WordNet
- of first rank or importance or value; direct and immediate rather than secondary; "primary goals"; "a primary effect"; "primary sources"; "a primary interest"
- a preliminary election where delegates or nominees are chosen (同)primary_election
- one of the main flight feathers projecting along the outer edge of a birds wing (同)primary feather, primary quill
- (astronomy) a celestial body (especially a star) relative to other objects in orbit around it
- not derived from or reducible to something else; basic; "a primary instinct"
- flow under pressure
- an unrestrained expression of emotion (同)gush, outburst, blowup, ebullition
- a neoplasm of lymph tissue that is usually malignant; one of the four major types of cancer
PrepTutorEJDIC
- 『第一の』,『主要な』 / 『初期の』,『初等の』,初級の / 『根本的な』,基本的な,本来の,直接的な / 《名詞の前にのみ用いて》(回路・コイル・巻き・電流などが)一次の / 原色(三原色の一つ) / 《米》=primary election
- 〈U〉流出,噴出;〈C〉流出物(量) / 〈C〉(感情・言葉などの,通例過剰な)吐露,ほとばしり
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/04/16 18:02:30」(JST)
[Wiki en表示]
| Primary effusion lymphoma |
| Classification and external resources |
| Specialty |
Hematology and oncology |
| ICD-O |
M9678/3 |
| DiseasesDB |
33904 |
| MeSH |
D054685 |
Primary effusion lymphoma (PEL) is a B-cell lymphoma, presenting with a malignant effusion without a tumor mass.[1][2]:879-881
Contents
- 1 Causes
- 2 Presentation
- 3 History
- 4 Prognosis
- 5 See also
- 6 References
Causes
PEL most commonly arises in patients with underlying immunodeficiency, such as AIDS.[3][4] PEL is caused by Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8).[5][6] In most cases, the lymphoma cells are also infected with Epstein Barr virus (EBV).[7]
The condition can exist in the absence of HHV-8 and HIV, though this is rare.[8]
Presentation
PEL is unusual in that the majority of cases arise in body cavities, such as the pleural space or the pericardium; another name for PEL is "body cavity lymphoma".
The immunophenotype : CD45+ (95%), CD20-, CD79a-, PAX5-, CD30+, CD38+, CD138+ and EMA+.[2]:879-881 Staining the nucleus for HHV-8 LANA may be helpful.[2]:879-881
History
It was recognized as a unique type of lymphoma only after the discovery of KSHV in 1994.
Prognosis
It is generally resistant to cancer chemotherapy drugs that are active against other lymphomas, and carries a poor prognosis.[9]
Sirolimus has been proposed as a treatment option.[10]
See also
- List of hematologic conditions
References
- ^ Swerdlow, Steven H.; International Agency for Research on Cancer; World Health Organization (2008). WHO classification of tumours of haematopoietic and lymphoid tissues. World Health Organization classification of tumours 2 (4th ed.). International Agency for Research on Cancer. ISBN 9789283224310.
- ^ a b c Jaffe, ES; Harris NL, Vardiman JW, Campo E, Arber, DA. (2011). Hematopathology (1st ed.). Elsevier Saunders. ISBN 9780721600406.
- ^ Boshoff C, Weiss R (May 2002). "AIDS-related malignancies". Nat. Rev. Cancer 2 (5): 373–82. doi:10.1038/nrc797. PMID 12044013.
- ^ Yarchoan R, Tosato G, Little RF (August 2005). "Therapy insight: AIDS-related malignancies--the influence of antiviral therapy on pathogenesis and management". Nat Clin Pract Oncol 2 (8): 406–15; quiz 423. doi:10.1038/ncponc0253. PMID 16130937.
- ^ Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM (May 1995). "Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas". N. Engl. J. Med. 332 (18): 1186–91. doi:10.1056/NEJM199505043321802. PMID 7700311.
- ^ Staudt MR, Kanan Y, Jeong JH, Papin JF, Hines-Boykin R, Dittmer DP (July 2004). "The tumor microenvironment controls primary effusion lymphoma growth in vivo". Cancer Res. 64 (14): 4790–9. doi:10.1158/0008-5472.CAN-03-3835. PMID 15256448.
- ^ Fan W, Bubman D, Chadburn A, Harrington WJ, Cesarman E, Knowles DM (January 2005). "Distinct subsets of primary effusion lymphoma can be identified based on their cellular gene expression profile and viral association". J. Virol. 79 (2): 1244–51. doi:10.1128/JVI.79.2.1244-1251.2005. PMC 538532. PMID 15613351.
