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- 1. 分子遺伝学の原理 principles of molecular genetics
- 2. サラセミア症候群の分子病理 molecular pathology of the thalassemic syndromes
- 3. 遺伝性疾患の基本原則 basic principles of genetic disease
- 4. 消失性白質疾患（Vanishing white matter disease） vanishing white matter disease
- 5. ミトコンドリアの構造、機能、および遺伝学 mitochondrial structure function and genetics
- Transcriptional pathways associated with the slow growth phenotype of transformed Anaplasma marginale.
- Pierlé SA, Hammac GK, Palmer GH, Brayton KA.AbstractBACKGROUND: The ability to genetically manipulate bacteria has been fundamentally important for both basic biological discovery and translational research to develop new vaccines and antibiotics. Experimental alteration of the genetic content of prokaryotic pathogens has revealed both expected functional relationships and unexpected phenotypic consequences. Slow growth phenotypes have been reported for multiple transformed bacterial species, including extracellular and intracellular pathogens. Understanding the genes and pathways responsible for the slow growth phenotype provides the opportunity to develop attenuated vaccines as well as bacteriostatic antibiotics. Transformed Anaplasma marginale, a rickettsial pathogen, exhibits slow growth in vitro and in vivo as compared to the parent wild type strain, providing the opportunity to identify the underlying genes and pathways associated with this phenotype.
- BMC genomics.BMC Genomics.2013 Apr 22;14(1):272. [Epub ahead of print]
- BACKGROUND: The ability to genetically manipulate bacteria has been fundamentally important for both basic biological discovery and translational research to develop new vaccines and antibiotics. Experimental alteration of the genetic content of prokaryotic pathogens has revealed both expected funct
- PMID 23607288
- Selenocysteine Biosynthesis and Insertion Machinery in Naegleria gruberi.
- da Silva MT, Caldas VE, Costa FC, Silvestre DA, Thiemann OH.SourceLaboratory of Protein Crystallography and Structural Biology, IFSC-USP, Av. Trabalhador SãoCarlense 400, P.O. Box: 369, CEP 13560-970, São Carlos/SP, Brasil.
- Molecular and biochemical parasitology.Mol Biochem Parasitol.2013 Apr 18. pii: S0166-6851(13)00038-8. doi: 10.1016/j.molbiopara.2013.04.002. [Epub ahead of print]
- Selenium (Se) is an essential trace element primarily found in selenoproteins as the 21st amino acid (Selenocysteine, Sec, or U). Selenoproteins play an important role in growth and proliferation and are typically involved in cellular redox balance. Selenocysteine is encoded by an in-frame UGA codon
- PMID 23603359
- Involvement of Elongation Factor-1α in Cytokinesis without Actomyosin Contractile Ring in the Primitive Red Alga Cyanidioschyzon merolae
- Imoto Yuuta,Nishida Keiji,Yagisawa Fumi,Yoshida Yamato,Ohnuma Mio,Yoshida Masaki,Fujiwara Takayuki,Kuroiwa Haruko,Kawano Shigeyuki,Kuroiwa Tsuneyoshi
- CYTOLOGIA 76(4), 431-437, 2011
- … Although eEF-1α is a ubiquitous protein translation factor and is highly conserved in eukaryotes, archaea, and prokaryotes, the archaebacterial EF-1α and the prokaryotic EF-1α ortholog EF-Tu do not function in cytokinesis, suggesting that the association between the contractile ring and EF-1α appeared at about the same time as the establishment of eukaryotic cells. …
- NAID 130004448150
- Shine-Dalgarno sequence enhances the efficiency of lacZ repression by artificial anti-lac antisense RNAs in Escherichia coli(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
- Stefan Alessandra,Schwarz Flavio,Bressanin Daniela [他],Hochkoeppler Alejandro
- Journal of bioscience and bioengineering 110(5), 523-528, 2010-11
- … Because the concentration of the lac mRNA was always high in cells that expressed Zcal1, we hypothesize that this antisense acts by inhibiting messenger translation. … Our observations will contribute to the understanding of the main determinants of silencing as exerted by asRNAs as well as provide useful support for the design of robust and efficient prokaryotic gene silencers. …
- NAID 110007988800
- A "difference between" reference site ... Translation or protein synthesis is a process during which the genetic information is translated, following the dictations of the genetic code, into the sequence of amino acids in a polypeptide ...
- Initiation  Initiation of translation in prokaryotes involves the assembly of the components of the translation system, which are: the two ribosomal subunits (50S and 30S subunits); the mature mRNA to be translated; the tRNA ...