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- Tropanes
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- Others
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Enhancers |
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Modulators |
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- Antagonist-like
- SoRI-20041
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VMATs |
- Inhibitors
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- Bietaserpine
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- GBR-12935
- Ibogaine
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- Rose bengal
- Tetrabenazine
- Vanoxerine (GBR-12909)
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Releasing agents
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- Morpholines
- Fenbutrazate
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- Oxazolines
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- Phenethylamines (also amphetamines, cathinones, etc)
- 2-OH-PEA
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- Piperazines
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- BZP
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- Others
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Enzyme inhibitors
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PAH |
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TH |
- 3-Iodotyrosine
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- Bulbocapnine
- Metirosine
- Oudenone
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AAAD |
- Benserazide
- Carbidopa
- DFMD
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- Methyldopa
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MAO |
- Nonselective
- Benmoxin
- Caroxazone
- Echinopsidine
- Furazolidone
- Hydralazine
- Indantadol
- Iproclozide
- Iproniazid
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- Safrazine
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- MAO-A selective
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- Toloxatone
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- MAO-B selective
- D-Deprenyl
- Ethanol
- Ladostigil
- Lazabemide
- Milacemide
- Nicotine
- Pargyline‡
- Rasagiline
- Safinamide
- Selegiline (L-deprenyl)
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COMT |
- Entacapone
- Nitecapone
- Tolcapone
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DBH |
- Disulfiram
- Dopastin
- Fusaric acid
- Nepicastat
- Tropolone
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Others
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Precursors |
- L-Phenylalanine → L-Tyrosine → L-DOPA (levodopa)
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Cofactors |
- Ferrous iron (Fe2+)
- Tetrahydrobiopterin
- Vitamin B3 (Niacin
- Nicotinamide → NADPH)
- Vitamin B6 (Pyridoxine
- Pyridoxamine
- Pyridoxal → Pyridoxal phosphate)
- Vitamin B9 (Folic acid → Tetrahydrofolic acid)
- Vitamin C (Ascorbic acid)
- Zinc (Zn2+)
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Neurotoxins |
- Amphetamine
- Methamphetamine
- MPP+
- MPTP
- Norsalsolinol
- Oxidopamine (6-OHDA)
- Rotenone
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Others |
- Activity enhancers
- BPAP
- PPAP
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- Levodopa prodrugs
- XP21279
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- See also:
- Adrenergics
- Melatonergics
- Serotonergics
- List of dopaminergic drugs
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UpToDate Contents
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English Journal
- Do dopamine agonists prevent or reduce the severity of ovarian hyperstimulation syndrome in women undergoing assisted reproduction? A systematic review and meta-analysis.
- Baumgarten M, Polanski L, Campbell B, Raine-Fenning N.SourceUniversity of Nottingham - NURTURE, Queen's Medical Centre , Nottingham , UK.
- Human fertility (Cambridge, England).Hum Fertil (Camb).2013 Sep;16(3):168-74. doi: 10.3109/14647273.2013.833348.
- Controlled ovarian stimulation is an integral part of assisted reproduction treatment. This can result in ovarian hyperstimulation syndrome (OHSS), which is associated with significant morbidity and potentially mortality. Recent approaches to ovarian stimulation have led to a reduction in the preval
- PMID 24047196
- Pharmacoeconomic aspects of the treatment of pituitary gland tumours.
- Sowiński J, Sawicka N, Piątek K, Zybek A, Ruchała M.SourceDepartment of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poland.
- Contemporary oncology (Poznań, Poland).Contemp Oncol (Pozn).2013;17(2):137-43. doi: 10.5114/wo.2013.34616. Epub 2013 Apr 29.
- Nowadays physicians are under economic pressure; therefore therapeutic decisions based on safety, efficacy, and the effectiveness of the medication also require economic analysis. The aim of this review is to discuss data concerning the cost-effectiveness of drug therapy in patients with hormonally
- PMID 23788980
- Effect of prolactin-release inhibition on milk production and mammary gland involution at drying-off in cows.
- Ollier S, Zhao X, Lacasse P.SourceDairy and Swine Research and Development Centre, Agriculture and Agri-Food Canada, Sherbrooke, Quebec, Canada J1M 0C8.
- Journal of dairy science.J Dairy Sci.2013 Jan;96(1):335-43. doi: 10.3168/jds.2012-5955. Epub 2012 Nov 17.
- The end of each lactation is a challenging period for high-yielding cows as they are often dried off while still producing significant quantities of milk and, consequently, are highly susceptible to new intramammary infections. Once involution is complete, the mammary gland becomes much more resista
- PMID 23164222
Related Links
- Ferring社 Novartis社からプロラクチン阻害剤・NORPROLAC(quinagolide)を獲得 この記事にコメントする ‥> [無料会員登録でこの記事の第一段落が閲覧可能になります] ‥> [この記事全文を読むには有料会員登録が必要です] ‥> [有料会員 ...
- ^Antonella Di Sarno, Maria Luisa Landi, Paolo Marzullo, Carolina Di Somma, Rosario Pivonello, Gaetana Cerbone, Gaetano Lombardi, Annamaria Colao (July 2000). "The effect of quinagolide and cabergoline, two selective dopamine ...
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