- ^ Youngster I, Vaisben E, Cohen H, Nassar F (January 2006). "An unusual cause of pleural effusion". Age Ageing 35 (1): 94–6. doi:10.1093/ageing/afj009. PMID 16364944.
- ^ Chen YB, Rahemtullah A, Hochberg E (May 2007). "Primary effusion lymphoma". Oncologist 12 (5): 569–76. doi:10.1634/theoncologist.12-5-569. PMID 17522245.
- ^ Sin SH, Roy D, Wang L et al. (March 2007). "Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling". Blood 109 (5): 2165–73. doi:10.1182/blood-2006-06-028092. PMC 1801055. PMID 17082322.
|
Hematological malignancy/leukemia histology (ICD-O 9590–9989, C81–C96, 200–208)
Lymphoid/Lymphoproliferative, Lymphomas/Lymphoid leukemias (9590–9739, 9800–9839)
|
|
B cell
(lymphoma,
leukemia)
(most CD19
|
By development/
marker |
| TdT+ |
- ALL (Precursor B acute lymphoblastic leukemia/lymphoma)
|
|
| CD5+ |
- mantle zone (Mantle cell)
|
|
| CD22+ |
- Prolymphocytic
- CD11c+ (Hairy cell leukemia)
|
|
| CD79a+ |
- germinal center/follicular B cell (Follicular
- Burkitt's
- GCB DLBCL
- Primary cutaneous follicular lymphoma)
- marginal zone/marginal-zone B cell (Splenic marginal zone
- MALT
- Nodal marginal zone
- Primary cutaneous marginal zone lymphoma)
|
|
| RS (CD15+, CD30+) |
- Classic Hodgkin's lymphoma (Nodular sclerosis)
- CD20+ (Nodular lymphocyte predominant Hodgkin's lymphoma)
|
|
PCDs/PP
(CD38+/CD138+) |
- see immunoproliferative immunoglobulin disorders
|
|
|
| By infection |
- KSHV (Primary effusion)
- EBV (Lymphomatoid granulomatosis
- Post-transplant lymphoproliferative disorder)
- HIV (AIDS-related lymphoma)
- Helicobacter pylori (MALT lymphoma)
|
|
| Cutaneous |
- Diffuse large B-cell lymphoma
- Intravascular large B-cell lymphoma
- Primary cutaneous marginal zone lymphoma
- Primary cutaneous immunocytoma
- Plasmacytoma
- Plasmacytosis
- Primary cutaneous follicular lymphoma
|
|
|
| T/NK |
T cell
(lymphoma,
leukemia)
(most CD3
|
By development/
marker |
- TdT+: ALL (Precursor T acute lymphoblastic leukemia/lymphoma)
- prolymphocyte (Prolymphocytic)
- CD30+ (Anaplastic large-cell lymphoma
- Lymphomatoid papulosis type A)
|
|
| Cutaneous |
| MF+variants |
- indolent: Mycosis fungoides
- Pagetoid reticulosis
- Granulomatous slack skin
aggressive: Sézary disease
- Adult T-cell leukemia/lymphoma
|
|
| Non-MF |
- CD30-: Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma
- Pleomorphic T-cell lymphoma
- Lymphomatoid papulosis type B
- CD30+: CD30+ cutaneous T-cell lymphoma
- Secondary cutaneous CD30+ large cell lymphoma
- Lymphomatoid papulosis type A
|
|
|
| Other peripheral |
- Hepatosplenic
- Angioimmunoblastic
- Enteropathy-associated T-cell lymphoma
- Peripheral T-cell lymphoma-Not-Otherwise-Specified (Lennert lymphoma)
- Subcutaneous T-cell lymphoma
|
|
| By infection |
- HTLV-1 (Adult T-cell leukemia/lymphoma)
|
|
|
NK cell/
(most CD56) |
- Aggressive NK-cell leukemia
- Blastic NK cell lymphoma
|
|
| T or NK |
- EBV (Extranodal NK-T-cell lymphoma/Angiocentric lymphoma)
- Large granular lymphocytic leukemia
|
|
|
| Lymphoid+myeloid |
- Acute biphenotypic leukaemia
|
|
| Lymphocytosis |
- Lymphoproliferative disorders (X-linked lymphoproliferative disease
- Autoimmune lymphoproliferative syndrome)
- Leukemoid reaction
- Diffuse infiltrative lymphocytosis syndrome
|
|
|
| Cutaneous lymphoid hyperplasia |
- Cutaneous lymphoid hyperplasia
- with bandlike and perivascular patterns
- with nodular pattern
- Jessner lymphocytic infiltrate of the skin
|
|
|
Index of the immune system
|
|
| Description |
- Physiology
- cells
- autoantigens
- autoantibodies
- complement
- surface antigens
- IG receptors
|
|
| Disease |
- Allergies
- Immunodeficiency
- Immunoproliferative immunoglobulin disorders
- Hypersensitivity and autoimmune disorders
- Neoplasms and cancer
|
|
| Treatment |
- Procedures
- Drugs
- antihistamines
- immunostimulants
- immunosuppressants
- monoclonal antibodies
|
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Anticancer drug-loaded quantum dots engineered polymeric nanoparticles: Diagnosis/therapy combined approach.
