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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/02/21 16:21:36」(JST)

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  • A ubiquitin-binding CUE domain in presenilin-1 enables interaction with K63-linked polyubiquitin chains.
  • Duggan SP1, Yan R1, McCarthy JV2.
  • FEBS letters.FEBS Lett.2015 Apr 13;589(9):1001-8. doi: 10.1016/j.febslet.2015.03.008. Epub 2015 Mar 18.
  • The presenilins (PS1 and PS2) are the catalytic component of the γ-secretase intramembrane protease complex, involved in the regulated intramembrane proteolysis of numerous type I transmembrane proteins, including amyloid precursor protein (APP) and Notch. Herein, we describe the identification and
  • PMID 25796185
  • Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex.
  • Marinangeli C1, Tasiaux B1, Opsomer R1, Hage S2, Sodero AO1, Dewachter I1, Octave JN1, Smith SO3, Constantinescu SN4, Kienlen-Campard P5.
  • The Journal of biological chemistry.J Biol Chem.2015 Mar 13;290(11):7169-84. doi: 10.1074/jbc.M114.601286. Epub 2015 Jan 22.
  • Understanding the molecular mechanisms controlling the physiological and pathological activity of γ-secretase represents a challenging task in Alzheimer disease research. The assembly and proteolytic activity of this enzyme require the correct interaction of the 19 transmembrane domains (TMDs) pres
  • PMID 25614624
  • Presenilin-like GxGD membrane proteases have dual roles as proteolytic enzymes and ion channels.
  • Kuo IY1, Hu J1, Ha Y1, Ehrlich BE2.
  • The Journal of biological chemistry.J Biol Chem.2015 Mar 6;290(10):6419-27. doi: 10.1074/jbc.M114.629584. Epub 2015 Jan 21.
  • The GxGD proteases function to cleave protein substrates within the membrane. As these proteases contain multiple transmembrane domains typical of ion channels, we examined if GxGD proteases also function as ion channels. We tested the putative dual function by examining two archeobacterial GxGD pro
  • PMID 25609250


  • Modeling familial Alzheimer's disease with induced pluripotent stem cells
  • 家族性アルツハイマー病の病因遺伝子 プレセニリン (アルツハイマー病--基礎研究から予防・治療の新しいパラダイム) -- (アルツハイマー病の病理・病態)
  • プレセニリン:ツメガエル分子発生学に基づく活性制御モデル