- Belletti D1, Riva G2, Luppi M2, Tosi G1, Forni F1, Vandelli MA1, Ruozi B3, Pederzoli F1.
- European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.Eur J Pharm Sci.2017 Sep 30;107:230-239. doi: 10.1016/j.ejps.2017.07.020. Epub 2017 Jul 18.
- PMID 28728978
- HIV-associated Kaposi sarcoma and related diseases.
- Gonçalves PH1, Uldrick TS, Yarchoan R.
- AIDS (London, England).AIDS.2017 Sep 10;31(14):1903-1916. doi: 10.1097/QAD.0000000000001567.
- PMID 28609402
- HHV8 genotype study in an HIV+ patient with concurrent Kaposi sarcoma and extracavitary primary effusion lymphoma.
- Fung KH1, Raghupathy R2, Chan PD3, Lui G4, Lam CY3, Cheung M3, Chan AW5, Lee N4, Lee SS3.
- Journal of clinical pathology.J Clin Pathol.2017 Sep;70(9):814-816. doi: 10.1136/jclinpath-2017-204485. Epub 2017 Jul 13.
- PMID 28705937
Japanese Journal
- 心嚢水貯留と房室ブロックを伴った心臓および乳腺のびまん性大細胞型B細胞リンパ腫
- 富川 武樹,多林 孝之,得平 道英 [他],渡部 玲子,佐川 森彦,根本 朋恵,木村 勇太,高橋 康之,森 茂久,東 守洋,田丸 淳一,木崎 昌弘
- 臨床血液 56(1), 9-15, 2015
- 心臓原発悪性リンパ腫は稀な疾患で，一般に予後不良である。症状の顕在化が遅く，診断が遅れることが多い。今回，我々は心嚢水貯留と房室ブロックにて発症したびまん性大細胞型B細胞リンパ腫(DLBCL)の1症例を経験した。患者は35歳女性。呼吸苦と胸痛，左乳腺の硬い腫瘤を主訴に受診した。心電図検査ではI度房室ブロックを示し，心臓超音波検査では右心房と心房中隔に腫瘤影を認め，多量の心嚢水貯留を認めた。左乳腺腫 …
- NAID 130004920697
- 症例報告 リツキシマブ併用ソブゾキサンおよびエトポシドの経口少量療法が奏効した高齢者ヒトヘルペスウイルス8陰性Primary effusion lymphoma-like lymphoma
Related Links
- Figure 1. Morphology and immunophenotype of primary effusion lymphoma (PEL). Both pleural fluid (A) (Papanicolaou, 400×) and pleural biopsy (B) (hematoxylin and eosin, 400×) specimens of a case of PEL show pleomorphic large ...
- 1. Arch Pathol Lab Med. 2013 Aug;137(8):1152-4. doi: 10.5858/arpa.2012-0294-RS. Primary effusion lymphoma. Patel S(1), Xiao P. Author information: (1)Department of Pathology and Laboratory Medicine, The ...
Related Pictures
★リンクテーブル★
[★]
- 英
- primary effusion lymphoma PEL
- 同
- 原発性浸出性リンパ腫？？？
[★]
- 英
- primary effusion lymphoma
[★]
- 英
- primary effusion lymphoma
[★]
- 一次の、第一次の、主要な、(化学)第一級の、一級の、初生の、(病名)原発性の、原発の、プライマリーの
- 関
- cardinal、chief、first-order、foremost、main、mainly、major、master、primarily、principal、principally
[★]
- 関
- decoction、effuse、exudate、exudation、exude、imbibition、leach、leachate、leaching、oozing、percolate、percolation